Annales de Dermatologie et de Vénéréologie - FMC, Journal Year: 2023, Volume and Issue: 3(8), P. 8S41 - 8S49
Published: Dec. 1, 2023
Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10
Published: Nov. 22, 2023
Unraveling the multidimensional complexities of melanoma has required concerted efforts by dedicated community researchers and clinicians battling against this deadly form skin cancer. Remarkable advances have been made in realm epidemiology, classification, diagnosis, therapy melanoma. The treatment advanced melanomas entered golden era as targeted personalized therapies emerged that significantly altered mortality rate. A paradigm shift approach to prognosis, staging is underway, fueled discoveries genetic alterations melanocytic neoplasms. morphologic clinicopathologic classification expected be replaced a more precise molecular based one. As validated, convenient, cost-effective molecular-based tests emerge, diagnostics will play greater role clinical histologic diagnosis Artificial intelligence augmented make process streamlined efficient. accurate model prognosis emerging on understanding This contribution summarizes recent prognosis.
Language: Английский
Citations
27
BMJ evidence-based medicine, Journal Year: 2024, Volume and Issue: 29(3), P. 156 - 161
Published: Jan. 19, 2024
Objectives To quantify the proportion of melanoma diagnoses (invasive and in situ) USA that might be overdiagnosed. Design In this ecological study, incidence mortality data were collected from Surveillance, Epidemiology End Results 9 registries database. DevCan software was used to calculate cumulative lifetime risk being diagnosed with between 1975 2018, adjustments made for changes longevity factors over study period. Setting USA. Participants White American men women (1975–2018). Main outcome measures The primary excess diagnosis 1976 2018 (adjusted year competing factors), which inferred as likely overdiagnosis. secondary an each unadjusted). Between adjusted increased 3.2% (1 31) 6.4% 16) among white men, 1.6% 63) 4.5% 22) women. Over same period, situ 0.17% 588) 2.7% 37) 0.08% 1250) 2.0% 50) An estimated 49.7% melanomas 64.6% overdiagnosed 2018. Among people situ, 89.4% 85.4% Conclusions Melanoma overdiagnosis Americans is significant increasing time 44 000 39 A large are cancers, pointing a potential focus intervention.
Language: Английский
Citations
8
JAMA Dermatology, Journal Year: 2024, Volume and Issue: 160(5), P. 495 - 495
Published: Feb. 14, 2024
Importance Most of the rapid increase in cutaneous melanoma incidence US has been localized disease that is treated surgically and associated with high survival rates. However, little known about psychological well-being survivors US. Objective To explore lived experiences fear cancer recurrence among melanoma. Design, Setting, Participants This was a qualitative survey-based study used semistructured interviews Fear Cancer Recurrence Inventory short form (FCRI-SF) survey tool participants recruited from an academic dermatology practice affiliated University Texas, Austin. Interviews were completed via telephone or person August 2021 to September 2022. Each 9 items FCRI-SF rated on 5-point Likert scale, scored 0 4, maximum possible score 36 points. Data analyses performed February 2022 June 2023. Main Outcomes Measures Semistructured analyzed for themes subthemes The scores tabulated, 13 greater identifying potential cases clinically significant recurrence. Results In all, 51 (mean [SD] age, 49.5 [11.7] years; 34 [67%] female 17 [33%] male) history (stage 0-IIA) interview survey. Among them, (33%) had survived diagnosis stage melanoma, remainder, at least 1 invasive I-IIA). revealed several themes: (1) emotions surrounding follow-up appointments, (2) intensity surveillance, (3) lifestyle changes regarding sun exposure, (4) thoughts life death. Thirty-eight above threshold clinical Conclusions Relevance found despite having excellent prognosis, some even those who 0, have rates intense survivorship affect their well-being.
Language: Английский
Citations
6
Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16
Published: March 3, 2025
Introduction Melanoma, a highly aggressive malignancy characterized by rapid metastasis and elevated mortality rates, predominantly originates in cutaneous tissues. While surgical interventions, immunotherapy, targeted therapies have advanced, the prognosis for advanced-stage melanoma remains dismal. Globally, incidence continues to rise, with United States alone reporting over 100,000 new cases 7,000 deaths annually. Despite exponential growth of tumor data facilitated next-generation sequencing (NGS), current analytical approaches emphasize single-gene analyses, neglecting critical insights into complex gene interaction networks. This study aims address this gap systematically exploring immune regulatory dynamics progression. Methods We developed bidirectional, weighted, signed, directed topological network compare transcriptional landscapes between benign melanocytic nevi melanoma. Advanced analysis tools were employed identify structural disparities functional module shifts. Key driver genes validated through centrality metrics. Additionally, deep learning models implemented predict drug-target interactions, leveraging molecular features derived from analyses. Results Significant divergences emerged networks, dominant modules transitioning cell cycle regulation lesions DNA repair migration pathways malignant tumors. A group genes, including AURKA, CCNE1, APEX2, EXOC8, identified as potential orchestrators microenvironment remodeling during transformation. The framework successfully predicted 23 clinically actionable drug candidates targeting these drivers. Discussion observed shift invasion-related provides mechanistic progression, suggesting early therapeutic machinery might mitigate metastatic potential. hub particularly AURKA DDX19B, represent novel immunomodulatory interventions. Our computational prediction strategy bridges clinical translation, offering paradigm precision oncology Future studies should validate targets preclinical explore network-based biomarkers detection.
