The
hippocampus
is
a
central
modulator
of
the
HPA-axis,
impacting
regulation
stress
on
brain
structure,
function,
and
behavior.
current
study
assessed
whether
three
different
types
3
months
mental
Training
Modules
geared
towards
nurturing
(a)
attention-based
mindfulness,
(b)
socio-affective,
or
(c)
socio-cognitive
skills
may
impact
hippocampal
organization
by
reducing
stress.
We
evaluated
training-induced
changes
in
subfield
volume
intrinsic
functional
connectivity,
combining
longitudinal
structural
resting-state
fMRI
connectivity
analysis
332
healthy
adults.
related
these
to
diurnal
chronic
cortisol
levels.
observed
increases
bilateral
cornu
ammonis
(CA1-3)
following
compassion-based
module
targeting
socio-affective
(
Affect
module),
as
compared
Perspective
module)
waitlist
cohort
with
no
training
intervention.
Structural
were
paralleled
relative
CA1-3
when
fostering
skills.
Furthermore,
structure
function
consistently
correlated
reductions
output.
Notably,
using
multivariate
approach,
we
found
that
other
subfields
did
not
show
group-level
also
contributed
Overall,
provide
link
between
socio-emotional
behavioural
intervention,
The
psychological
structural
model
of
major
depressive
disorder
(MDD)
is
complex
and
multifaceted,
consisting
the
environment
factors
(EF),
cognitive
function
(CF),
behavioral-emotional
manifestations
(BEM).
Currently,
diagnosis
treatment
MDD
difficult
to
improve
disease
state
as
a
whole
through
an
intervention
point.
Constructing
finding
critical
node
are
meaningful
for
MDD.
308
patients
(MDDs)
participated
in
this
research.
They
completed
assessments
34
factors,
including
EF,
CF,
BEM
interoception
(IF).
Pearson
correlation
was
used
investigate
relationship
between
IF
each
factor
multidimensional
(EF,
CF
BEM)
which
constructed
by
equation
modeling
(SEM).
Critical
nodes
were
identified
goodness
fit
model.
created
SEM.
added
further
verify
pathways
effects
network.
significantly
correlated
with
all
factors.
In
model,
EF
(βdirect
=
0.163,
p
0.033)
0.230,
0.003)
can
directly
influence
When
adding
predicted
poorer
led
lower
-
0.346,
<
0.001).
Interoception
dysfunction
increased
risk
-0.525,
0.002)
0.250,
0.031)
patients.
had
largest
total
effect
on
0.365,
βindirect
0.150,
βtotal
0.515),
0.309,
0.126,
0.434)
second
only
EF.
part
that
predicts
BEM.
It
could
be
potential
point
whole.
PLoS Biology,
Год журнала:
2024,
Номер
22(6), С. e3002647 - e3002647
Опубликована: Июнь 20, 2024
The
human
brain
is
organized
as
segregation
and
integration
units
follows
complex
developmental
trajectories
throughout
life.
cortical
manifold
provides
a
new
means
of
studying
the
brain’s
organization
in
multidimensional
connectivity
gradient
space.
However,
how
morphometric
changes
across
lifespan
remains
unclear.
Here,
leveraging
structural
magnetic
resonance
imaging
scans
from
1,790
healthy
individuals
aged
8
to
89
years,
we
investigated
age-related
global,
within-
between-network
dispersions
reveal
networks
3D
manifolds
based
on
similarity
network
(MSN),
combining
multiple
features
conceptualized
“fingerprint”
an
individual’s
brain.
Developmental
global
dispersion
unfolded
along
patterns
molecular
organization,
such
acetylcholine
receptor.
Communities
were
increasingly
dispersed
with
age,
reflecting
more
disassortative
profiles
within
community.
Increasing
within-network
primary
motor
association
cortices
mediated
influence
age
cognitive
flexibility
executive
functions.
We
also
found
that
secondary
sensory
decreasingly
rest
during
aging,
possibly
indicating
shift
extreme
central
position
manifolds.
Together,
our
results
MSN
perspective
space,
providing
insights
into
brain,
well
performance.
Biological Psychiatry Global Open Science,
Год журнала:
2024,
Номер
4(6), С. 100372 - 100372
Опубликована: Авг. 9, 2024
Short
mindfulness-based
interventions
have
gained
traction
in
research
due
to
their
positive
impact
on
well-being,
cognition,
and
clinical
symptoms
across
various
settings.
However,
these
short-term
trainings
are
viewed
as
preliminary
steps
within
a
more
extensive
transformative
path,
presumably
leading
long-lasting
trait
changes.
