International Journal of experimental research and review,
Год журнала:
2024,
Номер
37, С. 149 - 158
Опубликована: Март 30, 2024
In
the
twenty-first
century,
there
have
been
a
number
of
outbreaks,
beginning
with
dengue,
swine
flu,
Nipah,
Ebola,
chikungunya,
and
Zika,
which
were
continuously
outbreaks
in
some
specific
regions.
The
mosquito-transmitted
flavivirus
Japanese
encephalitis
(JE)
virus,
similar
to
dengue
fever
West
Nile
viruses,
negative-single-stranded
Ebola
virus
(EBOV)
are
two
most
emerging
WHO's
most-prioritized
diseases.
Natural
products
always
served
as
an
alternative
mainstream
drugs
emergencies.
Thus,
due
their
excellent
antiviral
activity,
present
study
focused
on
marine
alkaloids
assessed
potency
against
JE
EBOV
viruses.
Using
various
bioinformatics
tools,
we
selected
60
different
for
anti-JE
activity
RNA-dependent
RNA
polymerase
(PDB
ID:
4HDG),
NS3-helicase
2Z83),
NS5-protease
4K6M),
well
anti-EBOV
efficacy
targeting
nucleoprotein
4Z9P),
viral
protein
24
4M0Q),
40
3TCQ).
Based
previous
records
combined
molecular
docking
scores,
physicochemical,
toxicity,
pharmacokinetic,
drug-ability
profiles,
researchers
concluded
that
manzamines
A,
F,
X
6-deoxymanzamine
8-hydroxymanzamine
may
be
best
among
all
candidates
EV
infection
control.
summary,
exhibit
need
explored
more
bioactive
drug
discovery,
where
tools
cost-effective,
resource-efficient,
time-saving
platform
than
traditional
discovery
modules
locate
lead
used
medicine
health
conditions.
PeerJ,
Год журнала:
2023,
Номер
11, С. e15990 - e15990
Опубликована: Сен. 7, 2023
Scientists
have
made
great
efforts
to
understand
the
evolution
of
SARS-CoV-2
(Severe
Acute
Respiratory
Syndrome
Coronavirus
2)
provide
crucial
information
public
health
experts
on
strategies
control
this
viral
pathogen.
The
pandemic
coronavirus
disease
that
began
in
2019,
COVID-19,
lasted
nearly
three
years,
and
all
countries
set
different
epidemic
prevention
policies
for
virus.
continuous
alters
its
pathogenicity
infectivity
human
hosts,
thus
policy
treatments
been
continually
adjusted.
Based
our
previous
study
dynamics
binding
ability
prediction
between
COVID-19
spike
protein
ACE2,
present
mined
over
10
million
sequences
epidemiological
data
during
2020-2022
evolutionary
path
SARS-CoV-2.
We
analyzed
predicted
mutation
rates
whole
genome
main
proteins
from
populations
adaptive
relationship
humans
COVID-19.
Our
identified
a
correlation
each
various
populations.
Overall,
analysis
provides
scientific
basis
developing
data-driven
confront
pathogens.
Mutations
in
regulatory
mechanisms
that
control
gene
expression
contribute
to
phenotypic
diversity
and
thus
facilitate
the
adaptation
of
microbes
other
organisms
new
niches.
Comparative
genomics
can
be
used
infer
rewiring
architecture
based
on
large
effect
mutations
like
loss
or
acquisition
transcription
factors
but
may
insufficient
identify
small
changes
noncoding,
intergenic
DNA
sequence
elements
drive
divergence.
In
human-derived
Vibrio
cholerae,
response
distinct
chemical
cues
triggers
production
multiple
regulate
type
VI
secretion
system
(T6),
a
broadly
distributed
weapon
for
interbacterial
competition.
However,
date,
signaling
network
remains
poorly
understood
because
no
element
has
been
identified
major
T6
locus.
Here
we
conserved
Abstract
Background
Bats
harbor
various
viruses
without
severe
symptoms
and
act
as
their
natural
reservoirs.
The
tolerance
of
bats
against
viral
infections
is
assumed
to
originate
from
the
uniqueness
immune
system.
However,
how
responses
vary
between
primates
remains
unclear.
Here,
we
characterized
differences
in
by
peripheral
blood
mononuclear
cells
pathogenic
stimuli
(humans,
chimpanzees,
macaques)
(Egyptian
fruit
bats)
using
single-cell
RNA
sequencing.
Results
We
show
that
induction
patterns
key
cytosolic
DNA/RNA
sensors
antiviral
genes
differed
bats.
A
novel
subset
monocytes
induced
specifically
was
identified.
Furthermore,
robustly
respond
DNA
virus
infection
even
though
major
are
dampened
Conclusions
Overall,
our
data
suggest
substantially
different
bats,
presumably
underlying
difference
pathogenicity
among
mammalian
species
tested.
International Journal of experimental research and review,
Год журнала:
2024,
Номер
37, С. 149 - 158
Опубликована: Март 30, 2024
In
the
twenty-first
century,
there
have
been
a
number
of
outbreaks,
beginning
with
dengue,
swine
flu,
Nipah,
Ebola,
chikungunya,
and
Zika,
which
were
continuously
outbreaks
in
some
specific
regions.
The
mosquito-transmitted
flavivirus
Japanese
encephalitis
(JE)
virus,
similar
to
dengue
fever
West
Nile
viruses,
negative-single-stranded
Ebola
virus
(EBOV)
are
two
most
emerging
WHO's
most-prioritized
diseases.
Natural
products
always
served
as
an
alternative
mainstream
drugs
emergencies.
Thus,
due
their
excellent
antiviral
activity,
present
study
focused
on
marine
alkaloids
assessed
potency
against
JE
EBOV
viruses.
Using
various
bioinformatics
tools,
we
selected
60
different
for
anti-JE
activity
RNA-dependent
RNA
polymerase
(PDB
ID:
4HDG),
NS3-helicase
2Z83),
NS5-protease
4K6M),
well
anti-EBOV
efficacy
targeting
nucleoprotein
4Z9P),
viral
protein
24
4M0Q),
40
3TCQ).
Based
previous
records
combined
molecular
docking
scores,
physicochemical,
toxicity,
pharmacokinetic,
drug-ability
profiles,
researchers
concluded
that
manzamines
A,
F,
X
6-deoxymanzamine
8-hydroxymanzamine
may
be
best
among
all
candidates
EV
infection
control.
summary,
exhibit
need
explored
more
bioactive
drug
discovery,
where
tools
cost-effective,
resource-efficient,
time-saving
platform
than
traditional
discovery
modules
locate
lead
used
medicine
health
conditions.
