From perception to behavior: The neural circuits underlying prey hunting in larval zebrafish

Frontiers in Neural Circuits, Год журнала: 2023, Номер 17

Опубликована: Фев. 1, 2023

A key challenge for neural systems is to extract relevant information from the environment and make appropriate behavioral responses. The larval zebrafish offers an exciting opportunity studying these sensing processes sensory-motor transformations. Prey hunting instinctual behavior of that requires brain combine different attributes sensory input form motor outputs. Due its small size transparency allows optical recording whole-brain activity reveal mechanisms involved in prey capture. In this review we discuss how visual identify locate prey, circuits governing generation commands response can be modulated by internal states experience, some outstanding questions field.

Язык: Английский

---

Circuit mechanisms for colour vision in zebrafish

Current Biology, Год журнала: 2021, Номер 31(12), С. R807 - R820

Опубликована: Июнь 1, 2021

The use of spectral information in natural light to inform behaviour is one the oldest and most fundamental abilities visual systems. It long-predates animals' venture onto land, even appearance image-forming eyes. Accordingly, circuits for colour vision evolved under surface ancient oceans hundreds millions years. These aquatic beginnings fundamentally underpin, likely constrain, organisation modern In contrast our detailed circuit level understanding from diverse terrestrial vertebrates, however, comparatively little known about their counterparts. Here, I summarise some what neural fish, species-diverse group vertebrates. With a focus on zebrafish, will explore how computational strategies are linked statistics underwater world, study might help us understand general, including own

Язык: Английский

---

Evolution of the vertebrate motor system — from forebrain to spinal cord

Current Opinion in Neurobiology, Год журнала: 2021, Номер 71, С. 11 - 18

Опубликована: Авг. 24, 2021

A comparison of the vertebrate motor systems oldest group now living vertebrates (lamprey) with that mammals shows there are striking similarities not only in basic organization but also regard to synaptic properties, transmitters and neuronal properties. The lamprey dorsal pallium (cortex) has a motor, visual somatosensory area, basal ganglia, including dopamine system, organized virtually identical way rodents. This applies midbrain, brainstem spinal cord. However, during evolution additional capabilities such as for control foreleg/arms, hands fingers have evolved. findings suggest when evolutionary lineages became separate around 500 million years ago, blueprint system had already

Язык: Английский

---

Predation without direction selectivity

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(12)

Опубликована: Март 14, 2024

Across the animal kingdom, visual predation relies on motion-sensing neurons in superior colliculus (SC) and its orthologs. These exhibit complex stimulus preferences, including direction selectivity, which is thought to be critical for tracking unpredictable escape routes of prey. The source selectivity SC contested, contributions have not been tested experimentally. Here, we use type-specific cell removal show that narrow-field (NF) mouse guide predation. In vivo recordings demonstrate direction-selective responses NF cells are independent recently reported stimulus-edge effects. Monosynaptic retrograde tracing reveals receive synaptic input from ganglion cells. When eliminate retina adult mice, SC, cells, lost. However, eliminating retinal does affect hunting success or strategies even when removed after mice learned hunt, despite abolishing gaze-stabilizing optokinetic reflex. Thus, our results identify SC. They predation, an essential spatial orienting task, their revealing behavioral multiplexing neural feature preferences highlighting importance feature-selective manipulations neuroethology.

Язык: Английский

---

The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish

Neuron, Год журнала: 2024, Номер 112(7), С. 1150 - 1164.e6

Опубликована: Янв. 30, 2024

Animals constantly need to judge the valence of an object in their environment: is it potential food or a threat? The brain makes fundamental decisions on appropriate behavioral strategy by integrating external information from sensory organs and internal signals related physiological needs. For example, hungry animal may take more risks than satiated one when deciding approach avoid object. Using proteomic profiling approach, we identified Calmodulin-interacting peptide Pcp4a as key regulator foraging-related decisions. Food intake reduced abundance protein mRNA pcp4a via dopamine D2-like receptor-mediated repression adenylate cyclase. Accordingly, deleting gene made zebrafish larvae risk averse binary decision assay. Strikingly, neurons tectum became less responsive prey-like visual stimuli mutants, thus biasing behavior toward avoidance. This study pinpoints molecular mechanism modulating choice according state.

Язык: Английский

---

Spatial Cognition in Teleost Fish: Strategies and Mechanisms

Animals, Год журнала: 2021, Номер 11(8), С. 2271 - 2271

Опубликована: Июль 31, 2021

Teleost fish have been traditionally considered primitive vertebrates compared to mammals and birds in regard brain complexity behavioral functions. However, an increasing amount of evidence suggests that teleosts show advanced cognitive capabilities including spatial navigation skills parallel those land vertebrates. rely on a multiplicity sensory cues can use variety strategies for navigation, ranging from relatively simple body-centered orientation responses allocentric or “external world-centered” likely based map-like relational memory representations the environment. These distinct are separate mechanisms. For example, crucial center egocentric teleost is optic tectum, which be essential hub wider network responsible generation egocentrically referenced actions space. In contrast, other centers, such as dorsolateral telencephalic pallium fish, homologue hippocampal vertebrates, seem memory. Such hypothetical endow fish’s behavior with considerable navigational flexibility, allowing them, perform shortcuts detours.

