Astrocyte function from information processing to cognition and cognitive impairment

Nature Neuroscience, Год журнала: 2019, Номер 22(2), С. 154 - 166

Опубликована: Янв. 21, 2019

Язык: Английский

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Diversity and Specificity of Astrocyte–neuron Communication

Neuroscience, Год журнала: 2018, Номер 396, С. 73 - 78

Опубликована: Ноя. 17, 2018

Язык: Английский

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Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity

Neuron, Год журнала: 2020, Номер 105(6), С. 1036 - 1047.e5

Опубликована: Янв. 15, 2020

Язык: Английский

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G_i/o protein‐coupled receptors inhibit neurons but activate astrocytes and stimulate gliotransmission

Glia, Год журнала: 2019, Номер 67(6), С. 1076 - 1093

Опубликована: Фев. 23, 2019

Abstract G protein‐coupled receptors (GPCRs) play key roles in intercellular signaling the brain. Their effects on cellular function have been largely studied neurons, but their functional consequences astrocytes are less known. Using both endogenous and chemogenetic approaches with DREADDs, we investigated of q i/o GPCR activation astroglial Ca 2+ ‐based activity, gliotransmitter release, neuronal electrical activity. We found that while led to neurons astrocytes, inhibition astrocytes. Astroglial by either or protein‐mediated stimulated which increased excitability. Additionally, DREADDs vivo astrocyte activity modified network Present results reveal additional complexity excitatory inhibitory neurotransmitters astroglia‐neuron operation brain function.

Язык: Английский

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G-Protein-Coupled Receptors in Astrocyte–Neuron Communication

Neuroscience, Год журнала: 2020, Номер 456, С. 71 - 84

Опубликована: Март 26, 2020

Язык: Английский

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The role of astrocyte‐mediated plasticity in neural circuit development and function

Neural Development, Год журнала: 2021, Номер 16(1)

Опубликована: Янв. 7, 2021

Abstract Neuronal networks are capable of undergoing rapid structural and functional changes called plasticity, which essential for shaping circuit function during nervous system development. These range from short-term modifications on the order milliseconds, to long-term rearrangement neural architecture that could last lifetime organism. Neural plasticity is most prominent development, yet also plays a critical role memory formation, behavior, disease. Therefore, it define characterize mechanisms underlying onset, duration, form plasticity. Astrocytes, numerous glial cell type in human system, integral elements synapses components network can coordinate activity at circuit-wide level. Moreover, their arrival CNS late embryogenesis correlates onset sensory-evoked activity, making them an interesting target studies. Technological advancements decade have uncovered astrocytes as regulators assembly function. Here, we provide brief historical perspective our understanding review latest advances astroglia regulating development homeostasis.

Язык: Английский

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Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Май 31, 2021

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. The mechanisms underlying ASD are unclear. Astrocyte alterations noted in patients and animal models. However, whether astrocyte dysfunction causal or consequential to ASD-like phenotypes mice unresolved. Type 2 inositol 1,4,5-trisphosphate 6 receptors (IP3R2)-mediated Ca2+ release from intracellular stores results the activation of astrocytes. Mutations IP3R2 gene associated with ASD. Here, we show that both IP3R2-null mutant astrocyte-specific conditional knockout display behaviors, such as atypical social interaction repetitive behavior. Furthermore, astrocyte-derived ATP modulates behavior through P2X2 prefrontal cortex possibly GABAergic synaptic transmission. These findings identify potential molecular player pathophysiology

Язык: Английский

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Astrocyte regulation of neural circuit activity and network states

Glia, Год журнала: 2022, Номер 70(8), С. 1455 - 1466

Опубликована: Апрель 22, 2022

Abstract Astrocytes are known to influence neuronal activity through different mechanisms, including the homeostatic control of extracellular levels ions and neurotransmitters exchange signaling molecules that regulate synaptic formation, structure, function. While a great effort done in past has defined many molecular mechanisms cellular processes involved astrocyte‐neuron interactions at level, consequences these network level vivo have only relatively recently been identified. This review describes discusses recent findings on regulatory effects astrocytes networks vivo. Accumulating but still limited, evidence indicates rhythmic synchronization as well brain states. These studies demonstrate critical contribution paving way for more thorough understanding bases

Язык: Английский

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Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells

Glia, Год журнала: 2023, Номер 71(6), С. 1383 - 1401

Опубликована: Фев. 17, 2023

Abstract The mammalian brain is a complex organ comprising neurons, glia, and more than 1 × 10 14 synapses. Neurons are heterogeneous group of electrically active cells, which form the framework circuitry brain. However, glial primarily divided into astrocytes, microglia, oligodendrocytes (OLs), oligodendrocyte precursor cells (OPCs), constitute approximately half all neural in central nervous system (CNS) mainly provide nutrition tropic support to neurons In last two decades, concept “tripartite synapses” has drawn great attention, emphasizes that astrocytes an integral part synapse regulate neuronal activity feedback manner after receiving signals. Since then, synaptic modulation by been extensively studied substantially revised. this review, we summarize latest significant findings on how particular, microglia OL lineage impact remodel structure function synapses Our review highlights cellular molecular aspects neuron‐glia crosstalk provides additional information aberrant communication between glia may contribute pathologies.

Язык: Английский

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Motile cilia modulate neuronal and astroglial activity in the zebrafish larval brain

Cell Reports, Год журнала: 2025, Номер 44(1), С. 115195 - 115195

Опубликована: Янв. 1, 2025

Язык: Английский

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