Cell Reports,
Год журнала:
2018,
Номер
25(3), С. 651 - 662.e5
Опубликована: Окт. 1, 2018
It
remains
unclear
how
memory
engrams
are
altered
by
experience,
such
as
new
learning,
to
cause
forgetting.
Here,
we
report
that
short-term
aversive
in
Drosophila
is
encoded
and
retrieved
from
the
mushroom
body
output
neuron
MBOn-γ2α′1.
Pairing
an
odor
with
electric
shock
creates
a
robust
depression
calcium
response
of
MBOn-γ2α′1
increases
avoidance
paired
odor.
Electric
after
which
activates
cognate
dopamine
DAn-γ2α′1,
restores
properties
causes
behavioral
Conditioning
second
responses
previously
learned
while
depressing
newly
odor,
showing
learning
forgetting
can
occur
simultaneously.
Moreover,
optogenetic
activation
DAn-γ2α′1
sufficient
for
bidirectional
modulation
properties.
Thus,
single
DAn
drive
both
bidirectionally
modulating
cellular
trace.
The Journal of Comparative Neurology,
Год журнала:
2018,
Номер
526(16), С. 2585 - 2611
Опубликована: Авг. 7, 2018
Abstract
The
central
complex,
a
set
of
neuropils
in
the
center
insect
brain,
plays
crucial
role
spatial
aspects
sensory
integration
and
motor
control.
Stereotyped
neurons
interconnect
these
with
one
another
accessory
structures.
We
screened
over
5,000
Drosophila
melanogaster
GAL4
lines
for
expression
two
neuropils,
noduli
(NO)
complex
asymmetrical
body
(AB),
used
multicolor
stochastic
labeling
to
analyze
morphology,
polarity,
organization
individual
cells
subset
that
showed
neuropils.
identified
nine
NO
three
AB
cell
types
describe
them
here.
morphology
suggests
they
receive
input
primarily
lateral
lobe
send
output
each
six
paired
noduli.
demonstrate
is
bilateral
structure
which
exhibits
asymmetry
size
between
left
right
bodies.
show
directly
connect
target
both
ABs,
type
preferentially
innervates
AB.
propose
be
considered
neuropil
.
Finally,
we
present
highly
restricted
most
protocerebral
bridge,
NO,
types.
These
lines,
generated
using
split‐GAL4
method,
will
facilitate
anatomical
studies,
behavioral
assays,
physiological
experiments.
Cell Reports,
Год журнала:
2018,
Номер
25(3), С. 651 - 662.e5
Опубликована: Окт. 1, 2018
It
remains
unclear
how
memory
engrams
are
altered
by
experience,
such
as
new
learning,
to
cause
forgetting.
Here,
we
report
that
short-term
aversive
in
Drosophila
is
encoded
and
retrieved
from
the
mushroom
body
output
neuron
MBOn-γ2α′1.
Pairing
an
odor
with
electric
shock
creates
a
robust
depression
calcium
response
of
MBOn-γ2α′1
increases
avoidance
paired
odor.
Electric
after
which
activates
cognate
dopamine
DAn-γ2α′1,
restores
properties
causes
behavioral
Conditioning
second
responses
previously
learned
while
depressing
newly
odor,
showing
learning
forgetting
can
occur
simultaneously.
Moreover,
optogenetic
activation
DAn-γ2α′1
sufficient
for
bidirectional
modulation
properties.
Thus,
single
DAn
drive
both
bidirectionally
modulating
cellular
trace.
