The impact of life stress on hallmarks of aging and accelerated senescence: Connections in sickness and in health

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 153, P. 105359 - 105359

Published: Aug. 15, 2023

Language: Английский

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U‐shaped association between sleep duration and biological aging: Evidence from the UK Biobank study

Aging Cell, Journal Year: 2024, Volume and Issue: 23(7)

Published: March 31, 2024

Previous research on sleep and aging largely has failed to illustrate the optimal dose-response curve of this relationship. We aimed analyze associations between duration measures predicted age. In total, 241,713 participants from UK Biobank were included. Habitual was collected baseline questionnaire. Four indicators, homeostatic dysregulation (HD), phenoAge (PA), Klemera-Doubal method (KDM), allostatic load (AL), chosen assess Multivariate linear regression models utilized. The association age followed a U-shape (All p for nonlinear <0.05). Compared with individuals who 7 h/day, multivariable-adjusted beta ≤5 ≥9 h/day 0.05 (95% CI 0.03, 0.07) 0.03 0.02, 0.05) HD, 0.08 0.01, 0.14) 0.36 0.31, 0.41) PA, 0.21 0.12, 0.30) 0.30 0.23, 0.37) KDM. Significant independent joint effects cystatin C (CysC) gamma glutamyltransferase (GGT) metrics future found. Similar results observed when conducting stratification analyses. Short long associated accelerated mediated by CysC GGT.

Language: Английский

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Association between allostatic load and breast cancer risk: a cohort study

Breast Cancer Research, Journal Year: 2023, Volume and Issue: 25(1)

Published: Dec. 19, 2023

Allostatic load (AL) reflects the collective of chronic stress during lifetime. Previous studies have shown that higher AL is associated with poor clinical outcomes among breast cancer patients. However, relationship between and risk still unclear.

Language: Английский

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Allostatic load as a predictor of postoperative complications in patients with breast cancer

npj Breast Cancer, Journal Year: 2024, Volume and Issue: 10(1)

Published: June 12, 2024

Abstract Allostatic load (AL) is a biological measure of cumulative exposure to socioenvironmental stressors (e.g., poverty). This study aims examine the association between allostatic and postoperative complications (POC) among patients with breast cancer. Females ages 18+ stage I-III cancer who received surgical management 01/01/2012-12/31/2020 were identified in Ohio State Cancer registry. The composite AL included biomarkers from cardiovascular, metabolic, immune, renal systems. High was defined as scores greater than cohort’s median (2.0). POC within 30 days surgery examined. Univariable multivariable regression analysis examined POC. Among 4459 patients, 8.2% had A higher percentage unpartnered (POC 44.7% vs no 35.5%), government-insured 48.2% 38.3%) multiple comorbidities 32% 20%). Patients developed more likely have undergone sentinel lymph node biopsy followed by axillary dissection 51.2% 44.6%). associated 29% odds (aOR 1.29, 95% CI 1.01–1.63). one-point increase 8% 1.08, 1.02-1.16) quartile 13% increased 1.13, 1.01–1.26). undergoing surgery, adverse stressors, operationalized AL, complications.

Language: Английский

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Allostatic Load in Parents and Offspring

The Journal of Cardiovascular Nursing, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Allostatic load (AL), a measure of cumulative stress-related physiological dysregulation, predicts the onset chronic diseases. We investigated relationship between AL and cardiovascular disease (CVD)-free survival in parents offspring, including sex-specific differences.

Language: Английский

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Biological embodiment of educational attainment and future risk of breast cancer: findings from a French prospective cohort

BMJ Open, Journal Year: 2025, Volume and Issue: 15(2), P. e087537 - e087537

Published: Feb. 1, 2025

Women with higher educational attainment have a risk of developing breast cancer (BC). Despite the acknowledged impact reproductive and lifestyle factors, some excess risks remain unexplained. Many studies support hypothesis that education has distinctive effect on physiological processes associated health, independently known factors. In this study, we aimed to determine whether biological embodiment could be part observed social inequalities in BC risk. We focused biomarkers from several systems examined individually, jointly through health score (BHS). Prospective cohort study. This based subsample French E3N cohort, included women data four nested case-control studies. The study 3048 postmenopausal (17% BC). first evaluated association between each biomarker, separately (N=11) by combining them into BHS, indicative an augmented hazard when elevated. Finally, explored relationships socially patterned incident BC. exhibited lower BHS comparison those (βhigh education=-0.21 (95% CI -0.42; 0.01), model 2). Specific cardiovascular (systolic blood pressure (SBP), diastolic (DBP), triglycerides (TG), high-density lipoprotein (HDL)), inflammatory (C reactive protein (CRP)) hormonal (sex hormone-binding globulin (SHBG) oestradiol) were found distributed (OR CRP-high=0.70 0.54; 0.91), OR TG-high=0.79 0.61; 1.04), DBP-high=0.69 0.53; 0.90), SBP-high=0.57 0.44; 0.74), HDL-high=0.79 0.60; 1.03), SHBG-high=0.67 0.52; 0.88), oestradiol-high=1.34 1.00; 1.79); 1). Associations persisted after adjustment for cofounders large set potential mediators two investigated markers DBP-high=0.75 0.57; 1.00), SBP-high=0.61 0.46; 0.81); No associations stratified Educational direct suggesting environment pathway mediates health. Further are needed specifically investigate

