Spatiotemporal dynamics of noradrenaline during learned behaviour

Nature, Год журнала: 2022, Номер 606(7915), С. 732 - 738

Опубликована: Июнь 1, 2022

Язык: Английский

---

Physical activity for cognitive health promotion: An overview of the underlying neurobiological mechanisms

Ageing Research Reviews, Год журнала: 2023, Номер 86, С. 101868 - 101868

Опубликована: Фев. 2, 2023

Язык: Английский

---

Gradients of neurotransmitter receptor expression in the macaque cortex

Nature Neuroscience, Год журнала: 2023, Номер 26(7), С. 1281 - 1294

Опубликована: Июнь 19, 2023

Abstract Dynamics and functions of neural circuits depend on interactions mediated by receptors. Therefore, a comprehensive map receptor organization across cortical regions is needed. In this study, we used in vitro autoradiography to measure the density 14 neurotransmitter types 109 areas macaque cortex. We integrated data with anatomical, genetic functional connectivity into common space. uncovered principal gradient expression per neuron. This aligns hierarchy from sensory cortex higher cognitive areas. A second gradient, driven serotonin 5-HT 1A receptors, peaks anterior cingulate, default mode salience networks. found similar pattern human brain. Thus, may be promising translational model serotonergic processing disorders. The gradients enable rapid, reliable information slow, flexible integration

Язык: Английский

---

Neuromodulation of hippocampal long-term synaptic plasticity

Current Opinion in Neurobiology, Год журнала: 2018, Номер 54, С. 37 - 43

Опубликована: Сен. 10, 2018

Multiple neuromodulators including acetylcholine, noradrenaline, dopamine and serotonin are released in response to uncertainty focus attention on events where the predicted outcome does not match observed reality. In these situations, internal representations need be updated, a process that requires long-term synaptic plasticity. Through variety of common divergent mechanisms, it is recently shown all facilitate induction and/or expression plasticity within hippocampus. Under physiological conditions, this may critical for suprathreshold endowing with gating function providing mechanism by which enable targeted updating memory relevant information improve accuracy future predictions.

Язык: Английский

---

An Update on the Role of Serotonin and its Interplay with Dopamine for Reward

Frontiers in Human Neuroscience, Год журнала: 2017, Номер 11

Опубликована: Окт. 11, 2017

The specific role of serotonin and its interplay with dopamine (DA) in adaptive, reward guided behavior as well drug dependance, still remains elusive. Recently, novel methods allowed cell type anatomical, functional interventional analyses serotonergic dopaminergic circuits, promising significant advancement understanding their roles. Furthermore, it is increasingly recognized that co-release neurotransmitters functionally relevant, which required order to interpret results pharmacological studies relationship neural recordings. Here, we review recent animal employing such techniques the aim connect effects observed human subjective drugs. It appears additive effect DA conveys related information subjectively highly euphorizing. Neither nor alone have an effect. This coincides optogenetically targeted recordings mice, where system codes prediction errors (PE), mainly unsigned PE. Overall, this pattern indicates joint activity between both systems carries essential invites parallel investigation neurotransmitter systems.

Язык: Английский

---

Activation of serotonin neurons promotes active persistence in a probabilistic foraging task

Nature Communications, Год журнала: 2018, Номер 9(1)

Опубликована: Март 2, 2018

Abstract The neuromodulator serotonin (5-HT) has been implicated in a variety of functions that involve patience or impulse control. Many these effects are consistent with long-standing theory 5-HT promotes behavioral inhibition, motivational bias favoring passive over active behaviors. To further test this idea, we studied the impact probabilistic foraging task, which mice must learn statistics environment and infer when to leave depleted site for next. Critically, were required actively nose-poke order exploit given site. We show optogenetic activation neurons dorsal raphe nucleus increases willingness attempt reward before giving up. These results indicate inhibition is not an adequate description function suggest unified account be based on higher-order function.

Язык: Английский

---

Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons

eLife, Год журнала: 2017, Номер 6

Опубликована: Фев. 14, 2017

Serotonin (5-HT) is associated with mood and motivation but the function of endogenous 5-HT remains controversial. Here, we studied impact phasic optogenetic activation neurons in mice over time scales from seconds to weeks. We found that activating dorsal raphe nucleus (DRN) induced a strong suppression spontaneous locomotor behavior open field rapid kinetics (onset ≤1 s). Inhibition locomotion was independent measures anxiety or motor impairment could be overcome by motivational drive. Repetitive place-contingent pairing caused neither place preference nor aversion. However, repeated 15 min daily stimulation persistent increase emerge three These results show transients have opposing short long-term effects on appear arise underlying factors motivate actions.

