Phasic Activation of Dorsal Raphe Serotonergic Neurons Increases Pupil Size

Current Biology, Год журнала: 2020, Номер 31(1), С. 192 - 197.e4

Опубликована: Ноя. 12, 2020

Transient variations in pupil size (PS) under constant luminance are coupled to rapid changes arousal state,1Reimer J. Froudarakis E. Cadwell C.R. Yatsenko D. Denfield G.H. Tolias A.S. Pupil fluctuations track fast switching of cortical states during quiet wakefulness.Neuron. 2014; 84: 355-362Abstract Full Text PDF PubMed Scopus (275) Google Scholar, 2McGinley M.J. David S.V. McCormick D.A. Cortical membrane potential signature optimal for sensory signal detection.Neuron. 2015; 87: 179-192Abstract (280) 3de Gee J.W. Colizoli O. Kloosterman N.A. Knapen T. Nieuwenhuis S. Donner T.H. Dynamic modulation decision biases by brainstem systems.eLife. 2017; 6: e23232Crossref (89) Scholar which have been interpreted as vigilance,4Yüzgeç Ö. Prsa M. Zimmermann R. Huber Size Coupling States Protects the Stability Deep Sleep via Parasympathetic Modulation.Curr. Biol. 2018; 28: 392-400.e3Abstract (35) salience,5Wang C.-A. Munoz D.P. A circuit orienting responses: implications cognitive size.Curr. Opin. Neurobiol. 33: 134-140Crossref (129) or a surprise signal.6Preuschoff K. 't Hart B.M. Einhäuser W. Dilation Signals Surprise: Evidence Noradrenaline's Role Decision Making.Front. Neurosci. 2011; 5: 115Crossref (226) 7Kloosterman Meindertsma van Loon A.M. Lamme V.A.F. Bonneh Y.S. tracks perceptual content and surprise.Eur. 41: 1068-1078Crossref (70) 8de Correa C. Weaver Gaal dilation P3 reflect subjective about outcome.bioRxiv. 2020; https://doi.org/10.1101/2020.06.25.164962Crossref (0) Neural control such presumably involves multiple brain regions5Wang Scholar,9Joshi Li Y. Kalwani R.M. Gold J.I. Relationships between Diameter Neuronal Activity Locus Coeruleus, Colliculi, Cingulate Cortex.Neuron. 2016; 89: 221-234Abstract (456) 10Nelson A. Mooney The Basal Forebrain Motor Cortex Provide Convergent yet Distinct Movement-Related Inputs Auditory 90: 635-648Abstract (68) 11Ebitz R.B. Platt M.L. activity primate dorsal anterior cingulate cortex signals task conflict predicts adjustments pupil-linked arousal.Neuron. 85: 628-640Abstract (101) neuromodulatory systems,3de Scholar,12Reimer McGinley Liu Rodenkirch Wang Q. adrenergic cholinergic cortex.Nat. Commun. 7: 13289Crossref (249) Scholar,13Joshi Window on Substrates Cognition.Trends Cogn. Sci. 24: 466-480Abstract (32) but it is often associated with phasic noradrenergic system.9Joshi Scholar,14Breton-Provencher V. Sur Active locus coeruleus GABAergic circuit.Nat. 2019; 22: 218-228Crossref (61) Scholar,15Aston-Jones G. Cohen J.D. An integrative theory coeruleus-norepinephrine function: adaptive gain performance.Annu. Rev. 2005; 403-450Crossref (2202) Serotonin (5-HT), neuromodulator also implicated aspects arousal16Frazer Hensler J.G. Involvement Physiological Function Behavior.in: Siegel G.J. Agranoff B.W. Albers R.W. Basic Neurochemistry: Molecular, cellular Medical Aspects. Lippincott-Raven, 1999: 264-268Google sleep-wake transitions,17Brown R.E. Basheer McKenna J.T. Strecker McCarley Control sleep wakefulness.Physiol. 2012; 92: 1087-1187Crossref (685) motivational state regulation,18Meyniel F. Goodwin G.M. Deakin Klinge MacFadyen Milligan H. Mullings Pessiglione Gaillard specific role serotonin overcoming effort cost.eLife. e17282Crossref (40) signaling unexpected events,19Matias Lottem Dugué G.P. Mainen Z.F. patterns neurons underlying flexibility.eLife. e20552Crossref (74) seems affect PS,20Prow M.R. Martin K.F. Heal D.J. 8-OH-DPAT-induced mydriasis mice: pharmacological characterisation.Eur. Pharmacol. 1996; 317: 21-28Crossref (22) 21Vitiello B. Hill Mack Molchan Martinez Murphy D.L. Sunderland Cognitive behavioral effects cholinergic, dopaminergic, serotonergic blockade humans.Neuropsychopharmacol. 1997; 16: 15-24Crossref (85) 22Schmid Enzler Gasser P. Grouzmann Preller K.H. Vollenweider F.X. Brenneisen Müller Borgwardt Liechti M.E. Acute Effects Lysergic Acid Diethylamide Healthy Subjects.Biol. Psychiatry. 78: 544-553Abstract (159) 23Weinberg-Wolf Fagan Anderson Tringides Dal Monte Chang S.W.C. 5-hydroxytryptophan attention central neurochemistry rhesus macaque.Neuropsychopharmacol. 43: 1589-1598Crossref (11) 24Yu Ramage A.G. Koss M.C. Pharmacological studies pupillary anesthetized rats.Eur. 2004; 489: 207-213Crossref (24) these not investigated detail. Here we show that 5-HT neuron stimulation causes transient PS changes. We used optogenetic activation raphe nucleus (DRN) head-fixed mice performing foraging task. 5-HT-driven modulations were maintained throughout photostimulation period sustained few seconds after end stimulation. found no evidence increase resulted from interactions variables, locomotion licking. Furthermore, observed effect depended level environmental uncertainty, consistent idea could report signal.19Matias These results advance our understanding PS, revealing tight relationship PS.

