Genetic causal association between type 2 diabetes, body mass index, smoking initiation and myopia：A mendelian randomization study DOI Creative Commons
Chu Zhang, Shuqin Li, Hui Wang

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: July 21, 2023

Abstract The purpose of this investigation was to explore the causal relationships between type 2 diabetes, body mass index(BMI), smoking initiation, and myopia. We utilized summary statistics from independent genome-wide association studies examine linkages among these factors. Our main analytical technique inverse-variance-weighted (IVW) method, along with weighted median mr-egger as supplements. Univariable multivariable mendelian randomization(MR) analyses were conducted, reverse MR performed assess causation.The results showed that there associations myopia initiation (odds ratio (OR) 0.984, 95% confidence interval (CI) 0.977-0.992, p=6.35×10-5), index (OR 0.989, CI 0.984-0.993, p=3.84×10-6), diabetes 1.004, 1.002-1.006, p=4.15×10-4). These remained strong even after mutual adjustment. observed no pleiotropy in exposures, found MR.In conclusion, study is first use univariable multivariate randomization confirm a relationship BMI

Language: Английский

The influence of the environment and lifestyle on myopia DOI Creative Commons
Sayantan Biswas,

Antonio El Kareh,

Mariyem Qureshi

et al.

Journal of PHYSIOLOGICAL ANTHROPOLOGY, Journal Year: 2024, Volume and Issue: 43(1)

Published: Jan. 31, 2024

Abstract Background Myopia, commonly known as near-sightedness, has emerged a global epidemic, impacting almost one in three individuals across the world. The increasing prevalence of myopia during early childhood heightened risk developing high and related sight-threatening eye conditions adulthood. This surge rates, occurring within relatively stable genetic framework, underscores profound influence environmental lifestyle factors on this condition. In comprehensive narrative review, we shed light both established potential contributors that affect development progression myopia. Main body Epidemiological interventional research consistently revealed compelling connection between increased outdoor time decreased children. protective effect may primarily be attributed to exposure characteristics natural (i.e., sunlight) release retinal dopamine. Conversely, irrespective time, excessive engagement near work can further worsen onset While exact mechanisms behind exacerbation are not fully comprehended, it appears involve shifts relative peripheral refraction, overstimulation accommodation, or complex interplay these factors, leading issues like image defocus, blur, chromatic aberration. Other spatial frequency visual environment, circadian rhythm, sleep, nutrition, smoking, socio-economic status, education have debatable independent influences development. Conclusion environment exerts significant Improving modifiable key predictors spent outdoors prevent slow intricate connections often obscure findings, making challenging disentangle their individual effects. complexity necessity for prospective studies employ objective assessments, such quantifying work, among others. These crucial gaining more understanding how various modified

Language: Английский

Citations

57
The impact of lifestyle factors on myopia development: Insights and recommendations DOI Creative Commons

Mengru Ba,

Zhijie Li

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1), P. 100010 - 100010

Published: April 1, 2024

This study evaluates the influence of various lifestyle factors, such as screen time, physical inactivity, dietary habits, and psychological stress, on development progression myopia in comparison to genetic predisposition. It underscores critical role adopting healthier lifestyles minimize risk myopia, especially genetically susceptible individuals. integrates a systematic review existing literature with empirical data assess relationship between habits providing nuanced understanding its multifaceted etiology. Comprehensive analysis from multiple institutional clinical studies. The includes research individuals across spectrum, examining factors addition influences. Analysis focused behaviors, including digital device use, activity, patterns, sleep quality relation myopia. Correlation prevalence choices susceptibility. results highlight strong association behaviors predispositions exacerbating effects detrimental habits. In particular, proactive modifications, increasing outdoor appear be effective preventing supports an integrative approach management, emphasizing modifications conjunction awareness. calls for comprehensive public health strategies address increase advocating balanced interplay maintaining health, engaging activities, promoting mental wellness counteract multifactorial risks associated development.

Language: Английский

Citations

5
The application of organoids in toxicity test of environmental pollutants DOI Creative Commons

Yuting Fang,

Huraira Akhtar,

Ji Wang

et al.

Cell organoid (Print), Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Environmental pollutants are mainly produced by human production and living, pose a serious threat to health. Health risk assessments of environmental needed in order contribute the development reasonable control measures. In comparison two-dimensional (2D) cell culture experimental animals, organoids excellent alternative models for health assessment pollutants. this review, we described application toxicity testing Finally, there was discussion unique advantages challenges as test models. It is hoped that will provide insight into field toxicology.

Language: Английский

Citations

4
Secondhand smoke (SHS) exposure is associated with an increased risk of developing myopia among nonmyopic children in China DOI Creative Commons

Yuchang Lu,

Xuewei Li, Yang Deng

et al.

