The impact of the human thalamus on brain-wide information processing

Nature reviews. Neuroscience, Год журнала: 2023, Номер 24(7), С. 416 - 430

Опубликована: Май 26, 2023

Язык: Английский

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The mediodorsal thalamus in executive control

Neuron, Год журнала: 2024, Номер 112(6), С. 893 - 908

Опубликована: Янв. 30, 2024

Язык: Английский

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Neuropsychological evidence of multi-domain network hubs in the human thalamus

eLife, Год журнала: 2021, Номер 10

Опубликована: Окт. 6, 2021

Hubs in the human brain support behaviors that arise from network interactions. Previous studies have identified hub regions thalamus are connected with multiple functional networks. However, behavioral significance of thalamic hubs has yet to be established. Our framework predicts subregions strong properties broadly involved functions across cognitive domains. To test this prediction, we studied patients focal lesions conjunction analyses thalamocortical connectome. In our stronger were associated widespread deficits executive, language, and memory functions, whereas weaker more limited deficits. These results highlight how a large-scale model can broaden understanding function for cognition.

Язык: Английский

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Time to retire the serial Papez circuit: Implications for space, memory, and attention

Neuroscience & Biobehavioral Reviews, Год журнала: 2022, Номер 140, С. 104813 - 104813

Опубликована: Авг. 5, 2022

After more than 80 years, Papez serial circuit remains a hugely influential concept, initially for emotion, but in recent decades, memory. Here, we show how this is anatomically and mechanistically naïve as well outdated. We argue that new conceptualisation necessitated by anatomical functional findings emphasize the equal, working partnerships between anterior thalamic nuclei hippocampal formation, along with their neocortical interactions supporting, episodic Furthermore, despite importance of mnemonic processing, there growing evidence these support multiple aspects cognition, only some which are directly associated function. By viewing multifunctional hub, clearer picture emerges extra-hippocampal regions supporting The reformulation presented here underlines need to retire serially processing circuit.

Язык: Английский

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Thalamocortical contributions to cognitive task activity

eLife, Год журнала: 2022, Номер 11

Опубликована: Дек. 20, 2022

Thalamocortical interaction is a ubiquitous functional motif in the mammalian brain. Previously (Hwang et al., 2021), we reported that lesions to network hubs human thalamus are associated with multi-domain behavioral impairments language, memory, and executive functions. Here, show how task-evoked thalamic activity organized support these broad cognitive abilities. We analyzed magnetic resonance imaging (MRI) data from subjects performed 127 tasks encompassing range of representations. first investigated spatial organization found basis set patterns evoked processing needs each task. Specifically, anterior, medial, posterior-medial exhibit hub-like profiles suggestive participation. These task overlapped interlinking cortical systems. To further determine relevance thalamocortical connectivity, built data-driven model test whether can be used predict activity. The predicted task-specific patterns, outperformed comparison models on cortical, hippocampal, striatal regions. Simulated low-dimensional, multi-task hub regions impaired prediction. This simulation result was supported by neuropsychological patients focal lesions. In summary, our results suggest general organizational principle system supports

Язык: Английский

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Thalamocortical architectures for flexible cognition and efficient learning

Trends in Cognitive Sciences, Год журнала: 2024, Номер 28(8), С. 739 - 756

Опубликована: Июнь 17, 2024

The brain exhibits a remarkable ability to learn and execute context-appropriate behaviors. How it achieves such flexibility, without sacrificing learning efficiency, is an important open question. Neuroscience, psychology, engineering suggest that reusing repurposing computations are part of the answer. Here, we review evidence thalamocortical architectures may have evolved facilitate these objectives flexibility efficiency by coordinating distributed computations. Recent work suggests prefrontal cortical networks compute with flexible codes, mediodorsal thalamus provides regularization promote efficient reuse. Thalamocortical interactions resemble hierarchical Bayesian computations, their network implementation can be related existing gating, synchronization, hub theories thalamic function. By reviewing recent findings providing novel synthesis, highlight key research horizons integrating computation, cognition, systems neuroscience.