Язык: Английский

---

Phasic Activation of Dorsal Raphe Serotonergic Neurons Increases Pupil Size

Current Biology, Год журнала: 2020, Номер 31(1), С. 192 - 197.e4

Опубликована: Ноя. 12, 2020

Transient variations in pupil size (PS) under constant luminance are coupled to rapid changes arousal state,1Reimer J. Froudarakis E. Cadwell C.R. Yatsenko D. Denfield G.H. Tolias A.S. Pupil fluctuations track fast switching of cortical states during quiet wakefulness.Neuron. 2014; 84: 355-362Abstract Full Text PDF PubMed Scopus (275) Google Scholar, 2McGinley M.J. David S.V. McCormick D.A. Cortical membrane potential signature optimal for sensory signal detection.Neuron. 2015; 87: 179-192Abstract (280) 3de Gee J.W. Colizoli O. Kloosterman N.A. Knapen T. Nieuwenhuis S. Donner T.H. Dynamic modulation decision biases by brainstem systems.eLife. 2017; 6: e23232Crossref (89) Scholar which have been interpreted as vigilance,4Yüzgeç Ö. Prsa M. Zimmermann R. Huber Size Coupling States Protects the Stability Deep Sleep via Parasympathetic Modulation.Curr. Biol. 2018; 28: 392-400.e3Abstract (35) salience,5Wang C.-A. Munoz D.P. A circuit orienting responses: implications cognitive size.Curr. Opin. Neurobiol. 33: 134-140Crossref (129) or a surprise signal.6Preuschoff K. 't Hart B.M. Einhäuser W. Dilation Signals Surprise: Evidence Noradrenaline's Role Decision Making.Front. Neurosci. 2011; 5: 115Crossref (226) 7Kloosterman Meindertsma van Loon A.M. Lamme V.A.F. Bonneh Y.S. tracks perceptual content and surprise.Eur. 41: 1068-1078Crossref (70) 8de Correa C. Weaver Gaal dilation P3 reflect subjective about outcome.bioRxiv. 2020; https://doi.org/10.1101/2020.06.25.164962Crossref (0) Neural control such presumably involves multiple brain regions5Wang Scholar,9Joshi Li Y. Kalwani R.M. Gold J.I. Relationships between Diameter Neuronal Activity Locus Coeruleus, Colliculi, Cingulate Cortex.Neuron. 2016; 89: 221-234Abstract (456) 10Nelson A. Mooney The Basal Forebrain Motor Cortex Provide Convergent yet Distinct Movement-Related Inputs Auditory 90: 635-648Abstract (68) 11Ebitz R.B. Platt M.L. activity primate dorsal anterior cingulate cortex signals task conflict predicts adjustments pupil-linked arousal.Neuron. 85: 628-640Abstract (101) neuromodulatory systems,3de Scholar,12Reimer McGinley Liu Rodenkirch Wang Q. adrenergic cholinergic cortex.Nat. Commun. 7: 13289Crossref (249) Scholar,13Joshi Window on Substrates Cognition.Trends Cogn. Sci. 24: 466-480Abstract (32) but it is often associated with phasic noradrenergic system.9Joshi Scholar,14Breton-Provencher V. Sur Active locus coeruleus GABAergic circuit.Nat. 2019; 22: 218-228Crossref (61) Scholar,15Aston-Jones G. Cohen J.D. An integrative theory coeruleus-norepinephrine function: adaptive gain performance.Annu. Rev. 2005; 403-450Crossref (2202) Serotonin (5-HT), neuromodulator also implicated aspects arousal16Frazer Hensler J.G. Involvement Physiological Function Behavior.in: Siegel G.J. Agranoff B.W. Albers R.W. Basic Neurochemistry: Molecular, cellular Medical Aspects. Lippincott-Raven, 1999: 264-268Google sleep-wake transitions,17Brown R.E. Basheer McKenna J.T. Strecker McCarley Control sleep wakefulness.Physiol. 2012; 92: 1087-1187Crossref (685) motivational state regulation,18Meyniel F. Goodwin G.M. Deakin Klinge MacFadyen Milligan H. Mullings Pessiglione Gaillard specific role serotonin overcoming effort cost.eLife. e17282Crossref (40) signaling unexpected events,19Matias Lottem Dugué G.P. Mainen Z.F. patterns neurons underlying flexibility.eLife. e20552Crossref (74) seems affect PS,20Prow M.R. Martin K.F. Heal D.J. 8-OH-DPAT-induced mydriasis mice: pharmacological characterisation.Eur. Pharmacol. 1996; 317: 21-28Crossref (22) 21Vitiello B. Hill Mack Molchan Martinez Murphy D.L. Sunderland Cognitive behavioral effects cholinergic, dopaminergic, serotonergic blockade humans.Neuropsychopharmacol. 1997; 16: 15-24Crossref (85) 22Schmid Enzler Gasser P. Grouzmann Preller K.H. Vollenweider F.X. Brenneisen Müller Borgwardt Liechti M.E. Acute Effects Lysergic Acid Diethylamide Healthy Subjects.Biol. Psychiatry. 78: 544-553Abstract (159) 23Weinberg-Wolf Fagan Anderson Tringides Dal Monte Chang S.W.C. 5-hydroxytryptophan attention central neurochemistry rhesus macaque.Neuropsychopharmacol. 43: 1589-1598Crossref (11) 24Yu Ramage A.G. Koss M.C. Pharmacological studies pupillary anesthetized rats.Eur. 2004; 489: 207-213Crossref (24) these not investigated detail. Here we show that 5-HT neuron stimulation causes transient PS changes. We used optogenetic activation raphe nucleus (DRN) head-fixed mice performing foraging task. 5-HT-driven modulations were maintained throughout photostimulation period sustained few seconds after end stimulation. found no evidence increase resulted from interactions variables, locomotion licking. Furthermore, observed effect depended level environmental uncertainty, consistent idea could report signal.19Matias These results advance our understanding PS, revealing tight relationship PS.

