Unveiling the potential of HKUST-1: synthesis, activation, advantages and biomedical applications

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(11), С. 2670 - 2690

Опубликована: Янв. 1, 2024

HKUST-1 represents a promising biomaterial, functioning not only as drug carrier but also releasing bioactive copper ions, thereby demonstrating exceptional antitumor, antibacterial, and wound healing properties.

Язык: Английский

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Protein Coronas Derived from Mucus Act as Both Spear and Shield to Regulate Transferrin Functionalized Nanoparticle Transcellular Transport in Enterocytes

ACS Nano, Год журнала: 2024, Номер 18(10), С. 7455 - 7472

Опубликована: Фев. 28, 2024

The epithelial mucosa is a key biological barrier faced by gastrointestinal, intraoral, intranasal, ocular, and vaginal drug delivery. Ligand-modified nanoparticles demonstrate excellent ability on this process, but their efficacy diminished the formation of protein coronas (PCs) when they interact with matrices. PCs are broadly implicated in affecting fate NPs vivo vitro, yet few studies have investigated formed during interactions mucosa, especially mucus. In study, we constructed transferrin modified (Tf-NPs) as model explored mechanisms effects that had subsequent impact transcellular transport Tf-NPs. mucus-secreting cells, Tf-NPs adsorbed more proteins from mucus layers, which masked, displaced, dampened active targeting Tf-NPs, thereby weakening endocytosis efficiencies. mucus-free intracellular trafficking, enhanced transcytosis related functions. Inspired soft artificial biomimetic membranes, used mucin an "active PC" to precoat (M@Tf-NPs), limited negative impacts "passive PCs" interface improved favorable routes endocytosis. M@Tf-NPs associated endoplasmic reticulum-Golgi functions, prompting exocytosis. summary, shielded against absorption also could be employed spear break through barrier. These findings offer theoretical foundation design platform enhance efficiency oral-administered nanomedicines.

Язык: Английский

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Polymersomes as the Next Attractive Generation of Drug Delivery Systems: Definition, Synthesis and Applications

Materials, Год журнала: 2024, Номер 17(2), С. 319 - 319

Опубликована: Янв. 8, 2024

Polymersomes are artificial nanoparticles formed by the self-assembly process of amphiphilic block copolymers composed hydrophobic and hydrophilic blocks. They can encapsulate molecules in aqueous core within membrane. The composition be tuned, enabling control characteristics properties polymersomes and, thus, their application areas such as drug delivery, diagnostics, or bioimaging. preparation methods also impact preservation encapsulated drugs. Many have been described, including direct hydration, thin film electroporation, pH-switch method, solvent shift single double emulsion flash nanoprecipitation, microfluidic synthesis. Considering polymersome structure composition, there several types theranostic polymersomes, decorated with targeting ligands for selective stimuli-responsive porous multiple promising applications. Due to shortcomings related stability, efficacy, safety some therapeutics human body, delivery systems good candidates improve quality therapies against a wide range diseases, cancer. Chemotherapy immunotherapy improved using deliver drugs, protecting directing them exact site action. Moreover, this approach is targeted biologics since they represent class drugs poor stability high susceptibility vivo clearance. However, lack well-defined regulatory plan formulations has hampered follow-up clinical trials subsequent market entry.

Язык: Английский

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A mitochondria-targeted anticancer copper dithiocarbamate amplifies immunogenic cuproptosis and macrophage polarization

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(8), С. 2006 - 2014

Опубликована: Янв. 1, 2024

A mitochondrial targeting copper dithiocarbamate induces intense immunogenic cuproptosis in cancer cells and macrophage M1 polarization. This emphasizes the potential of inducers immunotherapy.

Язык: Английский

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Nanoengineered polymers and other organic materials in lung cancer treatment: Bridging the gap between research and clinical applications

European Polymer Journal, Год журнала: 2024, Номер 208, С. 112891 - 112891

Опубликована: Фев. 27, 2024

Cancer remains a major global health challenge, with increasing incidence and mortality rates projected for the coming years. Lung cancer, in particular, poses significant obstacles due to late-stage diagnosis limited treatment options. While advancements molecular diagnostics have been made, there is critical need connect dots between laboratory hospital better lung cancer treatment. Systemic therapy plays crucial role treating advanced-stage recent efforts focused on developing innovative drug delivery techniques. Nanoparticles (NPs) emerged as promising approach treatment, offering enhanced delivery, active targeting, reduced toxicity. Organic-based nanomaterials, like polymeric nanoparticles, solid lipid liposomes hold great potential this field. This review examines application of NPs highlights current therapies, explores organic nanoparticle-based approaches, discusses limitations future perspectives clinical translation.