Язык: Английский

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Factors behind poor cognitive outcome following a thalamic stroke

Journal of Neurology, Год журнала: 2025, Номер 272(1)

Опубликована: Янв. 1, 2025

Abstract Background Thalamic strokes produce neurological, cognitive, and behavioral symptoms depending on the thalamic nuclei involved. While traditionally associated with severe cognitive deficits, recent studies suggest more modest impairments. This study aims to identify factors that influence severity of impairment following stroke. Methods We recruited 40 patients (mean age 51.1) chronic isolated stroke 45 healthy subjects 48.5) who underwent neuroimaging neuropsychological assessment. Cluster principal component analyses were used discriminate from based tasks. Disconnectome maps cortical thickness analyzed understand distant impact strokes. Results Two profiles emerged cluster analysis. 1 included mostly ( n = 43) no or minor deficits 20). 2 19) two in verbal memory, executive functions, attention. encompassed all right stroke, while bilateral mammillothalamic tract interruption. Patients left-sided equally divided between clusters. Significant differences clusters age, education, interthalamic adhesion disruption, lesion volume, location. had lateral lesions greater disruption anterior projection. Conclusions Contrary common expectations, our findings many have relatively good outcomes. In contrast, we identified behind poor outcomes will help clinicians.

Язык: Английский

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Therapeutic Potential and Limitation of Serotonin Type 7 Receptor Modulation

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2070 - 2070

Опубликована: Янв. 20, 2023

Although a number of mood-stabilising atypical antipsychotics and antidepressants modulate serotonin type 7 receptor (5-HT7), the detailed contributions 5-HT7 function to clinical efficacy pathophysiology have not been fully understood. The antipsychotic agent, lurasidone, partial agonist reuptake inhibitor, vortioxetine, exhibit higher binding affinity than other conventional antidepressants. To date, initially expected rapid onset antidepressant effects-in comparison with or antipsychotics-due inhibition has observed lurasidone vortioxetine; however, several studies suggest that likely contributes quality life patients schizophrenia mood disorders via improvement cognition. Furthermore, recent preclinical reported might mitigate antipsychotic-induced weight gain metabolic complication by blocking monoamine receptors. Further for development modulation against neurodevelopmental neurodegenerative diseases ongoing. various findings from indicate possibility modifications can provide two independent strategies. first is ameliorates dysfunction inter-neuronal transmission in mature networks. activation improve due microstructure abnormality neurotransmission network-which could be unaffected therapeutic agents-via modulating intracellular signalling during stage loss neural networks aging. This review attempts describe current novel applications based on findings.

Язык: Английский

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Triple Interactions Between the Environment, Brain, and Behavior in Children: An ABCD Study

Biological Psychiatry, Год журнала: 2023, Номер 95(9), С. 828 - 838

Опубликована: Дек. 25, 2023

Язык: Английский

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Thalamic contributions to psychosis susceptibility: Evidence from co‐activation patterns accounting for intra‐seed spatial variability (μCAPs)

Human Brain Mapping, Год журнала: 2024, Номер 45(5)

Опубликована: Март 23, 2024

Abstract The temporal variability of the thalamus in functional networks may provide valuable insights into pathophysiology schizophrenia. To address complexity role thalamic nuclei psychosis, we introduced micro‐co‐activation patterns (μCAPs) and employed this method on human genetic model schizophrenia 22q11.2 deletion syndrome (22q11.2DS). Participants underwent resting‐state MRI a data‐driven iterative process resulting identification six whole‐brain μCAPs with specific activity within thalamus. Unlike conventional methods, extract dynamic spatial that reveal partially overlapping non‐mutually exclusive subparts. Thus, detects finer foci initial seed region, retaining clinically relevant information. We found μCAP showing co‐activation mediodorsal brain‐wide cortical regions was expressed significantly less frequently patients 22q11.2DS, its occurrence negatively correlated severity positive psychotic symptoms. Additionally, auditory–visual cortex their respective geniculate two different μCAPs. One these co‐activated salience areas, while other default mode network (DMN). A significant shift from salience+visuo‐auditory‐thalamus to DMN + visuo‐auditory‐thalamus observed 22q11.2DS. our findings support existing research gatekeeping for sensory information psychosis revisit evidence hyperconnectivity audio‐visual 22q11.2DS context connectivity, seen here as hyper‐occurrence circuits task‐negative brain networks.

Язык: Английский

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