Diabetes Research and Clinical Practice, Год журнала: 2023, Номер 198, С. 110626 - 110626
Опубликована: Март 16, 2023
Язык: Английский
Journal of Obesity & Metabolic Syndrome, Год журнала: 2022, Номер 31(2), С. 169 - 177
Опубликована: Июнь 30, 2022
Ye Seul Yang, Byoung-Duck Han, Kyungdo Jin-Hyung Jung, Jang Won Son; On Behalf of the Taskforce Team Obesity Fact Sheet Korean Society for Study Obesity. J Obes Metab Syndr 2022;31:169-77. https://doi.org/10.7570/jomes22024
Язык: Английский
Процитировано
114
Endocrinology and Metabolism, Год журнала: 2022, Номер 37(1), С. 1 - 8
Опубликована: Фев. 28, 2022
The prevalence of obesity is rapidly increasing worldwide. Obesity should not be understood only as the accumulation fat in body, but instead a phenomenon that exerts different effects on our health according to place deposition and its stability. starting point most metabolic diseases, such diabetes, hypertension, syndrome, sleep apnea, eventually cardiovascular disease. There are kinds obesity, ranging from simple sarcopenic obesity. main purpose intervening address decrease ultimate consequence obesity—namely, mechanism through which especially abdominal increases risk obesity-induced derangement health, leading development diseases non-alcoholic fatty liver disease, initiators vascular damage. In this review, I discuss influence various types how these increase disease risk.
Язык: Английский
Процитировано
42
JACC Asia, Год журнала: 2023, Номер 3(3), С. 491 - 502
Опубликована: Июнь 1, 2023
The number of people with metabolic syndrome (MetS) is increasing worldwide, and many socioeconomic environmental factors contribute to this. authors investigated tangible trends in the prevalence MetS using 2001 2020 versions Korea National Health Nutrition Examination Survey (KNHANES). In these surveys, stratified multistage sampling designs were used approximate entire population. Blood pressure, waist circumference, lifestyle variables examined a standardized fashion. Metabolic biomarkers measured central laboratory operated by Korean government. age-adjusted increased significantly from 27.1% 33.2% 2020. It was more prevalent men (25.8%→40.0%) but did not change women (28.2%→26.2%). Among 5 components, proportions high glucose level large circumference substantially 17.9% 12.2% over 20 years, while high-density lipoprotein cholesterol levels significantly, resulting decrease low 20.4%. Caloric intake derived carbohydrates decreased 68.1% 61.3%, fat consumption 16.7% 23.0%. Notably, sugar-sweetened beverage showed an almost 4-fold increase 2007 2020, physical activity 2014 Glycemic dysregulation abdominal obesity key features contributing observed during past years. Rapid economic socioenvironmental changes this period may be involved phenomenon. Understanding could valuable for other countries undergoing such transformation.
Язык: Английский
Процитировано
25
Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 845 - 858
Опубликована: Март 1, 2024
Anti-obesity medications (AOMs), along with lifestyle interventions, are effective means of inducing and maintaining weight loss in patients obesity. Although the efficacy AOMs has been reported, there have no direct comparisons these drugs. Therefore, present study, we aimed to compare all available Korea a real-world setting.
Язык: Английский
Процитировано
9
Frontiers in Endocrinology, Год журнала: 2022, Номер 12
Опубликована: Янв. 19, 2022
Only few studies have investigated the role of probiotics in development obesity. We aimed to determine efficacy and safety an intake Lactobacillus plantarum K50 (LPK) on body fat lipid profiles people with This randomized, double-blind, placebo-controlled, clinical trial involved 81 adults a mass index 25-30 kg/m2 who were assigned randomly diet including 4 × 109 colony-forming unit LPK or placebo. Changes fat, anthropometric parameters, biomarkers obesity compared using linear mixed-effect model. After 12 weeks treatment, weight, mass, abdominal area did not change significantly two groups. However, total cholesterol levels decreased from 209.4 ± 34.4 mg/dL 203.5 30.9 group, but increased 194.7 37.5 199.9 30.7 placebo group (P = 0.037). Similarly, triglyceride 135.4 115.8 114.5 65.9 significant difference between supplementation also tended decrease leptin It changed distribution gut microbiota significantly, increase L. Actinobacteria, both whose changes abundance correlated visceral adiposity, borderline significance. A 12-week consumption reduced favorable alterations microbiota, suggesting potential benefits for controlling blood profiles.
