Transformation of acoustic information to sensory decision variables in the parietal cortex

Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(2)

Опубликована: Янв. 4, 2023

The process by which sensory evidence contributes to perceptual choices requires an understanding of its transformation into decision variables. Here, we address this issue evaluating the neural representation acoustic information in auditory cortex-recipient parietal cortex, while gerbils either performed a two-alternative forced-choice discrimination task or they passively listened identical stimuli. During engagement, stimulus identity decoding performance from simultaneously recorded neurons significantly correlated with psychometric sensitivity. In contrast, during passive listening was reduced. Principal component and geometric analyses revealed emergence low-dimensional encoding linearly separable manifolds respect decision, but only engagement. These findings confirm that cortex mediates transition representations decision-related Finally, using clustering analysis, identified three functionally distinct subpopulations each encoded task-relevant separate temporal segments trial. Taken together, our demonstrate how integrate transform guide sound-driven decisions.

Язык: Английский

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Bidirectional brain-body interactions during natural story listening

Cell Reports, Год журнала: 2024, Номер 43(4), С. 114081 - 114081

Опубликована: Апрель 1, 2024

Narratives can synchronize neural and physiological signals between individuals, but the relationship these signals, underlying mechanism, is unclear. We hypothesized a top-down effect of cognition on arousal predicted that auditory narratives will drive not only brain also peripheral signals. find entrained gaze variation, saccade initiation, pupil size, heart rate. This consistent with autonomic function. bottom-up effect, whereby physiology affects arousal. Controlled breathing affected rate was by controlled saccades. Additionally, fluctuations in preceded size Gaze were all associated anterior-central Together, results suggest bidirectional causal effects function central circuits involved control

Язык: Английский

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Electrophysiological correlates of attention in the locus coeruleus–prelimbic cortex circuit during the rodent continuous performance test

Neuropsychopharmacology, Год журнала: 2023, Номер 49(3), С. 521 - 531

Опубликована: Авг. 10, 2023

Язык: Английский

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Adaptive tuning of human learning and choice variability to unexpected uncertainty

Science Advances, Год журнала: 2023, Номер 9(13)

Опубликована: Март 31, 2023

Human value–based decisions are notably variable under uncertainty. This variability is known to arise from two distinct sources: choices aimed at exploring available options and imprecise learning of option values due limited cognitive resources. However, whether these sources decision tuned their specific costs benefits remains unclear. To address this question, we compared the effects expected unexpected uncertainty on decision-making in same reinforcement task. Across large behavioral datasets, found that humans choose more variably between but simultaneously learn less imprecisely response Using simulations agents, demonstrate opposite adjustments reflect adaptive tuning exploration precision structure Together, findings indicate regulate not only how much they explore uncertain also precisely options.

Язык: Английский

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The Locus Coeruleus: Where Cognitive and Emotional Processing Meet the Eye

Springer eBooks, Год журнала: 2024, Номер unknown, С. 3 - 75

Опубликована: Янв. 1, 2024

Язык: Английский

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Saccade, pupil, and blink abnormalities in prodromal and manifest alpha-synucleinopathies

Journal of Parkinson s Disease, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Background Saccade, pupil, and blink control are impaired in patients with α-synucleinopathies (αSYN): Parkinson's disease (PD) multiple system atrophy (MSA). Isolated REM (rapid eye movement) Sleep Behavior Disorder (iRBD) is a prodromal stage of PD MSA prime candidate for investigating early oculo-pupillo-motor abnormalities that may precede or predict conversion to clinically manifest αSYN. Objective Determine whether saccade, responses iRBD normal similar those identified MSA. Methods Video-based eye-tracking was conducted 68 iRBD, 49 PD, 17 MSA, 95 healthy controls (CTRL) performing an interleaved pro-/anti-saccade task probed sensory, motor, cognitive processes involved movement control. Results Horizontal saccade behavior intact but abnormal patients, however, demonstrated reduced pupil dilation size, which closely resembled the changes found In group, extent these pupillary appeared correlate degree hyposmia reduction dopamine transporter imaging signal. Conclusions Pupil were present horizontal intact. Future longitudinal studies required determine from identify time window, relation conversion, when become abnormal.