Язык: Английский

---

Perspectives Organize Information in Mind and Nature: Empirical Findings of Point-View Perspective (P) in Cognitive and Material Complexity

Systems, Год журнала: 2022, Номер 10(3), С. 52 - 52

Опубликована: Апрель 19, 2022

The importance of perspective-taking crosses disciplines and is foundational to diverse phenomena such as point-of-view, scale, mindset, theory mind, opinion, belief, empathy, compassion, analysis, problem solving, etc. This publication gives predictions for a formal description point-view Perspectives (P) or the “P-rule”. makes P-rule systems, systems thinking consilience knowledge. It one four universals organization information whole. paper presents nine empirical studies in which subjects were asked complete task and/or answer question. samples vary each study (ranging from N = 407 34,398) are generalizable normal distribution US population. As was evident Cabrera, “These support—with high statistical significance—the made by DSRP Theory (Distinctions, Systems Relationships, Perspectives) including its: universality an observable phenomenon both mind (cognitive complexity) nature (material (i.e., parallelism); internal structures dynamics; mutual dependencies on other Distinctions, Systems, Relationships); role structural predictions; and, efficacy metacognitive skill”. These data suggest that observably empirically exist, universality, efficacy, parallelism (between cognitive material exist well. impact this it provides evidence perspective taking (“P-rule”) universal pattern/structure thinking, field scholarly debate often based invalidated opinioned frameworks; sets stage building field.

Язык: Английский

---

Input from torus longitudinalis drives binocularity and spatial summation in zebrafish optic tectum

BMC Biology, Год журнала: 2022, Номер 20(1)

Опубликована: Янв. 25, 2022

Abstract Background A continued effort in neuroscience aims to understand the way brain circuits consisting of diverse neuronal types generate complex behavior following sensory input. common feature vertebrate visual systems is that lower-order and higher-order areas are reciprocally connected. Feedforward projections confer responsiveness neurons while feedback likely serve modulate responses a context-dependent manner. Optic tectum largest first-order area zebrafish connected with torus longitudinalis (TL), second-order does not receive retinal functional role for from TL has been identified. Here we aim how this contributes processing. Results In study, demonstrate drive binocular integration spatial summation defined tectal circuit. We performed genetically targeted, cell type-specific imaging pyramidal (PyrNs) their two input neuron populations: ganglion cells (RGCs) TL. find PyrNs encode gradual changes scene luminance using complement three distinct response classes different light intensity ranges. Functional RGC inputs suggest these originate retina specifies PyrN classes. contrast, serves endow large, compound receptive fields span both hemifields. Conclusions These findings reveal novel driving PyrNs. The neural circuit describe generates population large tailored detecting scene.

Язык: Английский

---

Quantity as a Fish Views It: Behavior and Neurobiology

Frontiers in Neuroanatomy, Год журнала: 2022, Номер 16

Опубликована: Июль 14, 2022

An ability to estimate quantities, such as the number of conspecifics or size a predator, has been reported in vertebrates. Fish, particular zebrafish, may be instrumental advancing understanding magnitude cognition. We review here behavioral studies that have described ecological relevance quantity estimation fish and current status research aimed at investigating neurobiological bases these abilities. By combining methods with molecular genetics calcium imaging, involvement retina optic tectum documented for continuous quantities larval adult zebrafish brain, contributions thalamus dorsal-central pallium discrete brain. Evidence basic circuitry can now complemented extended make use transgenic lines deepen our cognition genetic levels.

Язык: Английский

---

Blind cavefish retain functional connectivity in the tectum despite loss of retinal input

Current Biology, Год журнала: 2022, Номер 32(17), С. 3720 - 3730.e3

Опубликована: Авг. 4, 2022

Sensory systems display remarkable plasticity and are under strong evolutionary selection. The Mexican cavefish, Astyanax mexicanus, consists of eyed river-dwelling surface populations multiple independent cave that have converged on eye loss, providing the opportunity to examine evolution sensory circuits in response environmental perturbation. Functional analysis across transgenic expressing GCaMP6s showed functional connectivity optic tectum largely did not differ between populations, except for selective loss negatively correlated activity within cavefish tectum, suggesting positively neural is resistant an evolved input from retina. Furthermore, surface-cave hybrid fish reveals changes genetically distinct those encoding loss. Together, these findings uncover components visual system establish use imaging A. mexicanus study circuit evolution.

Язык: Английский

---