Язык: Английский
Процитировано
36
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3384 - 3384
Опубликована: Фев. 8, 2023
The brain, particularly the hypothalamus and brainstem, monitors integrates circulating metabolic signals, including gut hormones. Gut–brain communication is also mediated by vagus nerve, which transmits various gut-derived signals. Recent advances in our understanding of molecular gut–brain promote development next-generation anti-obesity medications that can safely achieve substantial lasting weight loss comparable to surgery. Herein, we comprehensively review current knowledge about central regulation energy homeostasis, hormones involved food intake, clinical data on how these have been applied drugs. Insight into axis may provide new therapeutic perspectives for treatment obesity diabetes.
Язык: Английский
Процитировано
22
Journal of Obesity & Metabolic Syndrome, Год журнала: 2023, Номер 32(1), С. 46 - 54
Опубликована: Март 22, 2023
Metabolic/bariatric surgery is currently the most effective measure to treat morbid obesity and obesity-related comorbidities such as type 2 diabetes.It has proven not only in terms of short-term weight loss, but also maintaining lower body for several decades.Such loss improves patient quality life extends expectancy.It crucial patients understand likely results a given bariatric procedure so that they can make an informed decision about whether undergo surgery.The amount after metabolic/bariatric usually important outcome interest considering surgical treatment.It common primary endpoint healthcare providers.Patients undergoing want tangible realistic expectations how much could lose surgery, professionals need determine at each follow-up visit are on track reach their target provide timely intervention with insufficient or regain.Weight influenced by many clinical variables, including initial mass index, age, gender, ethnicity, surgery.A well-validated chronological prediction model would enable patient-centered counseling goal setting.This review summarizes compares publicly available models.
Язык: Английский
Процитировано
19
Journal of Lipid and Atherosclerosis, Год журнала: 2023, Номер 12(2), С. 201 - 201
Опубликована: Янв. 1, 2023
We aimed to investigate the longitudinal trends in prevalence of hypertriglyceridemia Korean adults and hypertriglyceridemia-associated lifestyle habits, socioeconomic factors comorbidities.
Язык: Английский
Процитировано
16
Diabetes & Metabolism Journal, Год журнала: 2022, Номер 46(5), С. 803 - 807
Опубликована: Янв. 11, 2022
We investigated the incidence of diagnosed diabetes in South Korean adults (aged ≥20 years) by analyzing data for National Health Insurance Service-National Sample Cohort. From 2006 to 2015, overall rate decreased approximately 0.1% per year until 2015. Although, this trend was observed individuals aged 40 years or over, increased slightly 20-29 and 30-39 age groups, from 0.5 0.7 2.0 2.6 1,000 individuals, respectively. The proportion obese young with remarkably, 51.4% 72.4% Thus, need early identification weight-control strategies prevent diabetes.
Язык: Английский
Процитировано
20
International Immunopharmacology, Год журнала: 2022, Номер 111, С. 109083 - 109083
Опубликована: Июль 30, 2022
Overnutrition-induced hypothalamic inflammation greatly disturbs feeding behavior and energy homeostasis as well the pathogenesis of obesity. Butyrate, a short-chain fatty acid, reportedly participates in regulation immune response metabolism body. However, role butyrate overnutrition-induced microglial activation remains unclear. In present study, we established high-fat diet (HFD)-induced model mice. Oral supplementation with sodium (NaB) significantly reduced HFD-induced microgliosis, inflammatory cytokine expression, endoplasmic reticulum (ER) stress, neuronal apoptosis, neuropeptide Y (NPY) expression mouse hypothalamus. Utilizing high-glucose (HG)-stimulated vitro, found that NaB inhibited HG-induced factor IL-1β. Moreover, exerted an antioxidant effect by balancing HO-1 NOX4 thus preventing reactive oxygen species (ROS) production HG-treated microglia. Interestingly, treatment promoted process formation extension via Akt/Cdc42 pathway under both normal HG-stimulated conditions, indicating resting morphology Taken together, our study revealed for first time anti-inflammatory effects inflammation, which might become potential therapeutic option obesity prevention treatment.
Язык: Английский
Процитировано
17