Hits and Misses: Digital Contact Tracing in a Pandemic DOI Creative Commons
Maryanne Garry, Rachel Zajac, Lorraine Hope

et al.

Perspectives on Psychological Science, Journal Year: 2023, Volume and Issue: 19(4), P. 675 - 685

Published: June 30, 2023

Traditional contact tracing is one of the most powerful weapons people have in battle against a pandemic, especially when vaccines do not yet exist or afford complete protection from infection. But effectiveness hinges on its ability to find infected quickly and obtain accurate information them. Therefore, inherits challenges associated with fallibilities memory. Against this backdrop, digital “dream scenario”—an unobtrusive, vigilant, recorder danger that should outperform manual every dimension. There reason celebrate success tracing. Indeed, epidemiologists report probably reduced incidence COVID-19 cases by at least 25% many countries, feat would been hard match counterpart. Yet there also speculate delivered only fraction potential because it almost completely ignored relevant psychological science. We discuss strengths weaknesses tracing, hits misses need be integrated science human behavior.

Language: Английский

Serial cross-sectional estimation of vaccine-and infection-induced SARS-CoV-2 seroprevalence in British Columbia, Canada DOI Creative Commons
Danuta M. Skowronski,

Samantha E Kaweski,

Michael A. Irvine

et al.

Canadian Medical Association Journal, Journal Year: 2022, Volume and Issue: 194(47), P. E1599 - E1609

Published: Dec. 4, 2022

The evolving proportion of the population considered immunologically naive versus primed for more efficient immune memory response to SARS-CoV-2 has implications risk assessment. We sought chronicle vaccine- and infection-induced seroprevalence across first 7 waves COVID-19 pandemic in British Columbia, Canada.

Language: Английский

Citations

47
Chronic Pulmonary Manifestations of COVID-19 Infection: Imaging Evaluation DOI
Mark C. Murphy, Brent P. Little

Radiology, Journal Year: 2023, Volume and Issue: 307(2)

Published: Jan. 24, 2023

This case presents a patient with severe COVID-19 pneumonia requiring intensive care unit admission and prolonged hospital stay. The infection resulted in long-term morbidity, functional decline, abnormal chest CT findings. mechanisms for lung injury after infection, imaging appearances, the role of follow-up are discussed.

Language: Английский

Citations

23
The omicron variant of SARS-CoV-2 drove broadly increased seroprevalence in a public university setting DOI Creative Commons
Ching‐Wen Hou,

Stacy Williams,

Guillermo Trivino-Soto

et al.

PLOS Global Public Health, Journal Year: 2025, Volume and Issue: 5(1), P. e0003893 - e0003893

Published: Jan. 3, 2025

Omicron is the comparatively most transmissible and contagious variant of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). We conducted a seroprevalence study from March 1–3, 2022, to investigate SARS-CoV-2 antibodies among individuals aged 18 years older after outbreak. The anti-receptor binding domain (RBD) was found be 96.3% (95% CI 95.2–97.2%) compared 88.2% 86.1–90%) in our previous serosurvey. For anti-nucleocapsid (NC) antibodies, 39.1% 36.6–41.7%) 19.7% 17.5–22.2%) earlier. Individuals that experienced breakthrough infections exhibited highest levels anti-RBD antibodies. Additionally, saliva samples showed promise as potential diagnostic biofluid for measuring antibody levels, they strong agreement with data obtained serum samples. near doubling anti-NC reactivity, proxy history infection, reflects contagiousness omicron variant, but may also have been influenced by more relaxed approach precautions spring 2022. Serosurveys repeated at regular intervals monitor trend community, delineate geographical spread guide containment measures communities, prompt response future outbreaks.

Language: Английский

Citations

1
Estimating SARS‐CoV‐2 infections and associated changes in COVID‐19 severity and fatality DOI Creative Commons
Valentina Marziano, Giorgio Guzzetta, Francesco Menegale

et al.

