Cognitive impairment in long-COVID

Ideggyógyászati Szemle, Год журнала: 2024, Номер 77(5-6), С. 151 - 159

Опубликована: Янв. 1, 2024

Background – Long Covid is a complex condition characterised by symptoms that persist for weeks and months after the infection, accompanied cognitive im­pairment negatively affects daily life. Understanding this important development of diagnostic therapeutic strategies. Purpose This article aims to provide comprehensive overview impairment in long-COVID, including its definition, symptoms, pathophysiology, risk factors, assessment tools, imaging abnormalities, potential biomarkers, management strategies, long-term outcomes, future directions research. Methods The search methodology used review aimed include wide range research on related both COVID-19 long-COVID. Systematic searches PubMed Google Scholar databases were conducted using mixture MeSH terms keywords ‘cognition’, ‘cognitive impairment’, ‘brain fog’, ‘COVID-19’ ‘long-COVID’. was restricted studies published English between 1 January 2019 11 February 2024, which presented findings neurological manifestations human participants. Results Long-COVID characterized persistent following with being prominent feature. Symptoms brain fog, difficulties concentration, memory issues, executive function deficits. Pathophysiological mechanisms involve viral persistence, immune responses, vascular damage. Risk factors age, pre-existing conditions, disease severity. Cognitive tools such as Montreal Assessment (MoCA) are essential diagnosis. Imaging studies, MRI, PET, SPECT, reveal structural functional alterations. Potential biomarkers C-reactive protein, interleukin-6, neuron-specific enolase. Management strategies encompass rehabilitation, occupational therapy, medications, lifestyle modifications. Discussion poses multifaceted challenge, significantly impacts patients’ lives. A multidisciplinary approach, rehabilitation medication when appropriate, effective management. Future should focus validating understanding outcomes. Conclusion global health concern, distressing symptom. While pharmacological interventions have potential, they require careful consideration. Continued crucial improving treatment

Язык: Английский

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A multidisciplinary approach to assessment and management of long COVID cognitive concerns

Life Sciences, Год журнала: 2024, Номер 357, С. 123068 - 123068

Опубликована: Сен. 18, 2024

Язык: Английский

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Proteomic analysis of Post-COVID Condition: Insights from plasma and pellet blood fractions

Journal of Infection and Public Health, Год журнала: 2024, Номер 17(12), С. 102571 - 102571

Опубликована: Окт. 23, 2024

Язык: Английский

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The impact of COVID-19 on pulmonary, neurological, and cardiac outcomes: evidence from a Mendelian randomization study

Frontiers in Public Health, Год журнала: 2023, Номер 11

Опубликована: Дек. 14, 2023

Background Long COVID is a clinical entity characterized by persistent health problems or development of new diseases, without an alternative diagnosis, following SARS-CoV-2 infection that affects significant proportion individuals globally. It can manifest with wide range symptoms due to dysfunction multiple organ systems including but not limited cardiovascular, hematologic, neurological, gastrointestinal, and renal organs, revealed observational studies. However, causal association between the genetic predisposition COVID-19 many post-infective abnormalities in long remain unclear. Methods Here we employed Mendelian randomization (MR), robust epidemiological approach, investigate potential associations symptoms, namely pulmonary (pneumonia airway infections bronchitis, emphysema, asthma, rhinitis), neurological (headache, depression, Parkinson’s disease), cardiac (heart failure chest pain) chronic fatigue. Using two-sample MR, leveraged data from large genome-wide study various disorder-specific datasets. Results This analysis was significantly causally linked increased risk developing pneumonia, infections, headache, heart failure. also showed strong positive correlation fatigue, frequently observed symptom patients. our findings on disease, pain were inconclusive. Conclusion Overall, these provide valuable insights into underpinnings its diverse symptoms. Understanding may aid better management treatment patients, thereby alleviating substantial burden it poses global socioeconomic systems.

Язык: Английский

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Unmasking Pandemic Echoes: An In-Depth Review of Long COVID’s Unabated Cardiovascular Consequences beyond 2020

Diagnostics, Год журнала: 2023, Номер 13(21), С. 3368 - 3368

Опубликована: Ноя. 2, 2023

At the beginning of 2020, coronavirus disease 2019 (COVID-19) emerged as a new pandemic, leading to worldwide health crisis and overwhelming healthcare systems due high numbers hospital admissions, insufficient resources, lack standardized therapeutic protocols. Multiple genetic variants severe acute respiratory syndrome 2 (SARS-CoV-2) have been detected since its first public declaration in some them being considered concern (VOCs) corresponding several pandemic waves. Nevertheless, growing number COVID-19 patients are continuously discharged from hospitals, remaining symptomatic even months after their episode infection. Long or ‘post-acute syndrome’ characterized by variability clinical manifestations ranging cardiorespiratory neurological symptoms such chest pain, exertional dyspnoea cognitive disturbance psychological disturbances, e.g., depression, anxiety sleep with crucial impact on patients’ quality life. Moreover, COVID is viewed cardiovascular risk factor capable modifying trajectory current future diseases, altering prognosis. Therefore, this review we address definitions pathophysiology, focus manifestations. Furthermore, aim mechanisms chronic cardiac injury variety sequelae observed recovered patients, addition potential role clinics medical management condition. We will further research for better understanding actual directions.

Язык: Английский

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Intravenous immunoglobulin as a potential treatment for long COVID

Expert Opinion on Biological Therapy, Год журнала: 2023, Номер 23(12), С. 1211 - 1217

Опубликована: Дек. 2, 2023

Introduction On 31 July 2023, the United States Department of Health and Human Services announced formation Office Long COVID Research Practice National Institutes (NIH) opened enrollment for therapeutic arm RECOVER initiative, a prospective, randomized study to evaluate new treatment options long coronavirus disease 2019 (long COVID).

