Survival guide: Escherichia coli in the stationary phase

Pletnev P.I.,

Bogdanov A.А.,

Dontsova O.А.,

Osterman I.А.,

Sergiev P.V.

Published: Jan. 1, 2015

This review centers on the stationary phase of bacterial culture. The basic processes specific to the stationary phase, as well as the regulatory mechanisms that allow the bacteria to survive in conditions of stress, are described.

PARP1 Inhibitors: Antitumor Drug Design

Malyuchenko N.V.,

Kotova E.Y.,

Kulaeva O.I.,

Kirpichnikov M.P.,

Studitskiy V.M

Published: Jan. 1, 2015

The poly (ADP-ribose) polymerase 1 (PARP1) enzyme is one of the promising molecular targets for the discovery of antitumor drugs. PARP1 is a common nuclear protein (1-2 million molecules per cell) serving as a “sensor” for DNA strand breaks. Increased PARP1 expression is sometimes observed in melanomas, breast cancer, lung cancer, and other neoplastic diseases. The PARP1 expression level is a prognostic indicator and is associated with a poor survival prognosis. There is evidence that high PARP1 expression and treatment-resistance of tumors are correlated. PARP1 inhibitors are promising antitumor agents, since they act as chemo- and radiosensitizers in the conventional …

Overview of changes in the taxation of agricultural producers In Russia

Oksana V. Vaganova,

Svyatoslav V. Yevdokimov,

Natalia E. Solovjeva

Published: Jan. 1, 2020

Agriculture is one of the most important priority sectors of the national economy, which provides the country's foodsecurity. But there are many problems in the activ-ities of agricultural producers, connected to the general taxation regime and the large tax burden.The purpose of this article is to study the current Unified Agricultural Tax (UAT), identify the positive and negative aspects of the application of these special tax re-gimes, as well as identify the main instruments of state support for agricultural pro-ducers.The problems that were solved during the writing these work were to substantiate the feasibility of Unified Agricultural Tax introduction for …

Trends and patterns of the banking sector digitalization process

Natalia I. Bykanova,

Daria V. Gordya,

Denis V. Evdokimov

Published: Jan. 1, 2020

Due to a number of negative events for the Russian economy, the process of digitaliza-tion and implementation of financial technology (fintech) may become the main com-petitive advantages to determine the growth prospects of the banking business of Russia in the short and medium term. In addition to projects implemented with the support of the government and the Bank of Russia, large Russian banks are currently investing heavily in fintech and are actively implementing innovative pilot projects. The article reveals the key technologies of digital transformation in Russia are technologies such as Big Data and predictive analytics, artificial intelligence, robotics, machine …

Clinical case of acute chord rupture of the mitral valve posterior leaflet in older patient with comorbidities

Zhuravlyova Larysa Vоlоdуmіrіvna,

Lopina Nataliya Andreevna,

Kuznetsov Igor Vоlоdуmirovich,

Lopin Dmytro Oleksandrovich,

Kramarenko Irina Anatolievna,

Sumanova Irina Anatolievna

Published: Jan. 1, 2015

The article describes the etiologic role of various factors such as chronic rheumatic heart disease, bacterial endocarditis, aortic valve stenosis, hypertension, coronary heart disease, including acute myocardial infarction, degenerative disease of the valves, connective tissue diseases, chest trauma, sys-temic lupus erythematosus, con-genital heart disease which leading to the mitral valve chords rupture, gives the current classification of the nosology and also features of manifestation and clinical course. The authors also described a clinical case of mitral valve posterior leaflet chord rupture in the patient with hypertension, ischemic heart disease and chronic obstructive pulmonary disease, which reflects all the stages of …

Feasibility studies of the design of pharmaceutical development and industrial introduction of parenteral preparations on the basis of recombinant proteins

Goy A.M.,

Gapon N.V.,

Kuznets D.O.,

Voskoboynikova G.L.

Published: Jan. 1, 2016

In the conditions of introduction of the proper practice of production of medicinal facilities on pharmaceutical enterprises in Ukraine, it is necessary to develop effective measures of projects management for creation of favourable conditions for modernisation of pharmaceutical production, innovative management and management of development projects. The optimization of pharmaceutical production of injection preparations, modernisation of the pharmaceutical industries, is being implemented in accordance with the standards of GM. Risks-control of pharmaceutical production of hi-tech parenteral preparations on a new level is carried out at the following stages: preparation of raw material, preparation of facilities and equipment; the process of …

Attention, Working Memory and Listening in Simultaneous Interpretation

Koshkin Roman,

Ossadtchi Alex,

Shtyrov Yury

Published: Dec. 14, 2017

Simultaneous interpreting (SI) is difficult to reduce to an efficient and ecologically valid experimental paradigm allowing the measurement of working memory (WM) and attention — key components of all cognitive models of SI. These models could be validated and further refined in light of electrophysiological evidence. Here we propose a novel method for estimating WM load and report the results of our electroencephalographic study that lend support to the prediction of the Efforts Model of SI (Gile, 1988). In particular, this model predicts that increased WM load impairs the processing of auditory stimuli. Consistent with the model, the P1 and …

Applying Automated Working Memory Assessment and Working Memory Rating Scale in Russian Population

Kseniya Absatova

Published: April 1, 2016

In the current study, two standardized English-language assessments, the AWMA by T.P. Alloway (2007) and the WMRS (Alloway, Gathercole, & Kirkwood, 2008), were translated into Russian. The translated version of the AWMA was undertaken by 51 adults and 73 primary school children, and the translated version of the WMRS was completed by the teachers who worked with those children. The WMRS is a questionnaire list for teachers with 20 items which describe possible behavior manifestations of poor working memory in the classroom. The AWMA is a computer test battery with 12 subtests which aim to assess verbal short-term memory, verbal …

Be Prepared: The Effect of Expectations on Inattentional Blindness

Nika Adamian,

Maria Kuvaldina

Published: Sept. 18, 2014

The influence of expectation on inattentional blindness (IB) was investigated using a lexical-based IB task. In two experiments, 235 participants performed word compilations from briefly presented letters and combinations of letters with an unexpected syllable appearing in one of the trials. In Experiment 1, we varied the frequency and grammatical form ofthe presented words, evaluating the role of “general” and “contextual” expectations. The results showed the effect of frequency but not of the grammatical form of the words. Experiment 2 controlled for the role of the state of completion of the word compilation in generating “contextual” expectations. We varied two …

The Dopamine Impels Us to Action as Suggested by the Neuronal Activity in the Ventral Tegmental Area during Avoidance Conditioning

Natalia Yu. Ivlieva,

Natalia O. Timofeeva,

Dmitry A. Ivliev

Published: May 31, 2014

The mesolimbic dopamine system is believed to be a key component in the processing of rewarding information by the brain, although the precise nature of dopamine release remains unknown. Avoidance conditioning combines reward (positive) and aversion (negative) phenomena. Here the activity of 60 neurons in the ventral tegmental area (VTA) was studied in freely moving rabbits during the acquisition and performance of an active avoidance. A total of 48 % of the recorded neurons responded to the conditioned stimulus (CS). A significant predominance of excitatory responses to the (CS) was demonstrated. Two main patterns of cell responses to the CS …