Mechanisms of action of fluvoxamine for COVID-19: a historical review

Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 27(4), P. 1898 - 1907

Published: Jan. 7, 2022

Language: Английский

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Sexual dimorphism in COVID-19: potential clinical and public health implications

The Lancet Diabetes & Endocrinology, Journal Year: 2022, Volume and Issue: 10(3), P. 221 - 230

Published: Feb. 1, 2022

Language: Английский

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SARS-CoV-2, fertility and assisted reproduction

Human Reproduction Update, Journal Year: 2022, Volume and Issue: 29(2), P. 177 - 196

Published: Nov. 14, 2022

In 2020, SARS-CoV-2 and the COVID-19 pandemic had a huge impact on access to provision of ART treatments. Gradually, knowledge virus its transmission has become available, allowing activities resume. Still, questions human gametes fertility remain.

Language: Английский

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Impact of COVID-19 on the Endocrine System: A Mini-review

Endocrinology, Journal Year: 2021, Volume and Issue: 163(1)

Published: Sept. 20, 2021

The coronavirus disease 2019 (COVID-19) pandemic continues to exert a significant impact on global health care systems, causing devastating mortality and morbidity. As time passes our understanding of this novel respiratory virus deepens, it is increasingly clear that its effects extend beyond the system. responsible for COVID-19, severe acute syndrome 2, obtains cellular access through angiotensin-converting enzyme 2 (ACE2) receptor in process requiring transmembrane serine protease (TMPRSS2) protein. Both ACE2 TMPRSS2 are widely expressed many endocrine glands. This, along with several case reports thyroid pituitary disruption patients has resulted interest Indeed, as abated by increasing availability effective vaccines, there focus long-term COVID-19 survivors. This review summarizes data investigating each axes guide appropriate investigations optimal management.

Language: Английский

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Effects of COVID-19 and mRNA vaccines on human fertility

Human Reproduction, Journal Year: 2021, Volume and Issue: 37(1), P. 5 - 13

Published: Oct. 16, 2021

The coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has precipitated a global health crisis of unprecedented proportions. Because its impact, multiple COVID-19 vaccines are being rapidly developed, approved and manufactured. Among them, mRNA considered as ideal candidates with special advantages to meet this challenge. However, some serious adverse events have been reported after their application, significantly increasing concerns about the safety efficacy doubts necessity vaccination. Although several fertility societies announced that unlikely affect fertility, there no denying current evidence very limited, one reasons for vaccine hesitancy in population, especially pregnant women. Herein, we provide an in-depth discussion on involvement male female reproductive systems during SARS-CoV-2 infection or On hand, despite low risk system fetus, could pose enormous threat human health. other our review indicates both men women, problems increased pregnancy outcomes vaccination, and, particular, benefits maternal antibodies transferred through placenta outweigh any known potential risks. Thus, case rapid spread COVID-19, although further research still required, larger population-based longitudinal study, it obviously wise option be vaccinated instead suffering from symptoms virus infection.

Language: Английский

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COVID-19 and the Endocrine System: A Comprehensive Review on the Theme

Journal of Clinical Medicine, Journal Year: 2021, Volume and Issue: 10(13), P. 2920 - 2920

Published: June 29, 2021

The review aimed to summarize advances in the topic of endocrine diseases and coronavirus disease 2019 (COVID-19).Scientific institutional websites databases were searched data collected organized, when plausible, angle discussion toward following clinical issues. (1) Are patients with COVID-19 at higher risk developing acute or late-onset dysfunction? (2) May underlying dysfunctions be considered factors for poor prognosis once infection has occurred? (3) there defined strategies manage despite pandemic-related constraints? Herein, authors only relevant more frequently observed disorders related hypothalamic-pituitary region, thyroid parathyroid glands, calcium-phosphorus homeostasis osteoporosis, adrenal gonads. Main. Data highlight basis some pathophysiological mechanisms anatomical alterations Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-induced dysfunctions. Some conditions, such as insufficiency cortisol excess, may worse progression occurred. These at-risk populations require adequate education avoid SARS-CoV-2 adequately medical therapy during pandemic, even emergencies. Endocrine management underwent a palpable restraint, especially procedures requiring obligate access healthcare facilities diagnostic therapeutic purposes. Strategies triage prioritize consultations, laboratory, instrumental evaluations, digital telehealth solutions should implemented better deal this probably long-term situation.

Language: Английский

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Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model

mBio, Journal Year: 2021, Volume and Issue: 12(4)

Published: July 13, 2021

Men experience more severe outcomes from coronavirus disease 2019 (COVID-19) than women. Golden Syrian hamsters were used to explore sex differences in the pathogenesis of a human clinical isolate acute respiratory syndrome 2 (SARS-CoV-2).

Language: Английский

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High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study

Emerging Microbes & Infections, Journal Year: 2021, Volume and Issue: 10(1), P. 1807 - 1818

Published: Jan. 1, 2021

Male sex was repeatedly identified as a risk factor for death and intensive care admission. However, it is yet unclear whether hormones are associated with disease severity in COVID-19 patients. In this study, we analysed hormone levels (estradiol testosterone) of male female patients (n = 50) admitted to an unit (ICU) comparison control non-COVID-19 at the ICU 42), most prevalent comorbidity (coronary heart diseases) present within cohort 39) healthy individuals 50). We detected significantly elevated estradiol critically ill compared all cohorts. Testosterone were reduced No statistically significant differences patients, albeit similar trends towards observed. Linear regression analysis revealed that among broad range cytokines chemokines analysed, IFN-γ positively Furthermore, more likely receive ECMO treatment. Thus, herein disturbance metabolism might hallmark

Language: Английский

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Testosterone in males with COVID‐19: A 7‐month cohort study

Andrology, Journal Year: 2021, Volume and Issue: 10(1), P. 34 - 41

Published: Aug. 19, 2021

Circulating testosterone levels have been found to be reduced in men with severe acute respiratory syndrome coronavirus 2 infection, COVID-19, lower being associated more clinical outcomes.We aimed assess total and the prevalence of still suggesting for hypogonadism at 7-month follow-up a cohort 121 who recovered from laboratory-confirmed COVID-19.Demographic, clinical, hormonal values were collected all patients. Hypogonadism was defined as ≤9.2 nmol/L. The Charlson Comorbidity Index used score health-significant comorbidities. Descriptive statistics multivariable linear logistic regression models tested association between laboratory variables assessment.Circulating increased compared hospital admittance (p < 0.0001), while luteinizing hormone 17β-estradiol significantly decreased (all p ≤ 0.02). Overall, 106 (87.6%) patients, but further 12 (9.9%) patients follow-up, where level suggestive observed 66 (55%) Baseline (OR 0.36; = 0.03 [0.14, 0.89]) independently after adjusting age, BMI, IL-6 admittance.Although over time than 50% disease had circulating condition follow-up. In many 10% cases, even decreased. Of relevance, higher burden comorbid conditions presentation, probability recovery time.

Language: Английский

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COVID-19 vaccines: Considering sex differences in efficacy and safety

Contemporary Clinical Trials, Journal Year: 2022, Volume and Issue: 115, P. 106700 - 106700

Published: Feb. 8, 2022

Language: Английский

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