Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology

Communications Biology, Год журнала: 2022, Номер 5(1)

Опубликована: Сен. 27, 2022

It is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar brain systems. Here, we carried out a multiscale contextualization of alterations cortical morphology across six major (autism spectrum disorder, attention deficit/hyperactivity depression obsessive-compulsive bipolar and schizophrenia). Our framework cross-referenced morphological anomalies with respect to myeloarchitecture cytoarchitecture, as well connectome neurotransmitter organization. Pooling disease-related effects on MRI-based thickness measures ENIGMA working groups, including total 28,546 participants (12,876 patients 15,670 controls), identified cortex-wide dimension changes described sensory-fugal pattern, paralimbic regions showing the most consistent conditions. The disease was closely related gradients microstructure axes, specifically variations in serotonin dopamine. Multiple sensitivity analyses confirmed robustness slight analytical choices. findings embed common structure scales organization, may provide insights into mechanisms transdiagnostic vulnerability.

Язык: Английский

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Correspondence of functional connectivity gradients across human isocortex, cerebellum, and hippocampus

Communications Biology, Год журнала: 2023, Номер 6(1)

Опубликована: Апрель 12, 2023

Gradient mapping is an important technique to summarize high dimensional biological features as low manifold representations in exploring brain structure-function relationships at various levels of the cerebral cortex. While recent studies have characterized major gradients functional connectivity several structures using this technique, very few systematically examined correspondence such across under a common systems-level framework. Using resting-state magnetic resonance imaging, here we show that organizing principles isocortex, and those cerebellum hippocampus relation can be described two gradients. We suggest similarity these meaningfully interpreted within computational framework based on predictive processing. The present results, specific hypotheses they suggest, represent step toward integrative account function.

Язык: Английский

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Gradients of Brain Organization: Smooth Sailing from Methods Development to User Community

Neuroinformatics, Год журнала: 2024, Номер unknown

Опубликована: Апрель 3, 2024

Язык: Английский

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Bringing machine learning to research on intellectual and developmental disabilities: taking inspiration from neurological diseases

Journal of Neurodevelopmental Disorders, Год журнала: 2022, Номер 14(1)

Опубликована: Май 2, 2022

Intellectual and Developmental Disabilities (IDDs), such as Down syndrome, Fragile X Rett autism spectrum disorder, usually manifest at birth or early childhood. IDDs are characterized by significant impairment in intellectual adaptive functioning, both genetic environmental factors underpin IDD biology. Molecular stratification of remain challenging mainly due to overlapping comorbidity. Advances high throughput sequencing, imaging, tools record behavioral data scale have greatly enhanced our understanding the molecular, cellular, structural, basis some IDDs. Fueled "big data" revolution, artificial intelligence (AI) machine learning (ML) technologies brought a whole new paradigm shift computational Evidently, ML-driven approach clinical diagnoses has potential augment classical methods that use symptoms external observations, hoping push personalized treatment plan forward. Therefore, integrative analyses applications ML technology direct bearing on discoveries The application can potentially improve screening diagnosis, advance complexity comorbidity, accelerate identification biomarkers for research drug development. For more than five decades, IDDRC network supported nexus investigators centers across USA, all striving understand interplay between various underlying In this review, we introduced fast-increasing multi-modal types, highlighted example studies employed illuminate biological mechanisms IDDs, well recent advances their other neurological diseases. We discussed clinical, collection modes, including genetic, phenotypical, along with multiple repositories store share data. Furthermore, outlined fundamental concepts algorithms presented opinion specific gaps will need be filled accomplish, example, reliable implementation ML-based diagnosis clinics. anticipate review guide researchers formulate AI approaches investigate related conditions.

Язык: Английский

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Functional and microstructural plasticity following social and interoceptive mental training

eLife, Год журнала: 2023, Номер 12

Опубликована: Июль 7, 2023

The human brain supports social cognitive functions, including Theory of Mind, empathy, and compassion, through its intrinsic hierarchical organization. However, it remains unclear how the learning refinement skills shapes function structure. We studied if different types mental training induce changes in cortical microstructure, investigating 332 healthy adults (197 women, 20–55 years) with repeated multimodal neuroimaging behavioral testing. Our approach examined longitudinal functional gradients myelin-sensitive T1 relaxometry, two complementary measures observed marked which varied as a content. In particular, microstructure changed result attention-mindfulness socio-cognitive regions functionally associated attention interoception, insular parietal cortices. Conversely, socio-affective resulted differential microstructural classically implicated interoceptive emotional processing, orbitofrontal areas, but did not reorganization. Notably, predicted change attention, compassion perspective-taking. work demonstrates plasticity after social-interoceptive illustrates bidirectional relationship between organisation skills.

