Anticancer Research,
Journal Year:
2024,
Volume and Issue:
44(8), P. 3375 - 3380
Published: July 26, 2024
Background/Aim:
Allostatic
load
(AL)
is
a
measure
of
chronic
stress
that
associated
with
worse
cancer
outcomes.
The
purpose
this
retrospective
cohort
study
was
to
investigate
the
relationship
between
AL
and
uveal
melanoma
(UM)
clinical
features.
Patients
Methods:
score
calculated
as
composite
ten
biomarkers
in
111
patients
UM
from
University
Illinois
Hospital.
One
point
assigned
an
for
each
biomarker
based
on
predetermined
cutoff
values.
Linear
logistic
regression
analyses
evaluated
several
tumor
characteristics.
Results:
High
had
significant
extraocular
extension
(p=0.015).
There
also
difference
mean
blood
glucose
levels
different
size
groups
(p=0.029).
Higher
scores
trend
being
smaller
(p=0.069).
Conclusion:
significantly
presence
melanoma,
while
smallest
group
highest
level.
No
other
correlations
were
found
features
UM.
warrants
further
investigation.
Additional
research
needed
evaluate
socioeconomic
factors
their
effect
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 8, 2024
Allostatic
load
(AL)
is
a
biological
measure
of
cumulative
exposure
to
socioenvironmental
stressors
(e.g.,
poverty).
This
study
aims
examine
the
association
between
allostatic
and
postoperative
complications
(POC)
among
patients
with
breast
cancer.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 18, 2024
Abstract
Background:
Cancer
remains
a
leading
cause
of
death
worldwide
and
continues
to
disproportionately
impact
certain
populations.
Several
frameworks
have
been
developed
that
illustrate
the
multiple
determinants
cancer.
Expanding
upon
work
others,
we
present
an
applied
framework
for
cancer
prevention
control
designed
help
clinicians,
as
well
public
health
practitioners
researchers,
better
address
differences
in
outcomes.
Methods:
The
was
by
Prevention
Control
Research
Network’s
Health
Behaviors
Workgroup.
An
initial
draft
based
on
workgroup
discussion,
theory,
rapid
literature
review
refined
through
interviews
focus
groups
with
Federally
Qualified
Center
providers
(
n
=2)
patients
=2);
participants
were
asked
provide
feedback
framework’s
causal
pathways,
completeness,
applicability
their
personal
life.
Results:
provides
overview
relationships
between
sociodemographic
inequalities,
social
structural
determinants,
key
risk
factors
associated
diagnosis,
survivorship,
morbidity
mortality
across
lifespan.
emphasizes
how
health-risk
behaviors
like
cigarette
smoking
interact
psychological,
psychosocial,
biological,
psychosocial
factors,
healthcare-related
behavior
other
chronic
diseases.
Importantly,
addressing
influence
reduce
burden
improve
equity.
Aligned
previous
our
underscores
importance
co-occurring
disease
states,
understanding
complex
cancer,
assessing
forms
inequality
or
disadvantage
intersect
increase
Conclusions:
This
paper
presents
differences.
Because
highlights
at
levels,
it
can
be
used
inform
development,
implementation,
evaluation
interventions
mortality.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 16, 2024
ABSTRACT
Breast
cancer
is
the
most
commonly
diagnosed
globally
and
leading
cause
of
death
in
women,
with
ethnic
disparities
reported
incidence,
prognosis,
diagnosis
therapeutic
response.
Although
precision
oncology
holds
promise
revolutionising
healthcare,
it
could
exacerbate
racial
seeks
to
eradicate
unless
rigorous
efforts
are
made
address
research
biases.
We
evaluated
molecular
clinical
effects
genetic
ancestry
African
South
Asian
women
using
a
combined
cohort
7,136
breast
patients
available
from
four
data
sources
–
100,000
Genomes
Project
(UK),
The
Cancer
Genome
Atlas
(US),
Now
Biobank
(London,
UK)
Genes
&
Health
(UK).
Using
assigned
European
as
baseline
comparator
for
all
analyses,
we
find
that
non-European
present
significantly
earlier
die
at
younger
age.
Patients
within
group
also
have
an
increased
prevalence
higher
grade
hormone
receptor
negative
disease.
show
small
tendency
towards
lower
stage
diagnosis,
tumour
mutational
burden.
observed
significant
differences
similarities
somatic
landscape
populations.
Six
genes,
RBM5
,
OTOF
FBXW7
NCKAP5
NOTCH3
GPR158
were
differentially
mutated
across
multiple
cohorts.
Furthermore,
potential
candidates
(
BRIP1,
CDKN2A,
CHEK2,
GPR158,
KDM6A,
RET,
STK11
)
found
be
and/or
groups.
germline
mutation
rates
identified
populations,
including
those
used
current
testing
(African:
TP53
BRCA1
BRCA2
PALB2
p<0.001;
Asian:
p<0.05)
well
implicated
predisposition
literature,
such
CDH1
CDK2A
ERCC3
EPCAM
FANCA
FANCC,
POLE
PMS2
.
There
propensity
BRCAness
population,
rate
serving
prognostic
indicator
into
response
therapies
PARP
inhibitors.
Our
study
confirms
under-representation
minority
groups
studies,
applications
biobanks,
none
resources
able
recapitulate
diversity
their
representative
geographical
locations
(UK,
London
US).
Finally,
our
findings
advocate
implementation
ancestry-specific
screening
windows
panels.
This
harnesses
multimodal
improve
understanding
ancestry-associated
highlight
opportunities
advance
health
equity
thus
taking
one
step
closer
achieving
equitable
oncology.
Anticancer Research,
Journal Year:
2024,
Volume and Issue:
44(8), P. 3375 - 3380
Published: July 26, 2024
Background/Aim:
Allostatic
load
(AL)
is
a
measure
of
chronic
stress
that
associated
with
worse
cancer
outcomes.
The
purpose
this
retrospective
cohort
study
was
to
investigate
the
relationship
between
AL
and
uveal
melanoma
(UM)
clinical
features.
Patients
Methods:
score
calculated
as
composite
ten
biomarkers
in
111
patients
UM
from
University
Illinois
Hospital.
One
point
assigned
an
for
each
biomarker
based
on
predetermined
cutoff
values.
Linear
logistic
regression
analyses
evaluated
several
tumor
characteristics.
Results:
High
had
significant
extraocular
extension
(p=0.015).
There
also
difference
mean
blood
glucose
levels
different
size
groups
(p=0.029).
Higher
scores
trend
being
smaller
(p=0.069).
Conclusion:
significantly
presence
melanoma,
while
smallest
group
highest
level.
No
other
correlations
were
found
features
UM.
warrants
further
investigation.
Additional
research
needed
evaluate
socioeconomic
factors
their
effect