Influenza and Other Respiratory Viruses, Journal Year: 2023, Volume and Issue: 17(8)

Published: Aug. 1, 2023

Abstract Background The difficulty in identifying SARS‐CoV‐2 infections has not only been the major obstacle to control COVID‐19 pandemic but also quantify changes proportion of resulting hospitalization, intensive care unit (ICU) admission, or death. Methods We developed a model transmission and vaccination informed by official estimates time‐varying reproduction number estimate that occurred Italy between February 2020 2022. Model outcomes were compared with Italian National surveillance data infection ascertainment ratio (IAR), hospitalization (IHR), ICU (IIR), fatality (IFR) five different sub‐periods associated dominance ancestral lineages Alpha, Delta, Omicron BA.1 variants. Results that, over first 2 years pandemic, IAR ranged 15% 40% (range 95%CI: 11%–61%), peak value second half 2020. IHR, IIR, IFR consistently decreased throughout 22–44‐fold reductions initial phase period. At end study period, we an IHR 0.24% (95%CI: 0.17–0.36), IIR 0.015% 0.011–0.023), 0.05% 0.04–0.08). Conclusions Since 2021, dominant variant, rollout, shift younger ages have reduced ascertainment. same factors, combined improvement patient management care, contributed massive reduction severity COVID‐19.

Language: Английский

Citations

15
SARS-CoV-2 infection- induced seroprevalence among children and associated risk factors during the pre- and omicron-dominant wave, from January 2021 through December 2022, Thailand: A longitudinal study DOI Creative Commons
Nungruthai Suntronwong, Preeyaporn Vichaiwattana,

Sirapa Klinfueng

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(4), P. e0279147 - e0279147

Published: April 27, 2023

Background Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic in young children. Therefore, the true rate of is likely underestimated. Few data are available on infections children, and studies SARS-CoV-2 seroprevalence among children during omicron wave limited. We assessed infection-induced estimated associated risk factors for seropositivity. Methods A longitudinal serological survey was conducted from January 2021 through December 2022. The inclusion criteria were healthy between 5 7 years old their parents or legal guardians provided written informed consent. Samples tested anti-nucleocapsid (N) IgG anti-receptor binding domain (RBD) using a chemiluminescent microparticle immunoassay (CMIA), total anti-RBD immunoglobulin (Ig) detected an electrochemiluminescence (ECLIA). vaccination history collected. Results In all, 457 serum samples obtained 241 annually followed-up this survey. Of these, 201 participants at two serial time points—during pre-omicron omicron-dominant wave. Overall, induced by increased 9.1% (22/241) to 48.8% (98/201) Amongst seropositive individuals, seropositivity lower vaccinated with doses BNT162b2 than unvaccinated (26.4% vs. 56%; OR, 0.28; 95%CI: 0.14–0.58). Nevertheless, ratio cases per recalled 1.63 dominant overall infection, vaccination, hybrid immunity 77.1% (155/201) Conclusions report increase These findings highlight that help determine particularly optimize public health policies vaccine strategies pediatric population.

Language: Английский

Citations

12
Selective adaptation of SARS-CoV-2 Omicron under booster vaccine pressure: a multicentre observational study DOI Creative Commons
Ralf Duerr,

Dacia Dimartino,

Christian Marier

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 97, P. 104843 - 104843

Published: Oct. 20, 2023

High rates of vaccination and natural infection drive immunity redirect selective viral adaptation. Updated boosters are installed to cope with drifted viruses, yet data on adaptive evolution under increasing immune pressure in a real-world situation lacking.

Language: Английский

Citations

11
Concurrent Administration of COVID-19 and Influenza Vaccines Enhances Spike-Specific Antibody Responses DOI Creative Commons

Susanna E Barouch,

Taras M. Chicz, Ross Blanc

et al.

