The associations between the energy and timing of sugar-sweetened beverage intake and phenotypic age acceleration in U.S. adults: a cross-sectional survey of NHANES 2007–2010

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 8, 2025

The relationship between sugar-sweetened beverage (SSB) intake and phenotypic age acceleration (PhenoAgeAccel) is unclear. aim of this study was to explore the associations energy timing SSB PhenoAgeAccel in adults. A cross-sectional analysis conducted using data from National Health Nutrition Examination Survey (NHANES) 2007–2010, which involved U.S. adults aged 20 79 years. assessment estimation were through 24-hour dietary recall interviews, categorizing participants into three groups: non-intake, low moderate-intake, moderate–high-intake. Furthermore, consumers divided time intervals based on timing: dawn-to-forenoon (5:00 a.m. 11:59 a.m.), noon-to-afternoon (12:00 p.m. 17:59 p.m.), dusk-to-night (18:00 4:59 a.m.). Multivariable linear regression models employed evaluate (energy timing) PhenoAgeAccel. Additionally, stratified analyses interaction conducted. obesity assessed via two distinct metrics: body roundness index (BRI) mass (BMI). Mediation investigate mediating effect After controlling for covariates, (per 100 kcal/day) positively correlated with (β = 0.179, 95% confidence interval [CI]: 0.086–0.271). moderate–high-intake group presented a significantly greater than non-intake 1.023, CI: 0.414–1.632). This remained stable across analyses. Compared those who abstained SSB, consumed during period exhibited notably elevated 0.915, 0.316–1.514). significant interactive smoking timing–PhenoAgeAccel association observed (P 0.002). revealed that both BRI BMI mediated PhenoAgeAccel, mediation proportions 16.29% 16.21%, respectively. Our positive correlation may be partially by obesity. Moreover, consuming increase

Language: Английский

---

The association between childhood hunger experiences and health in middle and old age: a longitudinal study over 10 years

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 16, 2025

A significant relationship is present between childhood hunger experiences (CHEs) and health, but explorations of the longitudinal persistence this its mediating mechanisms are still lacking. This study aims to evaluate effects CHEs on health in middle old age determine underlying mechanisms. Using data from five 2011—2020 China Health Retirement Longitudinal Study (CHARLS) 2014 Life History Survey Questionnaire, a sample 9,909 individuals aged 45 years older who participated all six surveys was obtained. We conducted panel analyses, used Probit ordinary least squares regression models analyze age, stepwise tests mediators relationship. significantly predicted self-assessment (β = −0.18; 95% CI: −0.23, −0.12), probability receiving medical treatment −0.09; −0.13, −0.05), depression −0.30; −0.35, −0.25), memory −0.13; −0.18, −0.07), cognitive function −0.26, −0.00). The showed an aggravating trend regarding function, mitigating self-assessed memory. Smoking, exercising, sleep duration were revealed as transmitting factors health. had negative impact age. While their gradually worsen, mitigated over time. Lifestyle such smoking, CHEs. Thus, status experience warrants attention.

Language: Английский

---

Multi-dimensional evidence from the UK Biobank shows the impact of diet and macronutrient intake on aging

Communications Medicine, Journal Year: 2025, Volume and Issue: 5(1)

Published: Feb. 4, 2025

The role of diet in aging is crucial, yet research findings on how specific diets influence human remain inconsistent. Understanding the relationship between dietary factors and could inform interventions to promote healthier outcomes. We analyzed data from UK Biobank baseline survey a 24-hour assessment investigate association aging. study examined 18 individual food intakes, 6 patterns, 3 macronutrient quality scores. High-dimensional Fixed Effects (HDFE) models were used assess associations measures, including telomere length, phenotypic age, brain grey/white matter volumes. Multivariable Mendelian Randomization (MVMR) was employed explore causal links consumption Our results show that are generally associated with improved outcomes HDFE analyses. Plant-based correlates increased length reduced while animal-based intake linked adverse effects. MVMR confirm benefits carbohydrate intake, reductions age (β = -0.0025; 95% CI [-0.0047, -0.0003]; p 0.0253) increases whole-brain grey volume 0.0262; [0.007, 0.046]; 0.0087). latter remains significant after multiple testing correction. This underscores biological provides robust evidence for promoting These highlight potential improve aging-related

Language: Английский

---

Association of phenotypic age acceleration with all-cause and cause-specific mortality among U.S. cancer survivors: a retrospective cohort study

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 25, 2025

Cancer survivors may experience accelerated biological aging, increasing their risk of mortality. However, the association between phenotypic age acceleration (PAA) and mortality among cancer remains unclear. This study aimed to evaluate relationship PAA all-cause mortality, cancer-specific non-cancer adult in United States. We utilized data from National Health Nutrition Examination Survey (NHANES) 1999 2018, including 2,643 (unweighted) patients aged ≥ 20 years. Phenotypic was calculated using ten physiological biomarkers, residuals regressing on chronological (age residuals, AAR) were used determine status. Participants divided into without groups based sign residuals. Weighted Cox proportional hazards regression models assess adjusting for demographic characteristics, lifestyle factors, comorbidities. Restricted cubic spline (RCS) employed explore dose-response AAR Over a median follow-up 9.16 years, 991 participants died. After multiple covariates, significantly associated with increased risks (HR = 2.07; 95% CI: 1.69–2.54), 2.15; 1.52–3.04), 2.06; 1.66–2.57). Each one-unit increase 4% all-cause, cancer-specific, 1.04; 1.03–1.05). RCS indicated linear Among U.S. survivors, is serve as an important biomarker predicting prognosis survivors.