Язык: Английский

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The Natural History of SARS-CoV-2-Incurred Disease: From Infection to Long COVID

International Journal of Translational Medicine, Год журнала: 2024, Номер 4(1), С. 72 - 86

Опубликована: Янв. 8, 2024

The coronavirus SARS-CoV-2 is the causative pathogen of COVID-19 pandemic that has been causing global upheaval since 2019. widespread administration vaccines partially deterred spread SARS-CoV-2, yet virus mutating its genome to reduce antigenicity and evade human herd immunity. It seems will co-exist with population for many decades come. While most infected individuals only experience mild moderate symptoms, some develop severe pulmonary systemic disease can result in hospitalization or even death. natural history model infection proposed which includes three sequential stages: early stage, hyper-inflammatory stage. Recently, it observed people who recovered from an acute still persistent symptoms weeks months, a condition known as long COVID. Furthermore, patients display escalated rates both macro- micro-thrombosis due endotheliopathy. Hence, we added thrombosis convalescent stages model, encompassing entire period stage characterized by symptomatic asymptomatic elevation viral titers. Some progress opacities chest X-rays computed tomography. heightened consistently elevated D-dimer levels. storms cytokines, such IL-6, IL-17, interferons, effect. In recover completely, while others suffer COVID fatigue, shortness breath, brain fog. be used elucidate treatment care.

Язык: Английский

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Characterizing health-related quality of life and identifying disease predictors among patients suspected of having long COVID: an analysis of COMET-ICE clinical trial data

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Май 9, 2024

Introduction Long COVID affects health-related quality of life (HRQoL). Here, we investigate the extent to which symptoms experienced during acute phase COVID-19 are significant predictors presence long at 12 weeks. Methods Post-hoc analysis COMET-ICE trial data, assessed sotrovimab vs. placebo for treatment mild-to-moderate among high-risk patients. Patient-reported outcome measures were completed trial, including inFLUenza Patient-Reported Outcome Plus (FLU-PRO Plus), 12-Item Short Form (SF-12) Hybrid questionnaire, and Work Productivity Activity Impairment Questionnaire: General Health (WPAI:GH). impacts (measured by FLU-PRO Plus) HRQoL SF-12 WPAI:GH) compared between (Days 1–21 29) long-COVID (at Week 12) patients with without based on data. Subgroups experiencing derived using “All,” “Returning,” “Persisting” symptomatic definitions. Long-COVID identified a multivariate logistic regression model; odds ratios (ORs) 95% CIs calculated. Results subgroups had significantly higher baseline scores most domains Total Score non-long-COVID group. WPAI:GH generally showed more impairment In univariate analyses, all (all p < 0.05), exception Sense domain. Older age increased risk (OR 1.02, CI 1.00–1.04, 0.05). Non-White less likely have Returning Persisting definitions White analysis, Nose domain (ORs 3.39–5.60, 0.01) having COPD 3.75–6.34, 0.05) predictors. Conclusion Patients who progressed symptom severity disease greater negative impact over an extended time period from initial infection through least subsequent 3 months. The COVID.

Язык: Английский

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Association of LEF1-AS1 with cardiovascular and neurological complications of COVID-19

Journal of Molecular and Cellular Cardiology Plus, Год журнала: 2024, Номер 11, С. 100280 - 100280

Опубликована: Дек. 22, 2024

A significant proportion of COVID-19 patients develop long-term complications, particularly cardiovascular and neurological issues. Even though risk factors for developing complications after have been identified, a biomarker to predict these could enable personalized healthcare potentially reduce the disease burden. Easily measurable in blood, long noncoding RNA LEF1-AS1 has recently associated with in-hospital mortality following SARS-CoV - 2 infection holds potential as severity patients. Consequently, we examined LEF1-AS1's ability COVID-19. measured blood by quantitative PCR 104 primo-infected participants from Predi-COVID cohort within 3 days post clinical PCR-confirmed diagnosis. Among them, 35 (34 %) reported at least one persistent symptom or ocular self-administered questionnaire 12 months Blood levels baseline were lower (p = 0.019) compared those who did not report symptoms. Lower symptoms an odds ratio 0.48 (95 % confidence interval 0.28-0.83) logistic regression model adjusted age, sex, comorbidity, moderate baseline. expression was positively correlated frequency naïve T cells negatively effector memory among total CD8+ cells, revealing association between T-cell differentiation SARS-CoV-2 infection. In conclusion, can help predicting 12-month patients, this finding requires validation larger cohorts.

Язык: Английский

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Long Covid-19 Syndrome: the Prevalence of Neuropsychiatric Symptoms in Patients with Olfactory Disorders

Опубликована: Дек. 29, 2023

Background: Among the frequently reported symptoms in long-term COVID-19 syndrome, we can highlight olfactory disorders depression, anxiety, and fatigue. OD affect people's physical mental health lead to neuropsychiatric symptoms. Objective: Determine prevalence of fatigue patients with induced by COVID-19; investigate this impact on quality life. Methods: The study included 30 confirmed COVID-19, persistent complaints dysfunction. was evaluated connecticut smell test. Neuropsychiatric were severity hospital anxiety depression scales. Quality life accessed using SF-36. Results: 70% had different degrees hyposmia 20% anosmia. most prevalent symptom 66.7% sample. More than half also (53,3% both). affected dimensions SF-36 emotional, vitality, role (36.6 ± 44.0, 44.3 28.7, 47.5 42.7, 49.8 24.7 respectively). There a moderate negative correlation between dimension. general health, social functioning, dimensions. Symptoms obtained function Conclusion: is high these patients, highlighting emotional aspect.

Язык: Английский

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