Язык: Английский

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A circuit from the locus coeruleus to the anterior cingulate cortex modulates offspring interactions in mice

Cell Reports, Год журнала: 2023, Номер 42(7), С. 112771 - 112771

Опубликована: Июль 1, 2023

Social sensitivity to other individuals in distress is crucial for survival. The anterior cingulate cortex (ACC) a structure involved making behavioral choices and influenced by observed pain or distress. Nevertheless, our understanding of the neural circuitry underlying this incomplete. Here, we reveal unexpected sex-dependent activation ACC when parental mice respond distressed pups returning them nest ("pup retrieval"). We observe sex differences interactions between excitatory inhibitory neurons during care, inactivation increased pup neglect. Locus coeruleus (LC) releases noradrenaline retrieval, LC-ACC pathway disrupts care. conclude that maintains under LC modulation. propose ACC's involvement parenting presents an opportunity identify circuits support emotional others.

Язык: Английский

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Slow fluctuations in ongoing brain activity decrease in amplitude with ageing yet their impact on task-related evoked responses is dissociable from behavior

eLife, Год журнала: 2022, Номер 11

Опубликована: Май 24, 2022

In humans, ageing is characterized by decreased brain signal variability and increased behavioral variability. To understand how reduced segregates with variability, we investigated the association between reaction time evoked responses ongoing dynamics, in young (N=36) older adults (N=39). We studied electroencephalogram (EEG) pupil size fluctuations to characterize cortical arousal elicited a cued go/no-go task. Evoked were strongly modulated slow (<2 Hz) of signals, which presented power participants. Although was lower participants, once adjusted for effect fluctuations, equally variable both groups. Moreover, modulation caused had no impact on time, thereby explaining why although individuals, not. Finally, showed that adjusting critical unmask link neural behavior as well task-related EEG responses.

Язык: Английский

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Noise Correlations for Faster and More Robust Learning

Journal of Neuroscience, Год журнала: 2021, Номер 41(31), С. 6740 - 6752

Опубликована: Июнь 30, 2021

Distributed population codes are ubiquitous in the brain and pose a challenge to downstream neurons that must learn an appropriate readout. Here we explore possibility this learning problem is simplified through inductive biases implemented by stimulus-independent noise correlations constrain task-relevant dimensions. We test idea set of neural networks perform perceptual discrimination task. Correlations among similarly tuned units were manipulated independently overall signal-to-noise ratio how format stored information affects learning. Higher led faster more robust learning, favoring homogenous weights assigned within functionally similar pool, could emerge Hebbian When multiple discriminations learned simultaneously, across relevant feature dimensions sped whereas those irrelevant slowed it. Our results complement existing theory on demonstrating when such produced without significant degradation ratio, they can improve speed readout constraining it dimensions.SIGNIFICANCE STATEMENT Positive between theoretically reduce representational capacity brain, yet commonly observed, dynamically complex tasks, persist even well-trained animals. show correlations, embedded with fixed robustness which learned. In simple task naturally tasks require discriminations, encode dimension.

Язык: Английский

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Electrophysiological correlates of attention in the locus coeruleus - anterior cingulate cortex circuit during the rodent continuous performance test

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Апрель 20, 2023

ABSTRACT Sustained attention, the ability to focus on an activity or stimulus over time, is significantly impaired in many psychiatric disorders, and there remains a major unmet need treating attention. Continuous performance tests (CPTs) were developed measure sustained attention humans, non-human primates, rats, mice, similar neural circuits are engaged across species during CPT performance, supporting their use translational studies identify novel therapeutics. Here, we identified electrophysiological correlates of attentional touchscreen-based rodent (rCPT) locus coeruleus (LC) anterior cingulate cortex (ACC), two inter-connected regions that implicated processes. We used viral labeling molecular techniques demonstrate recruited LC-ACC projections rCPT, this recruitment increases with cognitive demand. implanted male mice depth electrodes within LC ACC for local field potential (LFP) recordings rCPT training, increase delta theta power, power correct responses rCPT. also found leads frequencies while gamma incorrect responses. These findings may represent biomarkers can be screen therapeutics drug discovery

Язык: Английский

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