BMC Ophthalmology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 10, 2025

To investigate the impact of secondhand smoke (SHS) exposure on myopia prevalence and risk among nonmyopic children in China. This was a retrospective cohort study. A total 232 aged 5–10 years were included, with 128 exposed to SHS 104 who not. Baseline characteristics such as age, sex, height, weight, spherical equivalent refraction (SER), axial length (AL), average corneal K-reading (Ave-K), intraocular pressure (IOP), pupil diameter (PD) subfoveal choroidal thickness (SFCT) measured. Follow-up assessments at 3-, 6-, 9-, 12-month visits focused changes SER AL. Behavioural parental factors, including status, education level, daily time spent near work outdoor activities collected via questionnaires from medical records. Linear regression applied identify factors that have significant elongation over 1 year. The mean myopic shift group − 0.64 ± 0.41 D/year, which significantly greater than control (-0.47 0.52 D/year) (P = 0.004). Children had did (0.26 0.14 mm vs. 0.20 0.13 mm, P 0.002). Multivariate linear analysis revealed (β 0.053, 0.002), baseline -0.054, 0.001) 0.028, 0.036) predictors elongation. study associated likelihood developing early-onset myopia. These findings indicate eradicating is highly important for preventing children, especially families young children.

Language: Английский

Citations

0
Exposure to secondhand smoke and physical disabilities in non-smokers: A national cross-sectional study with cotinine measurements from NHANES 2013–2018 DOI Creative Commons
Jiahui He, Zhounan Wu, Yuhang Liang

et al.

Tobacco Induced Diseases, Journal Year: 2025, Volume and Issue: 23(February), P. 1 - 11

Published: Feb. 21, 2025

ADHD: attention deficit hyperactivity disorder, CVD: cardiovascular diseases, LLOD: lower limit of detection, NHANES: National Health and Nutrition Examination Survey, PIR: poverty income ratio, SCL: serum cotinine levels, VIF: variance inflation factor, RCS: restricted cubic spline

Language: Английский

Citations

0
Sodium fluoride promotes myopia progression via the activation of the ferroptosis pathway by PIEZO1 and pharmacological targeting PIEZO1 represents an innovative approach for myopia treatment DOI Creative Commons
Bo Liu,

Xueting Yao,

Qinying Huang

et al.

Cell Biology and Toxicology, Journal Year: 2025, Volume and Issue: 41(1)

Published: April 2, 2025

Sodium fluoride-induced ocular damage constitutes a significant public health concern globally; however, the precise molecular mechanisms underlying this issue remain obscure. This study aims to investigate effects of sodium fluoride on myopia and offer novel theoretical foundations for future strategies in prevention control. The experimental data showed that could promote progression, through bioinformatics analysis, we found affect ferroptosis pathway. Western blotting redox kit assays further confirmed activates We also demonstrated PIEZO1 plays crucial role myopia, inhibitor (GsMTx4) can inhibit Subsequently, identified as potential target baicalin, which inhibited expression vivo vitro, by docking modeling CETSA assays. Finally, baicalin via PIEZO1. Taken together, our findings indicate progression activating pathway PIEZO1, targeting delay may provide new drug treatment future.

Language: Английский

Citations

0
Secondhand smoke exposure and ocular health: A systematic review DOI

You-Juan Zhang,

Xiu Juan Zhang,

Nan Yuan

et al.

Survey of Ophthalmology, Journal Year: 2023, Volume and Issue: 68(6), P. 1166 - 1207

Published: July 20, 2023

Language: Английский

Citations

4
Air pollutant exposure is associated with visual trajectories and visual impairment in children DOI

Keyang Zheng,

Dongling Yang,

Wenjuan Qi

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 135842 - 135842

Published: Sept. 16, 2024

Language: Английский

Citations

1
Exposure to Secondhand Smoke and Myopia in Children Aged 6 to 8 Years in Hong Kong DOI Creative Commons
Ian G. Morgan

JAMA Network Open, Journal Year: 2023, Volume and Issue: 6(5), P. e2312995 - e2312995

Published: May 11, 2023

Youjuan Zhang, PhD; Xiu Juan Nan Yuan, Yuzhou Yu Meng Wang, Fangyao Tang, Mandy P. Ng, MHM; Ian C. K. Wong, Patrick Ip, MPH; Ka Wai Kam, MSc (Epidemiology); Alvin L. Young, MMedSc; Li Jia Chen, Clement Tham, BM, BCh; Chi Pui Pang, DPhil; Jason Yam, MPH

Language: Английский

Citations

2
Administration of Nicotine Can Inhibit Myopic Growth in Animal Models DOI Creative Commons
Kate Thomson, Cindy Karouta, Regan Ashby

et al.

Investigative Ophthalmology & Visual Science, Journal Year: 2024, Volume and Issue: 65(11), P. 29 - 29

Published: Sept. 18, 2024

While previously investigating the mechanism by which atropine inhibits ocular growth, we observed that stimulation of nicotinic receptors can inhibit experimental myopia. This study expands on preliminary finding and investigates safety efficacy in inhibition growth.

Language: Английский

Citations

0