Язык: Английский

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Moving beyond belief: A narrative review of potential biomarkers for transcutaneous vagus nerve stimulation

Psychophysiology, Год журнала: 2020, Номер 57(6)

Опубликована: Март 23, 2020

Abstract Transcutaneous vagus nerve stimulation (tVNS) is a non‐invasive neurostimulation technique that currently being tested as potential treatment for myriad of neurological and psychiatric disorders. However, the working mechanisms underlying tVNS are poorly understood it remains unclear whether activates every participant. Finding biological marker imperative, can help guide research on clinical applications inform researchers optimal sites parameters to further optimize efficacy. In this narrative review, we discuss five biomarkers review available evidence these markers both invasive tVNS. While some hold promise from theoretical perspective, none provide clear definitive indications increases vagal activity or augments in locus coeruleus‐noradrenaline network. We conclude by providing several recommendations how tackle challenges opportunities when researching effects

Язык: Английский

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Functional Organization of the Sympathetic Pathways Controlling the Pupil: Light-Inhibited and Light-Stimulated Pathways

Frontiers in Neurology, Год журнала: 2018, Номер 9

Опубликована: Дек. 18, 2018

Pupil diameter reflects the balance between opposing sympathetic and parasympathetic outputs to iris. dilation is mediated by a output acting in opposition parasympathetically pupil constriction. While light stimulates output, giving rise reflex, it has dual effect on output: can both inhibit stimulate it. Light-inhibited light-stimulated pathways (LISPs LSSPs) mediate opposite effects of activity. Two LISPs two LSSPs are described. The pretectum/PAG pathway runs from pretectum, via periaqueductal grey (PAG), premotor neurones (SympPN) paraventricular nucleus (PVN) hypothalamus, rostral ventrolateral medulla (RVLM), locus coeruleus (LC), dorsal raphe (DRN). Some these SympPN project preganglionic that innervate iris superior cervical ganglion (SCG) projecting SCN/PVN overlaps with controlling melatonin synthesis: suprachiasmatic (SCN) PVN projects pupil-controlling spinal cord. LISPs, attenuating activity, allow unimpeded operation for reflex. noradrenergic serotonergic pathways. LSSP SCN, dorsomedial hypothalamus (DMH) LC contains (ParaPN). cord where they excitatory α1-adrenoceptors, whereas ParaPN Edinger-Westphal reflex pathway, inhibitory α2-adrenoceptors. hub DRN light-sensitive, directly indirectly (via an orexinergic input). latent mydriatic be unmasked drugs either or By light-evoked constriction, may diurnal animals funtion during daytime. widespread connections neural networks variety functions, such as sleep/arousal, pain fear/anxiety. Many physiological psychological variables modulate function this pathway.

Язык: Английский

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Local cortical desynchronization and pupil-linked arousal differentially shape brain states for optimal sensory performance

eLife, Год журнала: 2019, Номер 8

Опубликована: Дек. 10, 2019

Instantaneous brain states have consequences for our sensation, perception, and behaviour. Fluctuations in arousal neural desynchronization likely pose perceptually relevant states. However, their relationship relative impact on perception is unclear. We here show that, at the single-trial level humans, local sensory cortex (expressed as time-series entropy) versus pupil-linked differentially perceptual processing. While we recorded electroencephalography (EEG) pupillometry data, stimuli of a demanding auditory discrimination task were presented into high or low via real-time closed-loop setup. Desynchronization distinctly influenced stimulus-evoked activity shaped behaviour displaying an inverted u-shaped relationship: States intermediate elicited minimal response bias fastest responses, while gave rise to highest sensitivity. Our results speak model which independent global jointly optimise processing performance.

Язык: Английский

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Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains

eLife, Год журнала: 2020, Номер 9

Опубликована: Июнь 16, 2020

Decisions are often made by accumulating ambiguous evidence over time. The brain’s arousal systems activated during such decisions. In previous work in humans, we found that evoked responses of decisions reported rapid dilations the pupil and track a suppression biases accumulation decision-relevant (de Gee et al., 2017). Here, show this arousal-related decision bias acts on both conservative liberal biases, generalizes from humans to mice, perceptual memory-based challenging sound-detection tasks, impact spontaneous or experimentally induced choice was reduced under high phasic arousal. Similar occurred when drawn memory. All these behavioral effects were explained biases. Our results point general principle interplay between decision-making.

Язык: Английский

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