Sub-second Dopamine and Serotonin Signaling in Human Striatum during Perceptual Decision-Making

Neuron, Год журнала: 2020, Номер 108(5), С. 999 - 1010.e6

Опубликована: Окт. 12, 2020

Recent animal research indicates that dopamine and serotonin, neuromodulators traditionally linked to appetitive aversive processes, are also involved in sensory inference decisions based on such inference. We tested this hypothesis humans by monitoring sub-second striatal serotonin signaling during a visual motion discrimination task separates uncertainty from decision difficulty factorial design. Caudate nucleus recordings (n = 4) revealed multi-scale encoding: three participants, tracked uncertainty, and, one participant, both deviations expected trial transitions within our Putamen 1) supported cognition-action separation between caudate putamen—a sub-division unique primates—with tracking times. These first-of-their-kind observations the human brain reveal role for non-reward-based aspects of cognition action.

Язык: Английский

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Sensation during Active Behaviors

Journal of Neuroscience, Год журнала: 2017, Номер 37(45), С. 10826 - 10834

Опубликована: Ноя. 8, 2017

A substantial portion of our sensory experience happens during active behaviors such as walking around or paying attention. How do systems work behaviors? Neural processing in can be shaped by behavior multiple ways ranging from a modulation responsiveness sharpening tuning to dynamic change response properties functional connectivity. Here, we review recent findings on the different systems: insect vision, rodent thalamus, and cortices. We discuss circuit-level mechanisms that might lead these modulations their potential role function. Finally, highlight open questions future perspectives this exciting new field.

Язык: Английский

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A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory

Neuron, Год журнала: 2019, Номер 103(3), С. 489 - 505.e7

Опубликована: Июнь 13, 2019

Highlights•Fear learning selectively engages the anatomically distinct DRN→BA 5-HT pathway•The pathway bidirectionally modulates fear and extinction•The sculpts fear-associated neuronal activity in BA•The expresses VGluT3 but drives via BA 5-HT1A/2A receptorsSummaryDespite a wealth of clinical preclinical data implicating serotonin (5-HT) system fear-related affective disorders, precise definition this neuromodulator's role remains elusive. Using convergent anatomical functional approaches, we interrogate contribution to basal amygdala (BA) inputs from dorsal raphe nucleus (DRN). We show is engaged during memory formation retrieval, these projections facilitates impairs extinction. The amplifies firing theta power phase-locking. Although recruits co-expressing DRN neurons, fear-potentiating influence requires signaling at receptors. Input-output mapping illustrates how connected with other brain regions that mediate fear. These findings reveal discrete circuit orchestrates broader neural network calibrate aversive memory.Graphical abstract

Язык: Английский

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Belief state representation in the dopamine system

Nature Communications, Год журнала: 2018, Номер 9(1)

Опубликована: Май 8, 2018

Abstract Learning to predict future outcomes is critical for driving appropriate behaviors. Reinforcement learning (RL) models have successfully accounted such learning, relying on reward prediction errors (RPEs) signaled by midbrain dopamine neurons. It has been proposed that when sensory data provide only ambiguous information about which state an animal in, it can based a set of probabilities assigned hypothetical states (called the belief state). Here we examine how RPEs and subsequent are regulated under uncertainty. Mice first trained in task with two potential defined different amounts. During testing, intermediate-sized rewards given rare trials. Dopamine activity non-monotonic function size, consistent RL operating states. Furthermore, magnitude responses quantitatively predicts changes behavior. These results establish role inference RL.

Язык: Английский

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Distinct temporal difference error signals in dopamine axons in three regions of the striatum in a decision-making task

eLife, Год журнала: 2020, Номер 9

Опубликована: Дек. 21, 2020

Different regions of the striatum regulate different types behavior. However, how dopamine signals differ across striatal and regulates behaviors remain unclear. Here, we compared axon activity in ventral, dorsomedial, dorsolateral striatum, while mice performed a perceptual value-based decision task. Surprisingly, was similar all three areas. At glance, multiplexed variables such as stimulus-associated values, confidence, reward feedback at phases Our modeling demonstrates, however, that these modulations can be inclusively explained by moment-by-moment changes expected reward, is temporal difference error. A major between areas overall level responses: responses were positively shifted, lacking inhibitory to negative prediction errors. The differences put specific constraints on properties controlled regions.

Язык: Английский

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