Language: Английский
Citations
0
JDDG Journal der Deutschen Dermatologischen Gesellschaft, Journal Year: 2025, Volume and Issue: unknown
Published: April 15, 2025
Summary The strength of evidence supporting a 2‐step wide local excision (WLE) with 5 mm safety margins for melanoma in situ non‐lentigo maligna (non‐LM) type, compared narrower margins, is unclear. This review aims to compare the frequency recurrence (LR) different after complete surgical (R0) non‐LM MIS. We performed systematic literature search PubMed, Scopus, and Cochrane Library up March 17, 2024. PRISMA checklist was used. Of 3,047 articles retrieved, seven retrospective studies were included, enrolling total 1,526 MIS cases excised clear WLE (6 studies) or Mohs surgery (1 study). Most located on trunk/extremities (68%–100%). Narrower used four studies, ranging from no 4 mm, there only one LR. Standard wider remaining three reporting two median follow‐up ranged 48 months 6.6 years. overall certainty quality very low. These findings our highlight that current guidelines recommending re‐excision initial lack strong support this practice.
Language: Английский
Citations
0
P A Herzen Journal of Oncology, Journal Year: 2025, Volume and Issue: 14(2), P. 19 - 19
Published: April 28, 2025
Melanoma is a malignant skin tumor with high level of metastasis and mortality. Objective. Determination the role parameters for regional lymphogenic in prognosis disease. Material methods. The results scintigraphic, cytological, immunocytochemical, histological immunohistochemical methods primary tumors lymph nodes biopsies 93 patients melanoma were analyzed. Results. A positive correlation was found between number signal disease progression (Pearson coefficient 0.85). lymphocollectors 0.89). detected when localized on trunk 32% cases, lower extremities — 29.6%, upper 18.8% cases. stage II III noted 72 months after surgical treatment, 59.3% occurred first year follow-up. In case situ, diagnosed 144 surgery. Conclusion. significantly more often presence than 1 node one collector. frequency our study maximal within 12 surgery; follow-up, single patient 0 melanoma.
Language: Английский
Citations
0
JAMA Dermatology, Journal Year: 2024, Volume and Issue: 160(8), P. 874 - 874
Published: Aug. 1, 2024
The incidence of melanoma in situ (MIS) has increased significantly over the past decades, and traditional guidelines for treatment MIS have been excision with a 5-mm clinical margin; however, current Australian other now recommend 5- to 10-mm margins. This changed recommendation was largely driven by outcomes studies using Mohs micrographic surgery, recent surgery are advocating even wider excisions up 18 mm clearance.
Language: Английский
Citations
3
Health & Place, Journal Year: 2024, Volume and Issue: 89, P. 103328 - 103328
Published: Aug. 1, 2024
We aimed to examine associations between ultraviolet (UV) exposure and mortality among older adults in the United Kingdom (UK). used data from UK Biobank participants with two UV exposures, validated measured vitamin D levels: solarium use annual average residential shortwave radiation. Associations all-cause cause-specific were examined as adjusted hazard ratios. The exposures inversely associated all-cause, cardiovascular disease (CVD) cancer mortality. Solarium users also at a lower risk of non-CVD/non-cancer benefits may outweigh risks low-sunlight countries.
Language: Английский
Citations
3
Clinical and Experimental Dermatology, Journal Year: 2023, Volume and Issue: 49(3), P. 218 - 225
Published: Nov. 14, 2023
Lentigo maligna (LM) is a melanoma in situ with distinct clinical features and histology. It commonly affects men after the sixth decade of life. Incidence rates LM have increased based on early 21st century data from different countries; however, are suboptimal. Data England show plateauing crude incidence between 2013 2019. By comparison, invasive other types appears younger age groups (median 58 67 years old, respectively) rising. The most important risk factors for include fair skin cumulative ultraviolet solar radiation exposure. Although limited to epidermis connected adnexa, it may progress melanoma. reported rate malignant progression varies, reflecting challenge epidemiology research as often lesions removed diagnosis. poses diagnosis management. can be diagnosed clinically or dermoscopically, histopathological assessment biopsied tissue remains gold standard. Reflectance confocal microscopy allows better appreciation complexity at cellular level, progressing beyond margins. Management involve Mohs micrographic surgery excision, although recurrence occur even 5 mm Imiquimod cream effective, but incomplete treatment has been reported. Conservative management observation radiotherapy used selected patients' cases. Five-year net survival excellent. This paper reviews natural history, epidemiology, aetiology, pathogenesis, LM.
Language: Английский
Citations
8
Bioengineering, Journal Year: 2024, Volume and Issue: 11(7), P. 694 - 694
Published: July 9, 2024
In recent years, the progressively escalating incidence and exceptionally high fatality rate of cutaneous melanoma have drawn attention numerous scholars. Magnetic induction hyperthermia, as an efficacious tumor treatment modality, has been promoted applied in therapy some tumors. this paper, atop mice's heads was chosen research subject, a magnetic hyperthermia approach based on Helmholtz coils field excitation investigated designed. The influence electromagnetic thermal organisms addressed through modeling by COMSOL simulation software. results showed that maximum values induced electric strength mouse tissues were 63.1 V/m 8.5621 mT, respectively, which reached threshold value required for hyperthermia. maxima intensity brain are, 35.828 8.57 mT. Approximately 93% tissue can reach 42 °C, temperature is 44.2 °C. Within range, large quantity cells be successfully to undergo apoptosis without harming normal cells, therapeutic effect favorable.
Language: Английский
Citations
2