behaviorMate: An Intranet of Things Approach for Adaptable Control of Behavioral and Navigation-Based Experiments DOI Creative Commons
John C. Bowler, George Zakka, Hyun Choong Yong

и другие.

eLife, Год журнала: 2024, Номер unknown

Опубликована: Июль 11, 2024

Investigators conducting behavioral experiments often need precise control over the timing of delivery stimuli to subjects and collect times subsequent responses. Furthermore, investigators want fine-tuned how various multi-modal cues are presented. behaviorMate takes an “Intranet Things” approach, using a networked system hardware software components for achieving these goals. The outputs file with integrated timestamp-event pairs that can then format process their own analysis pipelines. We present overview electronic GUI application make up as well mechanical designs compatible experimental rigs provide reader ability set system. A wide variety paradigms supported, including goal-oriented learning, random foraging, context switching. demonstrate behaviorMate’s utility reliability range use cases from several published studies benchmark tests. Finally, we validation demonstrating different modalities hippocampal place field studies. Both treadmill burlap belt virtual reality running wheel were performed confirm efficacy flexibility approach. Previous solutions rely on proprietary systems may have large upfront costs or frameworks require customized be developed. uses open-source flexible configuration mitigate both concerns. has proven record head-fixed imaging could easily adopted task in situations.

Язык: Английский

The role of inhibitory circuits in hippocampal memory processing DOI
Lisa Topolnik, Suhel Tamboli

Nature reviews. Neuroscience, Год журнала: 2022, Номер 23(8), С. 476 - 492

Опубликована: Май 30, 2022

Язык: Английский

Процитировано

109
Large-Scale 3D Two-Photon Imaging of Molecularly Identified CA1 Interneuron Dynamics in Behaving Mice DOI Creative Commons
Tristan Geiller,

Bert Vancura,

Satoshi Terada

и другие.

Neuron, Год журнала: 2020, Номер 108(5), С. 968 - 983.e9

Опубликована: Окт. 5, 2020

Язык: Английский

Процитировано

125
Mouse color and wavelength-specific luminance contrast sensitivity are non-uniform across visual space DOI Creative Commons
Daniel J. Denman,

Jennifer Luviano,

Douglas R. Ollerenshaw

и другие.

eLife, Год журнала: 2018, Номер 7

Опубликована: Янв. 5, 2018

Mammalian visual behaviors, as well responses in the neural systems underlying these are driven by luminance and color contrast. With constantly improving tools for measuring activity cell-type-specific populations mouse during behavior, it is important to define extent of information that behaviorally accessible mouse. A non-uniform distribution cone opsins retina potentially complicates both sensitivity; opposing gradients short (UV-shifted) middle (blue/green) suggest discrimination wavelength-specific contrast sensitivity may differ with retinotopic location. Here we ask how mice can discriminate changes across visuotopic space. We found were able do so more broadly space than expected from cone-opsin distribution. also wavelength-band-specific differences sensitivity.

Язык: Английский

Процитировано

87
Global and subtype-specific modulation of cortical inhibitory neurons regulated by acetylcholine during motor learning DOI Creative Commons
Chi Ren, Kailong Peng,

Ruize Yang

и другие.

Neuron, Год журнала: 2022, Номер 110(14), С. 2334 - 2350.e8

Опубликована: Май 17, 2022

Язык: Английский

Процитировано

62
Inhibitory control of sharp-wave ripple duration during learning in hippocampal recurrent networks DOI

Bert Vancura,

Tristan Geiller, Andres Grosmark

и другие.

Nature Neuroscience, Год журнала: 2023, Номер 26(5), С. 788 - 797

Опубликована: Апрель 20, 2023

Язык: Английский

Процитировано

32
Stimulus novelty uncovers coding diversity in visual cortical circuits DOI Creative Commons
Marina Garrett, Peter A. Groblewski, Alex T. Piet

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Фев. 15, 2023

The detection of novel stimuli is critical to learn and survive in a dynamic environment. Though powerfully affect brain activity, their impact on specific cell types circuits not well understood. Disinhibition one candidate mechanism for novelty-induced enhancements activity. Here we characterize the stimulus novelty disinhibitory circuit components using longitudinal 2-photon calcium imaging Vip, Sst, excitatory populations mouse visual cortex. Mice behavioral task with that become highly familiar, then are tested both familiar stimuli. consistently perform stimuli, yet responses presentations omissions dramatically altered. Further, find modifies coding as information. At population level, direction these changes consistent engagement Vip-Sst circuit. single identify separate clusters cells unique patterns changes. This study accompanying open-access dataset reveals sensory representations cortical establishes key driver cellular functional diversity.