Язык: Английский

---

Pivotal mental states

Journal of Psychopharmacology, Год журнала: 2020, Номер 35(4), С. 319 - 352

Опубликована: Ноя. 11, 2020

This paper introduces a new construct, the 'pivotal mental state', which is defined as hyper-plastic state aiding rapid and deep learning that can mediate psychological transformation. We believe this construct bears relevance to broad range of psychiatric phenomena. argue pivotal states serve an important evolutionary function, is, aid transformation when actual or perceived environmental pressures demand this. cite evidence chronic stress neurotic traits are primers for state, whereas acute be trigger. Inspired by research with serotonin 2A receptor agonist psychedelics, we highlight how activity at particular robustly reliably induce states, but capacity inherent property human brain itself. Moreover, hypothesize serotonergic psychedelics hijack system has evolved its need sensed. breadth evidences linking via variety inducers, upregulated (e.g. availability and/or binding receptor) 5-HT release, activate primed state. The model multi-level, specific molecular gateway (increased signaling) inception mind enhanced rate associative potential mediation

Язык: Английский

---

Input–output organization of the mouse claustrum

The Journal of Comparative Neurology, Год журнала: 2018, Номер 526(15), С. 2428 - 2443

Опубликована: Сен. 25, 2018

Abstract Progress in determining the precise organization and function of claustrum (CLA) has been hindered by difficulty reliably targeting these neurons. To overcome this, we used a projection‐based strategy to selectively label CLA principal Combined with adeno‐associated virus (AAV) monosynaptic rabies tracing techniques, systematically examined pre‐synaptic input axonal output this structure. We found that neurons projecting retrosplenial cortex (RSP) collateralize extensively innervate variety higher‐order cortical regions. No subcortical labeling was found, exception sparse terminals basolateral amygdala (BLA). This pattern similar cingulate‐ visual cortex‐projecting neurons, suggesting common scheme among projection‐defined populations. Rabies directly demonstrated widespread synaptic inputs RSP‐projecting from both areas. The strongest arose classically defined limbic regions, including medial prefrontal cortex, anterior cingulate, BLA, ventral hippocampus, neuromodulatory systems such as dorsal raphe cholinergic basal forebrain. These results suggest may integrate information related emotional salience stimuli globally modulate state broadcasting its uniformly across higher cognitive centers.

Язык: Английский

---