Язык: Английский

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Whole-brain structural connectome asymmetry in autism

NeuroImage, Год журнала: 2024, Номер 288, С. 120534 - 120534

Опубликована: Фев. 8, 2024

Autism spectrum disorder is a common neurodevelopmental condition that manifests as disruption in sensory and social skills. Although it has been shown the brain morphology of individuals with autism asymmetric, how this differentially affects structural connectome organization each hemisphere remains under-investigated. We studied whole-brain connectivity-based asymmetry using diffusion magnetic resonance imaging obtained from Brain Imaging Data Exchange initiative. By leveraging dimensionality reduction techniques, we constructed low-dimensional representations connectivity calculated their index. Comparing index between neurotypical controls, found atypical default-mode regions, particularly showing weaker towards right autism. Network communication provided topological underpinnings by demonstrating inferior temporal cortex limbic frontoparietal regions showed reduced global network efficiency decreased send-receive navigation lateral visual cortices Finally, supervised machine learning revealed could be used measure for predicting communication-related autistic symptoms nonverbal intelligence. Our findings provide insights into macroscale alterations underpinnings.

Язык: Английский

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Tau follows principal axes of functional and structural brain organization in Alzheimer’s disease

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 12, 2024

Abstract Alzheimer’s disease (AD) is a brain network disorder where pathological proteins accumulate through networks and drive cognitive decline. Yet, the role of connectivity in facilitating this accumulation remains unclear. Using in-vivo multimodal imaging, we show that distribution tau reactive microglia humans follows spatial patterns variation, so-called gradients organization. Notably, less distinct (“gradient contraction”) are associated with decline regions greater tau, suggesting an interaction between reduced differentiation on cognition. Furthermore, by modeling subject-specific gradient space, demonstrate frontoparietal temporo-occipital cortices baseline within their functionally structurally connected hubs, respectively. Our work unveils for both functional structural organization pathology AD, supports space as promising tool to map progression.

Язык: Английский

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Morphometric brain organization across the human lifespan reveals increased dispersion linked to cognitive performance

PLoS Biology, Год журнала: 2024, Номер 22(6), С. e3002647 - e3002647

Опубликована: Июнь 20, 2024

The human brain is organized as segregation and integration units follows complex developmental trajectories throughout life. cortical manifold provides a new means of studying the brain’s organization in multidimensional connectivity gradient space. However, how morphometric changes across lifespan remains unclear. Here, leveraging structural magnetic resonance imaging scans from 1,790 healthy individuals aged 8 to 89 years, we investigated age-related global, within- between-network dispersions reveal networks 3D manifolds based on similarity network (MSN), combining multiple features conceptualized “fingerprint” an individual’s brain. Developmental global dispersion unfolded along patterns molecular organization, such acetylcholine receptor. Communities were increasingly dispersed with age, reflecting more disassortative profiles within community. Increasing within-network primary motor association cortices mediated influence age cognitive flexibility executive functions. We also found that secondary sensory decreasingly rest during aging, possibly indicating shift extreme central position manifolds. Together, our results MSN perspective space, providing insights into brain, well performance.

Язык: Английский

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The multiscale brain structural re-organization that occurs from childhood to adolescence correlates with cortical morphology maturation and functional specialization

PLoS Biology, Год журнала: 2025, Номер 23(4), С. e3002710 - e3002710

Опубликована: Апрель 1, 2025

From childhood to adolescence, the structural organization of human brain undergoes dynamic and regionally heterogeneous changes across multiple scales, from synapses macroscale white matter pathways. However, during this period, developmental process multiscale architecture, its association with cortical morphological changes, role in maturation functional remain largely unknown. Here, using two independent multimodal imaging datasets aged 6–14 years, we investigated by constructing an vivo connectome model incorporating tractography, cortico–cortical proximity, microstructural similarity. By employing gradient mapping method, principal derived effectively recapitulated sensory-association axis. Our findings revealed a continuous expansion space development, characterized enhanced differentiation between primary sensory higher-order transmodal regions along gradient. This age-related paralleled morphology. Furthermore, coupling connectivity were correlated specialization refinement, as evidenced participation coefficient. Notably, was associated improved cognitive abilities, such working memory attention performance, potentially underpinned synaptic hormone-related biological processes. These advance our understanding intricate implications for performance.

Язык: Английский

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Inter-individual body mass variations relate to fractionated functional brain hierarchies

Communications Biology, Год журнала: 2021, Номер 4(1)

Опубликована: Июнь 14, 2021

Abstract Variations in body mass index (BMI) have been suggested to relate atypical brain organization, yet connectome-level substrates of BMI and their neurobiological underpinnings remain unclear. Studying 325 healthy young adults, we examined associations between functional connectivity inter-individual variations. We utilized non-linear connectome manifold learning techniques represent macroscale organization along continuous hierarchical axes that dissociate low level higher order systems. observed an increased differentiation unimodal heteromodal association networks individuals with BMI, indicative a disrupted modular architecture hierarchy the brain. Transcriptomic decoding gene enrichment analyses identified genes previously implicated genome-wide specific cortical, striatal, cerebellar cell types. These findings illustrate variations adults point potential molecular associations.

Язык: Английский

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