NAD+ metabolism and its roles in cellular processes during ageing

Nature Reviews Molecular Cell Biology, Год журнала: 2020, Номер 22(2), С. 119 - 141

Опубликована: Дек. 22, 2020

Язык: Английский

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Neuronal Cell Death

Physiological Reviews, Год журнала: 2018, Номер 98(2), С. 813 - 880

Опубликована: Фев. 28, 2018

Neuronal cell death occurs extensively during development and pathology, where it is especially important because of the limited capacity adult neurons to proliferate or be replaced. The concept used simple as there were just two three types, so we had work out which type was involved in our particular pathology then block it. However, now know that are at least a dozen ways for die, blocking mechanism may not prevent from dying, non-neuronal cells also contribute neuronal death. We review here mechanisms by intrinsic extrinsic apoptosis, oncosis, necroptosis, parthanatos, ferroptosis, sarmoptosis, autophagic death, autosis, autolysis, paraptosis, pyroptosis, phagoptosis, mitochondrial permeability transition. next explore development, those induced axotomy, aberrant cell-cycle reentry, glutamate (excitoxicity oxytosis), loss connected neurons, aggregated proteins unfolded protein response, oxidants, inflammation, microglia. reassess forms occur stroke Alzheimer’s disease, most pathologies involving discuss why has been difficult pinpoint involved, if matters, molecular overlap interplay between subroutines, therapeutic implications these multiple overlapping

Язык: Английский

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Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Cell Metabolism, Год журнала: 2018, Номер 27(3), С. 529 - 547

Опубликована: Март 1, 2018

Язык: Английский

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NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential

Signal Transduction and Targeted Therapy, Год журнала: 2020, Номер 5(1)

Опубликована: Окт. 7, 2020

Abstract Nicotinamide adenine dinucleotide (NAD + ) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells adapt environmental changes including nutrient perturbation, genotoxic factors, circadian disorder, infection, inflammation xenobiotics. These effects are mainly achieved by driving effect of NAD on metabolic pathways enzyme cofactors transferring hydrogen in oxidation-reduction reactions. Besides, multiple -dependent enzymes involved physiology either post-synthesis chemical modification DNA, RNA proteins, or releasing second messenger cyclic ADP-ribose (cADPR) NAADP . Prolonged disequilibrium metabolism disturbs physiological functions, resulting diseases diseases, cancer, aging neurodegeneration disorder. In this review, we summarize recent advances our understanding molecular mechanisms -regulated responses stresses, contribution deficiency various via manipulating cellular communication networks potential new avenues for therapeutic intervention.

Язык: Английский

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The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

Neuron, Год журнала: 2017, Номер 93(6), С. 1334 - 1343.e5

Опубликована: Март 1, 2017

Язык: Английский

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NAD+ homeostasis in health and disease

Nature Metabolism, Год журнала: 2020, Номер 2(1), С. 9 - 31

Опубликована: Янв. 20, 2020

Язык: Английский

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SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

Neuron, Год журнала: 2021, Номер 109(7), С. 1118 - 1136.e11

Опубликована: Март 2, 2021

Язык: Английский

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Programmed axon degeneration: from mouse to mechanism to medicine

Nature reviews. Neuroscience, Год журнала: 2020, Номер 21(4), С. 183 - 196

Опубликована: Март 9, 2020

Язык: Английский

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Role of NAD+ in regulating cellular and metabolic signaling pathways

Molecular Metabolism, Год журнала: 2021, Номер 49, С. 101195 - 101195

Опубликована: Фев. 18, 2021

Nicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in every living cell, is involved myriad of metabolic processes associated with cellular bioenergetics. For this reason, NAD+ often studied the context aging, cancer, and neurodegenerative disorders. Cellular depletion compromised adaptive stress responses, impaired neuronal plasticity, DNA repair, senescence. Increasing evidence has shown efficacy boosting levels using precursors various diseases. This review provides comprehensive understanding into role aging other pathologies discusses potential therapeutic targets. An alteration NAD+/NADH ratio or pool size can lead to derailment biological system contribute disorders, tumorigenesis. Due varied distribution different locations within cells, direct NAD+-dependent humans remains unestablished. In regard, longitudinal studies are needed quantify its related metabolites. Future research should focus on measuring fluxes through pathways synthesis degradation.

Язык: Английский

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TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes

Current Biology, Год журнала: 2018, Номер 28(3), С. 421 - 430.e4

Опубликована: Янв. 25, 2018

Язык: Английский

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