Язык: Английский

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Triune Nanomodulator Enables Exhausted Cytotoxic T Lymphocyte Rejuvenation for Cancer Epigenetic Immunotherapy

ACS Nano, Год журнала: 2024, Номер 18(20), С. 13226 - 13240

Опубликована: Май 7, 2024

Oncogene activation and epigenome dysregulation drive tumor initiation progression, contributing to immune evasion compromising the clinical response immunotherapy. Epigenetic immunotherapy represents a promising paradigm in conquering cancer immunosuppression, whereas few relevant drug combination delivery strategies emerge clinic. This study presents well-designed triune nanomodulator, termed ROCA, which demonstrates robust capabilities epigenetic modulation microenvironment reprogramming for The nanomodulator is engineered from nanoscale framework with cascaded catalytic activity, self-assembles into nanoaggregate targeting polypeptide decoration that enables loading of immunogenic cell death (ICD)-inducing agent. releases active factors specifically triggered microenvironment, represses oncogene expression, initiates type 1 T helper (TH1) chemokine axis by reversing DNA hypermethylation. process, together ICD induction, fundamentally reprograms significantly enhances rejuvenation exhausted cytotoxic lymphocytes (CTLs, CD8+ cells), synergizes anti-PD-L1 checkpoint blockade results boosted antitumor response. Furthermore, this strategy establishes long-term memory effectively prevents orthotopic colon relapse. Therefore, holds promise as standalone agent or part therapy inhibitors preclinical models, broadening array combinatorial

Язык: Английский

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Язык: Английский

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Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives

Bioactive Materials, Год журнала: 2023, Номер 32, С. 445 - 472

Опубликована: Окт. 26, 2023

Effective tumor treatment depends on optimizing drug penetration and accumulation in tissue while minimizing systemic toxicity. Nanomedicine has emerged as a key solution that addresses the rapid clearance of free drugs, but achieving deep into solid tumors remains elusive. This review discusses various strategies to enhance penetration, including manipulation microenvironment, exploitation both external internal stimuli, pioneering nanocarrier surface engineering, development innovative tactics for active penetration. One outstanding strategy is organelle-affinitive transfer, which exploits unique properties specific cell organelles heralds potentially transformative approach transcellular transfer Rigorous models are essential evaluate efficacy these strategies. The patient-derived xenograft (PDX) model gaining traction bridge between laboratory discovery clinical application. However, journey from bench bedside nanomedicines fraught with challenges. Future efforts should prioritize deepening our understanding nanoparticle-tumor interactions, re-evaluating EPR effect, exploring novel nanoparticle transport mechanisms.

Язык: Английский

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Nanomedicine Combats Drug Resistance in Lung Cancer

Advanced Materials, Год журнала: 2023, Номер 36(3)

Опубликована: Ноя. 16, 2023

Lung cancer is the second most prevalent and leading cause of cancer-related death worldwide. Surgery, chemotherapy, molecular targeted therapy, immunotherapy, radiotherapy are currently available as treatment methods. However, drug resistance a significant factor in failure lung treatments. Novel therapeutics have been exploited to address complicated mechanisms advancement nanomedicine extremely promising terms overcoming resistance. Nanomedicine equipped with multifunctional tunable physiochemical properties alignment tumor genetic profiles can achieve precise, safe, effective while minimizing or eradicating cancer. Here, this work reviews discovered for radiotherapy, outlines novel strategies development against This focuses on engineering design, customized delivery, current challenges, clinical translation application resistant

Язык: Английский

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Different Valence States of Copper Ion Delivery against Triple-Negative Breast Cancer

ACS Nano, Год журнала: 2024, Номер unknown

Опубликована: Фев. 6, 2024

Different valence states of copper (Cu) ions are involved in complicated redox reactions vivo, which closely related to tumor proliferation and death pathways, such as cuproptosis chemodynamic therapy (CDT). Cu ion mediated Fenton-like reagents induced cell presents compelling attention for the CDT tumors. However, superiority different antitumor effect is unknown. In this study, we investigated modulating by Cu-chelated cyanine dye against triple-negative breast cancer. The cuprous (Cu+) (Cu2+) were chelated with four nitrogen atoms dipicolylethylenediamine-modified construction Cu+ Cu2+ dyes (denoted CC1 CC2, respectively). Upon 660 nm laser irradiation, or CC2 can generate reactive oxygen species, could disrupt structure, achieving rapid release initiating reaction CDT. Compared Cu2+-based reagent, exhibited a better therapeutic outcome due there being no need reduction glutathione shorter route more hydroxyl radicals. Our findings suggest precision delivery achieve highly efficient therapy.

Язык: Английский

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