Open Forum Infectious Diseases, Journal Year: 2024, Volume and Issue: 11(4)

Published: March 13, 2024

Abstract Background The bivalent COVID-19 mRNA boosters became available in fall 2022 and were recommended alongside the seasonal influenza vaccine. However, immunogenicity of concurrent vs separate administration these vaccines remains unclear. Methods Here, we analyzed antibody responses health care workers who received booster vaccine on same day or different days through systems serology. Antibody-binding functional characterized at peak after 6 months following vaccination. Results IgG1 neutralization to SARS-CoV-2 XBB.1.5 higher as compared with vaccines. While similar results not observed for responses, no interference was noted administration. Conclusions These data suggest that may yield more durable neutralizing while maintaining against influenza.

Language: Английский

Citations

4
COVID-19 in Japan during 2020-2022: Characteristics, responses, and implications for the health care system DOI Creative Commons

Kenji Karako,

Peipei Song, Yuyan Chen

et al.

Journal of Global Health, Journal Year: 2022, Volume and Issue: 12

Published: Oct. 13, 2022

T he COVID-19 global pandemic of the past two years has changed way humans behave, governments respond to crises, and placed a heavy burden on health care systems countries in question.As 2022 begins, world is experiencing huge wave infection with Omicron variant SARS-CoV-2 due its higher transmissibility [1][2][3].Globally, number new cases reported August 19, was 837 823 [4], which 255 508 were Japan [5], accounting for 30%.Worldwide, progression epidemic response system have unique characteristics.This particularly evident declaring states emergency during peaks non-compulsory self-restraint requirements, low mortality rate, sharp decline after impact Tokyo 2020 Olympic Paralympic Games system, unprecedented rise infections current spread (Figure 1).Since first domestic case COV-ID-19 transmission January 16, 2020, experienced six waves currently seventh wave.Three been declared since April 2021.During this period, hosted (July 23-August 8, 2021) (August 24-September 5, began massive vaccination campaign.A record 5773 13, 25 975 nationwide 20, 2021.However, appeared effectively controlled

Language: Английский

Citations

18
Cumulative and undiagnosed SARS-CoV-2 infection among the staff of a medical research centre in Tokyo after the emergence of variants DOI Creative Commons
Tetsuya Mizoue, Shohei Yamamoto,

Yusuke Oshiro

et al.

Epidemiology and Infection, Journal Year: 2023, Volume and Issue: 151

Published: Jan. 1, 2023

Abstract To describe the trend of cumulative incidence coronavirus disease 19 (COVID-19) and undiagnosed cases over pandemic through emergence severe acute respiratory syndrome 2 (SARS-CoV-2) variants among healthcare workers in Tokyo, we analysed data repeated serological surveys in-house COVID-19 registry staff National Center for Global Health Medicine. Participants were asked to donate venous blood complete a survey questionnaire about diagnosis vaccine. Positive serology was defined as being positive on Roche or Abbott assay against SARS-CoV-2 nucleocapsid protein, infection either seropositive having history COVID-19. Cumulative has increased from 2.0% June 2021 (pre-Delta) 5.3% December (post-Delta). After Omicron, it substantially during 2022 (16.9% 39.0% December). As 2022, 30% those who infected past not aware their infection. Results indicate that rapidly expanded Omicron-variant epidemic Tokyo sizable number infections undiagnosed.

Language: Английский

Citations

10
Opportunities and Challenges in Using Electronic Health Record Systems to Study Postacute Sequelae of SARS-CoV-2 Infection: Insights From the NIH RECOVER Initiative DOI Creative Commons
Hannah Mandel, Shruti Shah, L. Charles Bailey

et al.

Journal of Medical Internet Research, Journal Year: 2025, Volume and Issue: 27, P. e59217 - e59217

Published: March 5, 2025

The benefits and challenges of electronic health records (EHRs) as data sources for clinical epidemiologic research have been well described. However, several factors are important to consider when using EHR study novel, emerging, multifaceted conditions such postacute sequelae SARS-CoV-2 infection or long COVID. In this article, we present opportunities improve our understanding COVID, based on lessons learned from the National Institutes Health (NIH)-funded RECOVER (REsearching COVID Enhance Recovery) Initiative, suggest steps maximize usefulness performing research.

Language: Английский

Citations

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