European Medical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 43 - 46
Published: Dec. 12, 2024
Language: Английский
JAMA, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
This JAMA Patient Page describes ovarian aging, its effect on fertility, and strategies to address infertility due aging.
Language: Английский
Citations
0
Reproductive BioMedicine Online, Journal Year: 2025, Volume and Issue: 50(4), P. 104787 - 104787
Published: April 1, 2025
Since the early 1970s, family planning policies aiming to reduce global population growth have been successful. Currently, more than 50% of all countries are (way) below replacement level 2.1 child per woman. Underpopulation causes distinct society challenges in many countries. More focus on family-building strategies (including decreasing barriers for people who would like establish a family) is urgently needed.
Language: Английский
Citations
0
Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: 169, P. 104538 - 104538
Published: May 8, 2025
Language: Английский
Citations
0
Reproductive Biology and Endocrinology, Journal Year: 2025, Volume and Issue: 23(1)
Published: May 10, 2025
The use of preimplantation genetic testing for aneuploidy (PGT-A) allows the selection euploid embryos and has been thought to improve outcomes in ART, particularly women ≥ 35 years old. However, little is known regarding PGT-A utilization among minority United States (US). objective this study was determine trend US women. We conducted a retrospective cohort using Society Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) database. included initial autologous ART cycles performed between 2014 2020. assessed rate by race/ethnicity. This 150,604 287,979 non-PGT-A cycles. overall utilization, regardless race/ethnicity, increased from 11.5 49.0% (p < 0.001) over seven years. Of all cycles, 33% White used PGT-A, comparison 24% Black women, 31% Hispanic 44% Asian 0.001). Multiple Logistic Regression (MLR) determined race/ethnicity as an independent predictor when adjusting age, BMI, AMH Compared MLR showed that were 35% 16% less likely (aOR = 0.65, 95% CI 0.63-0.67, aOR 0.86, 0.84-0.88, respectively, p In contrast, 41% 1.41, 1.39-1.44) more Overall, older 71% 1.71, 1.69-1.74) compared younger than Despite significant increase 7 years, consistently marked contrast
Language: Английский
Citations
0
Biology of Reproduction, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 23, 2024
Abstract Natural ovarian aging is one of the major causes for declining fertility in female animals, which has become an insurmountable issue human reproduction clinics and assisted reproductive technology procedures. Nevertheless, molecular basis oocyte remains poorly understood, feasible improvement strategies are unavailable. In present study, vivo supplementation pyrroloquinoline-quinone effectively elevated fecundity reproductively aged mice by balancing hormonal secretion, harmonizing estrus cycle, eliminating fibrosis. Moreover, quality also increased after administration from various aspects, including nuclear cytoplasmic maturation competency, fertilization capacity, pre-implantation embryonic development potential. Transcriptomic analysis identified target pathways that might mediate pyrroloquinoline-quinone’s effects oocytes. Specifically, it was demonstrated restored mitochondrial dynamics lysosomal function to remove excessive reactive oxygen species suppress apoptosis Jointly, these findings demonstrate efficacious method restore compromised ovary damaged mice, be a potential clinical therapy women advanced maternal age with infertility.
Language: Английский
Citations
1
European Medical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 43 - 46
Published: Dec. 12, 2024
Language: Английский
Citations
0
European Medical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 43 - 46
Published: Dec. 12, 2024
Language: Английский
Citations
0