Acute alcohol and chronic drinking bidirectionally regulate the excitability of prefrontal cortex vasoactive intestinal peptide interneurons DOI Creative Commons
Shannon M. Thompson, Anthony S. Ferranti, Max E. Joffe

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Март 10, 2023

The prefrontal cortex (PFC) regulates drinking behaviors and affective changes following chronic alcohol use. PFC activity is dynamically modulated by local inhibitory interneurons (INs), which can be divided into non-overlapping groups with distinct functional roles. Within deeper layers of neocortex, INs that express either parvalbumin or somatostatin directly inhibit pyramidal cells. By contrast, the plurality all remaining vasoactive intestinal peptide (VIP), reside within superficial layers, preferentially target other types INs. While recent studies have described adaptations to parvalbumin-INs somatostatin-INs in use models, whether ethanol affect physiology VIP-INs has not been reported. To address this gap, we used genetically engineered female male mice 1-3 prelimbic for whole-cell patch-clamp electrophysiology. We found (20 mM, ∼0.09 BEC) application brain slices enhances VIP-IN excitability. next examined effects providing 4 weeks intermittent access (IA) two-bottle choice home cage. In these studies, from IA displayed reduced excitability relative cells water-only controls. Finally, assessed continue abstinence. After 7-11 days without ethanol, hypo-excitability persisted, whereas were different their Together, findings illustrate acute suggest undergo pronounced homeostatic long-term drinking.

Язык: Английский

Transient enhancement of stimulus-evoked activity in neocortex during sensory learning DOI Open Access
Mo Zhu, Sandra J. Kuhlman, Alison L. Barth

и другие.

Learning & Memory, Год журнала: 2024, Номер 31(6), С. a053870 - a053870

Опубликована: Июнь 1, 2024

Synaptic potentiation has been linked to learning in sensory cortex, but the connection between this and increased sensory-evoked neural activity is not clear. Here, we used longitudinal vivo Ca 2+ imaging barrel cortex of awake mice test hypothesis that excitatory synaptic strength during a whisker-dependent sensory-association task would be correlated with enhanced stimulus-evoked firing. To isolate responses from dynamic, task-related activity, was performed outside training context. Although prior studies indicate multiwhisker stimuli drive robust subthreshold observed sparse activation L2/3 pyramidal (Pyr) neurons both control trained mice. Despite evidence for strengthening at thalamocortical intracortical synapses brain area onset learning—indeed, under our conditions axons were robustly activated—we Pyr somatosensory (barrel) displayed only modest increases concentrated training. Activity renormalized over longer periods. In contrast, when rewards uncoupled pseudotraining paradigm, significantly suppressed. These findings stimulation without coupled may briefly enhance phenomenon might help link input behavioral outcomes learning.

Язык: Английский

Процитировано

3
Unraveling the dynamical mechanisms of motor preparation based on the heterogeneous attractor model DOI
Xiaomeng Wang,

Lining Yin,

Yu Ying

и другие.

Chaos Solitons & Fractals, Год журнала: 2025, Номер 194, С. 116220 - 116220

Опубликована: Фев. 28, 2025

Язык: Английский

Процитировано

0
Distinct Roles of Somatostatin and Parvalbumin Interneurons in Regulating Predictive Actions and Emotional Responses During Trace Eyeblink Conditioning DOI Creative Commons
Jiaman Dai, Qian‐Quan Sun

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Learning involves evaluating multiple dimensions of information and generating appropriate actions, yet how the brain assigns value to this remains unclear. In study, we show that two types interneurons (INs) in primary somatosensory cortex-somatostatin-expressing (SST-INs) parvalbumin-expressing (PV-INs) neurons-differentially contribute evaluation during trace eyeblink conditioning (TEC). An air puff (unconditioned stimulus, US) delivered after a whisker stimulus (conditioned CS) elicited both reflexive eye closure stress-related locomotion. However, only self-initiated, anticipatory CS window, measured via electromyography (EMG), was directly relevant learning performance. We found SST-IN activity changes aligned with induced blinks period, correlated EMG across learning. contrast, PV-IN positively locomotion following US showed no related changes, suggesting role processing emotional or aversive component task. Furthermore, cholinergic signaling nicotinic receptors modulated SST- activities, manner consistent their distinctive roles, linking these regulation learning-related actions responses, respectively. These findings demonstrate distinct interneuron populations evaluate different information-SST-INs for predictive, adaptive PV-INs responses-to guide behavior.

Язык: Английский

Процитировано

0
Reliable sensory processing of superficial cortical interneurons is modulated by behavioral state DOI Creative Commons
Carolyn G. Sweeney, Maryse E. Thomas, Christine Liu

и другие.

Cell Reports, Год журнала: 2025, Номер 44(5), С. 115678 - 115678

Опубликована: Май 1, 2025

GABAergic interneurons in cortical layer 1 (L1) integrate sensory and top-down inputs to modulate network activity support learning-related plasticity. However, little is known about how drive L1 interneuron activity. We used two-photon calcium imaging measure sound-evoked responses two populations expressing vasoactive intestinal peptide (VIP) or neuron-derived neurotrophic factor (NDNF) mouse auditory cortex. found that respond both simple complex sounds, but their are highly variable across trials. Despite this variability, these reliably a narrow range of stimuli, reflecting selectivity for specific spectrotemporal sound features. Response reliability was modulated by behavioral state predicted the neighboring interneurons. These findings reveal exhibit tuning identify modulation response as potential mechanism which relays state-dependent cues shape representations.

