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Krakhmal N.V.
Zavyalova M.V.
Published: Jan. 1, 2015
Cancer invasion and the ability of malignant tumor cells for directed migration and metastasis have remained a focus of research for many years. Numerous studies have confirmed the existence of two main patterns of cancer cell invasion: collective cell migration and individual cell migration, by which tumor cells overcome barriers of the extracellular matrix and spread into surrounding tissues. Each pattern of cell migration displays specific morphological features and the biochemical/molecular genetic mechanisms underlying cell migration. Two types of migrating tumor cells, mesenchymal (fibroblast-like) and amoeboid, are observed in each pattern of cancer cell invasion. This review describes the key …
Bryzgunova O.E.
Laktionov P.P.
Published: Jan. 1, 2015
Cell-free nucleic acids (cfNA) may reach the urine through cell necrosis or apoptosis, active secretion of nucleic acids by healthy and tumor cells of the urinary tract, and transport of circulating nucleic acids (cir-NA) from the blood into primary urine. Even though urinary DNA and RNA are fragmented, they can be used to detect marker sequences. MicroRNAs are also of interest as diagnostic probes. The stability of cfNA in the urine is determined by their structure and packaging into supramolecular complexes and by nuclease activity in the urine. This review summarizes current data on the sources of urinary cfNA, their …
Malyuchenko N.V.
Kotova E.Y.
Kulaeva O.I.
Kirpichnikov M.P.
Studitskiy V.M
Published: Jan. 1, 2015
The poly (ADP-ribose) polymerase 1 (PARP1) enzyme is one of the promising molecular targets for the discovery of antitumor drugs. PARP1 is a common nuclear protein (1-2 million molecules per cell) serving as a “sensor” for DNA strand breaks. Increased PARP1 expression is sometimes observed in melanomas, breast cancer, lung cancer, and other neoplastic diseases. The PARP1 expression level is a prognostic indicator and is associated with a poor survival prognosis. There is evidence that high PARP1 expression and treatment-resistance of tumors are correlated. PARP1 inhibitors are promising antitumor agents, since they act as chemo- and radiosensitizers in the conventional …
Oksana V. Vaganova
Svyatoslav V. Yevdokimov
Natalia E. Solovjeva
Published: Jan. 1, 2020
Agriculture is one of the most important priority sectors of the national economy, which provides the country's foodsecurity. But there are many problems in the activ-ities of agricultural producers, connected to the general taxation regime and the large tax burden.The purpose of this article is to study the current Unified Agricultural Tax (UAT), identify the positive and negative aspects of the application of these special tax re-gimes, as well as identify the main instruments of state support for agricultural pro-ducers.The problems that were solved during the writing these work were to substantiate the feasibility of Unified Agricultural Tax introduction for …
Natalia I. Bykanova
Daria V. Gordya
Denis V. Evdokimov
Published: Jan. 1, 2020
Due to a number of negative events for the Russian economy, the process of digitaliza-tion and implementation of financial technology (fintech) may become the main com-petitive advantages to determine the growth prospects of the banking business of Russia in the short and medium term. In addition to projects implemented with the support of the government and the Bank of Russia, large Russian banks are currently investing heavily in fintech and are actively implementing innovative pilot projects. The article reveals the key technologies of digital transformation in Russia are technologies such as Big Data and predictive analytics, artificial intelligence, robotics, machine …
Goy A.M.
Gapon N.V.
Kuznets D.O.
Voskoboynikova G.L.
Published: Jan. 1, 2016
In the conditions of introduction of the proper practice of production of medicinal facilities on pharmaceutical enterprises in Ukraine, it is necessary to develop effective measures of projects management for creation of favourable conditions for modernisation of pharmaceutical production, innovative management and management of development projects. The optimization of pharmaceutical production of injection preparations, modernisation of the pharmaceutical industries, is being implemented in accordance with the standards of GM. Risks-control of pharmaceutical production of hi-tech parenteral preparations on a new level is carried out at the following stages: preparation of raw material, preparation of facilities and equipment; the process of …
Zhuravlyova Larysa Vоlоdуmіrіvna
Lopina Nataliya Andreevna
Kuznetsov Igor Vоlоdуmirovich
Lopin Dmytro Oleksandrovich
Kramarenko Irina Anatolievna
Sumanova Irina Anatolievna
Published: Jan. 1, 2015
The article describes the etiologic role of various factors such as chronic rheumatic heart disease, bacterial endocarditis, aortic valve stenosis, hypertension, coronary heart disease, including acute myocardial infarction, degenerative disease of the valves, connective tissue diseases, chest trauma, sys-temic lupus erythematosus, con-genital heart disease which leading to the mitral valve chords rupture, gives the current classification of the nosology and also features of manifestation and clinical course. The authors also described a clinical case of mitral valve posterior leaflet chord rupture in the patient with hypertension, ischemic heart disease and chronic obstructive pulmonary disease, which reflects all the stages of …
Koshkin Roman
Ossadtchi Alex
Shtyrov Yury
Published: Dec. 14, 2017
Simultaneous interpreting (SI) is difficult to reduce to an efficient and ecologically valid experimental paradigm allowing the measurement of working memory (WM) and attention — key components of all cognitive models of SI. These models could be validated and further refined in light of electrophysiological evidence. Here we propose a novel method for estimating WM load and report the results of our electroencephalographic study that lend support to the prediction of the Efforts Model of SI (Gile, 1988). In particular, this model predicts that increased WM load impairs the processing of auditory stimuli. Consistent with the model, the P1 and …
Kseniya Absatova
Published: April 1, 2016
In the current study, two standardized English-language assessments, the AWMA by T.P. Alloway (2007) and the WMRS (Alloway, Gathercole, & Kirkwood, 2008), were translated into Russian. The translated version of the AWMA was undertaken by 51 adults and 73 primary school children, and the translated version of the WMRS was completed by the teachers who worked with those children. The WMRS is a questionnaire list for teachers with 20 items which describe possible behavior manifestations of poor working memory in the classroom. The AWMA is a computer test battery with 12 subtests which aim to assess verbal short-term memory, verbal …
Inga I. Poletaeva
Zoya A. Zorina
Published: Sept. 26, 2014
One of the urgent problems in cognitive studies and in neurobiology as a whole is to delineate the impact of genetic factors in the variability of animal cognitive abilities. The concept of animal cognition is frequently used in a broad sense to include all phenomena with behavioral manifestations of neural plasticity. The variable phenomena related to animal cognition could be subdivided into two main categories, although only the first of them will be analyzed in this paper. The first category is represented by “basal” cognitive abilities, which embrace spatial cognitive behavior and elementary reasoning (simple logic task solutions). The second …