Language: Английский

---

Construction and validation of a DNN-based biological age and its influencing factors in the China Kadoorie Biobank

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Biological age is an important measure of aging that reflects individual's physical health and linked to various diseases. Current prediction models are still limited in precision, the risk factors for accelerated remain underexplored. Therefore, we aimed develop a precise biological assess impact socio-demographic behavioral patterns on process.We utilized Deep Neural Networks (DNN) construct from participants with examinations, blood samples, questionnaires data China Kadoorie Biobank (CKB) between June 2004 December 2016. △age, calculated as residuals chronological age, was used investigate associations acceleration Socio-demographics (gender, education attainment, marital status, household income) lifestyle characteristics (body mass index [BMI], smoking, drinking, activity, sleep) were also assessed explore their acceleration. 18,261 aged 57 ± 10 years included this study. The DNN-based model has demonstrated accurate predictive performance, achieving mean absolute error 3.655 years. △age associated increased risks morbidity mortality, highest found circulatory respiratory diseases, hazard ratios 1.033 (95% CI: 1.023, 1.042) 1.078 1.027, 1.130), respectively. Socio-demographics, including being female, lower education, widowed or divorced, low income, along patterns, such underweight, insufficient poor sleep, aging. Our DNN capable constructing using commonly collected data. aging, highlighting addressing modifiable can effectively slow reduce disease risk, providing valuable insights interventions promote healthy

Language: Английский

---

Lifestyles and their relative contribution to biological aging across multiple-organ systems: Change analysis from the China Multi-Ethnic Cohort study

eLife, Journal Year: 2025, Volume and Issue: 13

Published: March 7, 2025

Background: Biological aging exhibits heterogeneity across multi-organ systems. However, it remains unclear how is lifestyle associated with overall and organ-specific which factors contribute most in Southwest China. Methods: This study involved 8396 participants who completed two surveys from the China Multi-Ethnic Cohort (CMEC) study. The healthy index (HLI) was developed using five factors: smoking, alcohol, diet, exercise, sleep. comprehensive biological ages (BAs) were calculated Klemera–Doubal method based on longitudinal clinical laboratory measurements, validation conducted to select BA reflecting related diseases. Fixed effects model used examine associations between HLI or its components acceleration of validated BAs. We further evaluated relative contribution comprehension organ systems BAs quantile G-computation. Results: About two-thirds changed scores surveys. After validation, three (the cardiopulmonary, metabolic, liver BAs) identified as reflective specific diseases included analyses BA. health alterations showed a protective association all BAs, mean shift –0.19 (95% CI −0.34, –0.03) acceleration. Diet smoking major contributors negative factors, metabolic accounting for 24% 55% respectively. Conclusions: Healthy changes inversely China, diet contributing separately. Our findings highlight potential interventions decelerate identify intervention targets limit less-developed regions. Funding: work primarily supported by National Natural Science Foundation (Grant No. 82273740) Sichuan Technology Program (Natural Province, Grant 2024NSFSC0552). CMEC funded Key Research Development 2017YFC0907305, 2017YFC0907300). sponsors had no role design, analysis, interpretation, writing this article.

Language: Английский

---

Association of body roundness index and age acceleration with type 2 diabetes: Evident from the UK Biobank

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Background: Obesity and aging are regarded as significant risk factors for type 2 diabetes(T2D). However, joint effect of body roundness index (BRI) age acceleration (ACC), novel predictors visceral the rate aging, with incident T2D remains unclear. Objective: To examine associations BRI ACC T2D. Methods: This prospective cohort study used data from UK Biobank, participants pre-existing diabetes missing were excluded in analysis. The outcome interest was Joint assessed through eight paired quartile combinations. Kaplan-Meier curves to estimate cumulative incidence, while Cox proportional-hazards regression analyze independent by gradually adjusting covariates. Results: Among 380,146 Biobank over 14.6 years follow-up, 15,262 developed survival indicated that a higher level or had Both levels positively associated (BRI:HR: 1.30, 95% CI: 1.28-1.32, ACC: HR: 1.03, 1.03-1.03). When categorized into quartiles, those top demonstrated significantly increased (BRI-Q4:HR:3.68, 95%CI: 3.35-4.04; ACC-Q4:HR:1.59, 95%CI:1.50-1.68; BRI-Q4 ACC-Q4: 6.76, 5.65-8.09). Conclusion: BRI independently T2D, showing stronger predictive capability. Their combined effects underscore their utility non-invasive screening tools risk.

Language: Английский

---

Adverse childhood experiences and long-term health in women: Accumulation of multi-morbidity

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

The impact of early-life traumatic experiences on late-life morbidity remains partly unknown. We tested the hypothesis that adverse childhood (ACE) and specifically abuse (physical, verbal or emotional, sexual) experienced during early adulthood are associated with a higher rate accumulation multi-morbidity in women. Here we show strong evidence support hypothesis. studied 1,026 women aged 21–45 years randomly selected from general population Olmsted County, Minnesota used Rochester Epidemiology Project medical records-linkage system to measure development 18 chronic conditions. had median age 41 at inclusion study were followed historically for 21 years. Women an ACE score ≥ 2 incidence 10 conditions considered separately accelerated measured as compared 0. In addition, exposed multi-morbidity. excluded possible confounding effect socioeconomic status explored series mediation events characteristics. discuss several biological social behavioral mechanisms underlying these associations.

Language: Английский

---

Adverse childhood experiences and trajectories of chronic diseases: A population-base longitudinal study

Public Health, Journal Year: 2025, Volume and Issue: 242, P. 256 - 263

Published: March 31, 2025

Language: Английский

---

Associations of exposure to volatile organic compounds with biological aging: a cross-sectional study

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 22, 2025

Language: Английский

---