Язык: Английский

Процитировано

0
Robust multisensory deviance detection in the mouse parietal associative area DOI Creative Commons
Alice B. Van Derveer, Jordan M. Ross, Jordan P. Hamm

и другие.

Current Biology, Год журнала: 2023, Номер 33(18), С. 3969 - 3976.e4

Опубликована: Авг. 28, 2023

Язык: Английский

Процитировано

8
Top-down modulation of visual cortical stimulus encoding and gamma independent of firing rates DOI Creative Commons
Chris Lewis, Thomas Wunderle, Pascal Fries

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 12, 2024

Neurons in primary visual cortex integrate sensory input with signals reflecting the animal's internal state to support flexible behavior. Internal variables, such as expectation, attention, or current goals, are imposed a top-down manner via extensive feedback projections from higher-order areas. We optogenetically activated high-order area, area 21a, lightly anesthetized cat (OptoTD), while recording neuronal populations V1. OptoTD induced strong, up several fold, changes gamma-band synchronization together much smaller firing rate, and two effects showed no correlation. specificity for features of simultaneously presented stimuli. OptoTD-induced gamma synchronization, but not rates, were predictive simultaneous amount encoded stimulus information. Our findings suggest that one important role is modulate information by neurons.

Язык: Английский

Процитировано

2
(outdated draft) Somatostatin and the pathophysiology of Alzheimer’s disease DOI Creative Commons
Victor N. Almeida

Опубликована: Апрель 14, 2024

Since early research on Alzheimer’s disease (AD), it has been known that among the central features of its progression are altered levels neuropeptide somatostatin, and colocalisation somatostatin-positive interneurons (SST-INs) with amyloid-β plaques, leading to cell death. In this theoretical review, I propose a model for pathogenesis AD coheres qualitative profile neuropsychological deficits neurobiological progression. Namely, hypofunctional hyperactive SST-INs struggle control hyperactivity in mid-temporal regions stages, excessive presynaptic GABA-B inhibition, GABA-B1a-APP complex downregulation internalisation, thereby boosting Aβ production. Concomitantly, SST-14 release accumulates near form amyloids, bind toxic mixed oligomers. This leads differential SST-IN death through excitotoxicity, further disinhibition, SST deficits, increased release, fibrillation plaque formation. networks distributions tightly overlap brain. Finally, disinhibition reportedly induces qualitatively agree those found cohorts, pattern separation encoding mnemonic indiscrimination, interference reconsolidation.

Язык: Английский

Процитировано

1
Moculus: an immersive virtual reality system for mice incorporating stereo vision DOI Creative Commons

Linda Judák,

Gergely Dobos,

Katalin Ócsai

и другие.

Nature Methods, Год журнала: 2024, Номер unknown

Опубликована: Дек. 12, 2024

Abstract Due to technical roadblocks, it is unclear how visual circuits represent multiple features or behaviorally relevant representations are selected for long-term memory. Here we developed Moculus, a head-mounted virtual reality platform mice that covers the entire field, and allows binocular depth perception full immersion. This controllable environment, with three-dimensional (3D) corridors 3D objects, in combination acousto-optical imaging, affords rapid learning uncovering of circuit substrates one measurement session. Both control reinforcement-associated cue coding neuronal assemblies transiently expanded by reinforcement feedback near-saturation levels. increases computational capability competition among encode information. The form partially orthogonal overlapping clusters centered around hub cells higher earlier ramp-like responses, as well locally increased functional connectivity.

Язык: Английский

Процитировано

1
Glucagon Increases Retinal Rod Bipolar Cell Inhibition Through a D1 Dopamine Receptor-Dependent Pathway That Is Altered After Lens-Defocus Treatment in Mice DOI Creative Commons
Felipe Tapia,

Valentín Peñaloza,

Francisco Silva-Olivares

и другие.

Investigative Ophthalmology & Visual Science, Год журнала: 2024, Номер 65(1), С. 46 - 46

Опубликована: Янв. 30, 2024

Purpose: Members of the secretin/glucagon family have diverse roles in retinal physiological and pathological conditions. Out them, glucagon has been associated with eye growth regulation image defocus signaling eye, both processes central myopia induction. On other hand, dopamine is perhaps most studied molecule proposed as fundamental pathogenesis. However, glucagonergic activity mammalian retina its possible link dopaminergic remain unknown. Methods: To corroborate whether participate together modulation synaptic retina, inhibitory post-synaptic currents were measured rod bipolar cells from slices wild type negative lens-exposed mice, using whole cell patch-clamp recordings selective pharmacology. Results: Glucagon produced an increase current frequency cells, which was also dependent on activity, it abolished by 1 receptor antagonism under scotopic The effect after 3-week lens-exposure but could be recovered agonism. Conclusions: Altogether, these results support a neuromodulatory role mammals part activity-dependent pathway that affected myopia-inducing

Язык: Английский

Процитировано

1
Stimulus-specific enhancement in mouse visual cortex requires GABA but not VIP-peptide release from VIP interneurons DOI
Megumi Kaneko, Mahmood S. Hoseini, James A. Waschek

и другие.

Journal of Neurophysiology, Год журнала: 2024, Номер 132(1), С. 34 - 44

Опубликована: Май 22, 2024

Many neurons package and release a peptide along with conventional neurotransmitter. The view is that such peptides exert late, slow effects on plasticity. We studied form of cortical plasticity depends the activity express both vasoactive intestinal (VIP) inhibitory neurotransmitter GABA. GABA accounted for their action plasticity, no effect deleting this phenomenon.

Язык: Английский

Процитировано

1