Systematic review and meta-analysis to estimate the burden of non-fatal and fatal overdose among people who inject drugs living in the U.S. and comparator countries: 2010 – 2023 DOI Open Access

Jalissa Shealey,

Eric W. Hall, Terri Pigott

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 20, 2024

Abstract Background People who inject drugs (PWID) have high risk for overdose, but there are no current estimates of overdose rates in this population. We estimated the non-fatal and fatal among PWID living U.S. comparator countries (Canada, Mexico, United Kingdom, Australia), ratios to using literature published 01/01/2010 – 09/29/2023. Methods PubMed, PsychInfo, Embase, ProQuest databases were systematically searched identify publications reporting prevalence or recent (past 12 months) non- PWID. Non-fatal meta-analyzed random effects models. Risk bias was assessed an adapted quality assessment tool, heterogeneity explored sensitivity analyses. Results Our review included 143 records, with 58 contributing unique data meta- analysis. 32.9 per 100 person- years (PY) (95% CI: 26.4 40.9; n=28) 1.7 PY 0.9 3.2; n=4), respectively. Limiting analysis collected after 2016 yielded a rate 41.0 32.1 52.5; n=16) 2.5 1.4 4.3; n=2) An 5% overdoses result death. Among analyzed countries, Australia had lowest largest ratio overdose. Conclusion Findings demonstrate substantial burden countries. Scale-up interventions that prevent mortality investments health research urgently needed.

Language: Английский

Endogenous opiates and behavior: 2023 DOI
Richard J. Bodnar

Peptides, Journal Year: 2024, Volume and Issue: 179, P. 171268 - 171268

Published: June 28, 2024

Language: Английский

Citations

5
Expanded access to intranasal naloxone and training among police officers in Western Australia: A pilot evaluation study DOI
Seraina Agramunt, Simon Lenton

Drug and Alcohol Review, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Abstract Introduction Naloxone has been recognised as a vital medicine in reducing opioid‐related deaths by reversing the effects of opioid overdose. This study evaluates effectiveness police naloxone administration pilot program Western Australia which officers were trained overdose management and administering intranasal naloxone. Based on similar programs other countries, this was first its kind Australia. Methods evaluation spanned July 2021–2022, involving pre‐ post‐training surveys an online follow‐up survey. A total 229 completed surveys, while 117 Data collected included questions about management, administration, training quality, access availability. Results There significant improvement officers' knowledge readiness to manage situations, particularly recognising signs symptoms overdose, factors increasing risk appropriate actions take such situations after training. Among who survey, 23 reported witnessing 16 having administered since their The positive impact further evident increased willingness administer when encountering Discussion conclusions findings demonstrate acceptability force emphasises life‐saving potential equipping with serves example for departments Australian jurisdictions roll out customised context beyond.

Language: Английский

Citations

0
Take-home naloxone in opioid dependency DOI
Simon Fleißner, Heino Stöver,

Dirk Schäffer

et al.

Deutsches Ärzteblatt international, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

There were 2227 drug-related deaths in Germany 2023, corresponding to a rise of 12% over the previous year and doubling course decade. Approximately 60% these related opioid consumption. In this narrative review, we discuss whether take-home naloxone (THN) might lower mortality persons with dependency. This review is based on pertinent publications that retrieved by selective search PubMed. Seven observational studies dependency included analysis. The available evidence for intervention low level. indicate an overall lowering even though significant reduction was not always achieved. It concluded meta-analysis 9 9.2% (95% confidence interval, [5.2; 13.1]) THN kits provided actually used first three months prevent overdose-related death. Canadian study, 43% [41; 45] handed out period 8 years successfully prevented latter figures suggest use may have been systematically underestimated date. Demonstrating efficacy difficult because nature research topic. Current implies lowers dependence. estimated only about 1.3% dependent people thus far. A major expansion provision could contribute further opioid-related deaths.

Language: Английский

Citations

0
Prevalence and incidence of emergency department presentations and hospital separations with injecting-related infections in a longitudinal cohort of people who inject drugs DOI Creative Commons
Stephanie J. Curtis, Samantha Colledge‐Frisby, Andrew J. Stewardson

et al.

Epidemiology and Infection, Journal Year: 2023, Volume and Issue: 151

Published: Jan. 1, 2023

People who inject drugs are at risk of acute bacterial and fungal injecting-related infections. There is evidence that incidence hospitalizations for infections increasing in several countries, but little known an individual level. We aimed to examine a linked longitudinal cohort people Melbourne, Australia. A retrospective descriptive analysis was conducted estimate the prevalence using administrative emergency department hospital separation datasets SuperMIX cohort, from 2008 2018. Over study period, 33% (95%CI: 31-36%) participants presented with any 27% 25-30%) were admitted hospital. Of 1,044 presentations 740 separations, skin soft tissue most common, 88% 76%, respectively. From 2018, there substantial increase separations infections, 48 135 per 1,000 person-years, 18 102 The results emphasize increasing, new models care needed help prevent facilitate early detection superficial infection avoid potentially life-threatening severe

Language: Английский

Citations

4
Perceptions of a Naloxone Leave Behind Program among Emergency Medical Services Personnel in Michigan, USA DOI Creative Commons
Jason B. Gibbons, Olivia K. Sugarman, Lauren Byrne

et al.

Drug and Alcohol Dependence Reports, Journal Year: 2024, Volume and Issue: 12, P. 100273 - 100273

Published: Aug. 14, 2024

In 2020, Michigan implemented its first Naloxone Leave-Behind Program for Emergency Medical Service (EMS) field providers. Under the program, EMS providers leave naloxone kits to individuals aged 15 or older they encounter in who have overdosed, indicate a substance use disorder, exhibit signs of opioid and/or bystanders, friends, family that are present at encounter.

Language: Английский

Citations

0
Systematic review and meta-analysis to estimate the burden of non-fatal and fatal overdose among people who inject drugs living in the U.S. and comparator countries: 2010 – 2023 DOI Open Access

Jalissa Shealey,

Eric W. Hall, Terri Pigott

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 20, 2024

Abstract Background People who inject drugs (PWID) have high risk for overdose, but there are no current estimates of overdose rates in this population. We estimated the non-fatal and fatal among PWID living U.S. comparator countries (Canada, Mexico, United Kingdom, Australia), ratios to using literature published 01/01/2010 – 09/29/2023. Methods PubMed, PsychInfo, Embase, ProQuest databases were systematically searched identify publications reporting prevalence or recent (past 12 months) non- PWID. Non-fatal meta-analyzed random effects models. Risk bias was assessed an adapted quality assessment tool, heterogeneity explored sensitivity analyses. Results Our review included 143 records, with 58 contributing unique data meta- analysis. 32.9 per 100 person- years (PY) (95% CI: 26.4 40.9; n=28) 1.7 PY 0.9 3.2; n=4), respectively. Limiting analysis collected after 2016 yielded a rate 41.0 32.1 52.5; n=16) 2.5 1.4 4.3; n=2) An 5% overdoses result death. Among analyzed countries, Australia had lowest largest ratio overdose. Conclusion Findings demonstrate substantial burden countries. Scale-up interventions that prevent mortality investments health research urgently needed.

Language: Английский

Citations

0