Despite
this,
little
is
still
known
about
the
brain
correlates
of
meditation
traits.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июль 29, 2024
Abstract
Adolescence
is
a
period
of
dynamic
brain
remodeling
and
susceptibility
to
psychiatric
risk
factors,
mediated
by
the
protracted
consolidation
association
cortices.
Here,
we
investigated
whether
longitudinal
variation
in
adolescents’
resilience
psychosocial
stressors
during
this
vulnerable
associated
with
ongoing
myeloarchitectural
maturation
functional
networks.
We
used
repeated
myelin-sensitive
Magnetic
Transfer
(MT)
resting-state
neuroimaging
(
n
=
141),
captured
adversity
exposure
adverse
life
events,
dysfunctional
family
settings,
socio-economic
status
at
two
timepoints,
one
years
apart.
Development
toward
more
resilient
functioning
was
increasing
myelination
anterolateral
prefrontal
cortex,
which
showed
stabilized
connectivity.
Studying
depth-specific
intracortical
MT
profiles
cortex-wide
synchronization
maturation,
further
observed
wide-spread
reconfiguration
cortices
paralleled
attenuated
reorganization
increasingly
outcomes.
Together,
resilient/susceptible
considerable
intra-individual
change
multi-modal
cortical
refinement
processes
local
system-level.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Авг. 23, 2024
Abstract
Determining
sex-bias
in
brain
structure
is
of
great
societal
interest
to
improve
diagnostics
and
treatment
brain-related
disorders.
So
far,
studies
on
predominantly
focus
macro-scale
measures,
often
ignore
factors
determining
this
bias.
Here
we
study
cortical
hippocampal
microstructure
relation
sex
hormones.
Investigating
quantitative
intracortical
profiling
in-vivo
using
the
T1w/T2w
ratio
1093
healthy
females
males
cross-sectional
Human
Connectome
Project
young
adult
sample,
find
that
regional
differs
between
effect
size
varies
depending
self-reported
hormonal
status
females.
Microstructural
expression
hormone
genes,
based
an
independent
post-mortem
are
spatially
coupled.
Lastly,
most
pronounced
paralimbic
areas,
with
low
laminar
complexity,
which
predicted
be
plastic
their
cytoarchitectural
properties.
Albeit
correlative,
our
underscores
importance
incorporating
variables
into
investigation
plasticity.
Adolescence
is
a
period
of
dynamic
brain
remodeling
and
susceptibility
to
psychiatric
risk
factors,
mediated
by
the
protracted
consolidation
association
cortices.
Here,
we
investigated
whether
intra-individual
trajectories
psychosocial
functioning
relative
environmental
stressor
exposure
-
including
adverse
life
events,
dysfunctional
family
settings,
socio-economic
status
are
tied
myeloarchitectural
maturation
down-stream
effects
on
intrinsic
function.
To
this
end,
employed
longitudinal
myelin-sensitive
Magnetic
Transfer
(MT)
resting-state
imaging
in
NSPN
cohort
(aged
14-26y).
Developing
towards
more
resilient
was
linked
increasing
myelination
anterolateral
prefrontal
cortex,
which
exhibited
stabilized
functional
connectivity.
Studying
depth-specific
intracortical
MT
profiles
cortex-wide
synchronization
maturation,
further
observed
wide-spread
re-configuration
cortices
paralleled
attenuated
reorganization
with
increasingly
outcomes.
Together,
resilient/susceptible
showed
considerable
change
reflected
multi-modal
cortical
refinement
processes
at
local
system-level.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
The
human
prefrontal
cortex
(PFC)
exhibits
markedly
protracted
developmental
plasticity,
yet
whether
reductions
in
plasticity
occur
synchronously
across
cortical
layers
is
unclear.
Animal
studies
have
shown
that
intracortical
myelin
consolidates
neural
circuits
to
close
periods
of
plasticity.
Here,
we
use
quantitative
imaging
collected
from
youth
(ages
10-32
years)
at
ultra-high
field
(7T)
investigate
deep
and
superficial
PFC
exhibit
different
timeframes
We
find
matures
along
a
deep-to-superficial
axis
the
PFC;
this
maturational
timing
expressed
extent
cytoarchitecturally
distinct
regions
frontal
hierarchy.
By
integrating
mapping
with
electroencephalogram
cognitive
phenotyping,
provide
evidence
dissociably
impact
timescales
activity,
task
learning
rates,
processing
speed.
Heterochronous
maturation
an
underrecognized
mechanism
through
which
association
balances
cognitively-relevant
increases
circuit
stability
efficiency
extended
neuroplasticity.