Язык: Английский

Процитировано

25
Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory DOI Creative Commons
Suhel Tamboli, Sanjay Singh,

Dimitry Topolnik

и другие.

Cell Reports, Год журнала: 2024, Номер 43(4), С. 114115 - 114115

Опубликована: Апрель 1, 2024

In the CA1 hippocampus, vasoactive intestinal polypeptide-expressing interneurons (VIP-INs) play a prominent role in disinhibitory circuit motifs. However, specific behavioral conditions that lead to disinhibition remain uncertain. To investigate relevance of VIP-IN activity, we employed wireless technologies allowing us monitor and manipulate their function freely behaving mice. Our findings reveal that, during spatial exploration new environments, VIP-INs hippocampal region become highly active, facilitating rapid encoding novel information. Remarkably, both pyramidal neurons (PNs) exhibit increased activity when encountering changes environment, including context- object-related alterations. Concurrently, somatostatin- parvalbumin-expressing inhibitory populations show an inverse relationship with PN revealing occurs on timescale seconds. Thus, VIP-IN-mediated may constitute crucial element novelty acquisition recognition memory.

Язык: Английский

Процитировано

13
Curiosity: primate neural circuits for novelty and information seeking DOI
Ilya E. Monosov

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(3), С. 195 - 208

Опубликована: Янв. 23, 2024

Язык: Английский

Процитировано

12
Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice DOI Creative Commons
Thomas Hainmueller, Aurore Cazala, Li-Wen Huang

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Янв. 24, 2024

Abstract The hippocampus is the brain’s center for episodic memories. Its subregions, dentate gyrus and CA1-3, are differentially involved in memory encoding recall. Hippocampal principal cells represent features like movement, space, context, but less known about GABAergic interneurons. Here, we performed two-photon calcium imaging of parvalbumin- somatostatin-expressing interneurons CA1-3 male mice exploring virtual environments. Parvalbumin-interneurons increased activity with running-speed reduced it novel Somatostatin-interneurons behaved similar to parvalbumin-expressing cells, their counterparts during rest Congruently, chemogenetic silencing parvalbumin-interneurons had prominent effects familiar contexts, while similarity granule cell representations between Our data indicate unique roles somatostatin-positive that distinct from those may support routing information.

Язык: Английский

Процитировано

10
Somatostatin and Somatostatin-Containing Interneurons—From Plasticity to Pathology DOI Creative Commons
Monika Liguz‐Lecznar, Grzegorz Dobrzański, Małgorzata Kossut

и другие.

Biomolecules, Год журнала: 2022, Номер 12(2), С. 312 - 312

Опубликована: Фев. 15, 2022

Despite the obvious differences in pathophysiology of distinct neuropsychiatric diseases or neurodegenerative disorders, some them share general but pivotal mechanisms, one which is disruption excitation/inhibition balance. Such an imbalance can be generated by changes inhibitory system, very often mediated somatostatin-containing interneurons (SOM-INs). In physiology, this group interneurons, as well somatostatin itself, profoundly shapes brain activity, thus influencing behavior and plasticity; however, number, density activity SOM-INs levels are found throughout many neurological conditions, both patients animal models. Here, we (1) briefly describe somatostatinergic characterizing neuropeptide its receptors functions, physiology circuitry SOM-INs; (2) summarize effects physiological processes pathological focusing primarily on learning-induced plasticity encompassing selected neuropsychological respectively. The presented data indicate somatostatinergic-system-mediated inhibition a substantial factor mechanisms neuroplasticity, disrupted plethora pathologies.

Язык: Английский

Процитировано

34