Language: Английский

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Allostatic load score and lifestyle factors in the SWAN Cohort: a longitudinal analysis

Public Health in Practice, Journal Year: 2025, Volume and Issue: 9, P. 100590 - 100590

Published: Feb. 12, 2025

Allostatic load (AL) has been used to assess chronic stress. Previous studies have assessed associations between lifestyle factors and the AL. However, those yet evaluate longitudinally. Thus, effect of on AL changes over time remains be determined. A longitudinal analysis was designed. Our study included 1976 women identified from Study Women's Health Across Nation (SWAN) who had completed at least seven waves measurements since baseline. The Poisson mixed effects model how affected time. At baseline, mean score 2.44 (range 0-11). On average, increased by 3 % (ORs = 1.03, 95 CI [1.01, 1.05]) per wave For factors, smoked cigarettes higher than never smoked. other hand, ever drank alcohol leisure physical activity time, average sleep quality lower their counterparts. We also a statistically significant interaction drinking (P < 0.01). Furthermore, we generated healthy using four above potential accumulative found that 16 for each additional unhealthy factor 1.16, 95%CI: 1.12, 1.2). This demonstrates can influence increase

Language: Английский

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The association between allostatic load and lymphedema in breast cancer survivors

Supportive Care in Cancer, Journal Year: 2025, Volume and Issue: 33(4)

Published: March 21, 2025

Abstract Purpose Allostatic load, a measure of physiological dysregulation secondary to chronic exposure socioenvironmental stressors, is associated with 30-day postoperative complications and mortality in patients breast cancer. This study aimed examine the association between allostatic load (AL) at diagnosis development cancer-related lymphedema (BCRL). Methods Patients aged 18 years or older who received surgical treatment for stage I-III cancer 2012 2020 were identified from The Ohio State University Cancer Registry. AL was calculated using biomarkers cardiovascular, metabolic, renal, immunologic systems. A high defined as > median. Logistic regression analyses examined BRCL, adjusting sociodemographic, clinical, factors. Results Among 3,609 patients, 18.86% (n = 681) developed lymphedema. higher proportion Black (11.89% vs. 7.38%, p < 0.0001), Medicaid insured (12.19% 6.97%, had 3 disease (7.05% 1.57%, (53.63% 46.90%, 0.0018). In adjusted analysis, odds developing than low (OR 1.281 95% CI 1.06–1.55). Moreover, 1-unit increase 10% 1.10, 1.04–1.16). There no statistically significant severity 1.02, 0.82–1.23). Conclusion this retrospective cohort survivors, Future research should elucidate pathways by which influences

Language: Английский

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Associations Between Social Determinants of Health, Allostatic Load, and Anthracycline Cardiotoxicity in a Diverse Patient Population

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Background Allostatic load (AL) is a measurement of physiological burden chronic stress, operationalized using composite score derived from biomarkers multiple physiologic systems. The relationship between AL and anthracycline cardiotoxicity unclear. Methods Results We included consecutive adult patients who underwent anthracycline‐based chemotherapy 2016 to 2019 for any type cancer. Patients with preexisting heart failure lack measures were excluded the analysis. A was calculated 9 tested before initiating chemotherapy. end point development (defined as clinical or drop in left ventricular ejection fraction≥10% <50%). total 718 analysis (29% Non‐Hispanic White, 31% Black, 40% Hispanic). mean 2.4±1.4 it significantly higher Black Hispanic compared White (2.5±1.3 versus 2.4±1.3 2.1±1.5 P =0.031). In developed cardiotoxicity, than without (2.7±1.4 2.3±1.3, =0.006). independently associated incident after adjusting race ethnicity, age, sex, cardiovascular risk factors, dose, baseline fraction, cancer type, metastasis (hazard ratio 1.20 per 1 increase [95% CI, 1.02–1.43], =0.033). remained additional adjustment social determinants health. Conclusions can be potential important prognostic marker prediction undergoing cardiotoxic treatment independent

Language: Английский

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Putting the health in hidden Markov models: incorporating allostatic load indices into movement ecology analyses

Conservation Physiology, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

Individual animal health assessments are a key consideration for conservation initiatives. Environmental shifts associated with climate change, such as documented rises in pathogen emergence, predation pressures and human activities, create an increasingly stressful world many species have been linked marked changes movement behaviour. Even healthy individuals, variations allostatic load, the cumulative effects of long-term stress, may alter behavioural priorities over time. Here, we aimed to build links between assessment information ecology, using narwhals Canadian Arctic case study. A composite stress index was developed incorporate multiple available (e.g. assessments), hormones) body condition metrics from clinically applied within framework widely used hidden Markov modelling data. Individuals higher tended prioritize behaviours indicative response, including increasing probability transitioning transiting behaviour compared those lower index. By incorporating that synthesizes indices flexible framework, highlight load be important explaining variation behaviour, even seemingly animals. The presented here highlights approach provides is applicable existing future work on range species.

Language: Английский

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