Study protocol for an observational cohort study of heat stress impacts in pregnancy in The Gambia, West Africa DOI Creative Commons
Ana Bonell, Leonidas G. Ioannou, Abdul Karim Sesay

et al.

Wellcome Open Research, Journal Year: 2024, Volume and Issue: 9, P. 624 - 624

Published: Oct. 28, 2024

Climate change has resulted in an increase heat exposure globally. There is strong evidence that this increased stress associated with poor maternal and fetal outcomes, especially vulnerable populations. However, there remains understanding of the biological pathways mechanisms involved impact pregnancy. This observational cohort study 764 pregnant participants based sub-Saharan Africa, a geographical region at risk extreme events, aims to evaluate physiological biochemical changes occur pregnancy due stress. The key objectives are 1) map understand what environmental, social community factors exposure; 2) assess on health, e.g. strain, subjective psychological well-being, sleep activity level; 3) how impacts placenta structure function; 4) determine chronic birth outcomes; 5) explore epigenetic infant by per trimester. Pregnant women will be recruited from two distinct regions Gambia exploit naturally occurring gradient across country. Microclimate mapping area recruitment give detailed measurements. Participants asked wear watch-style device 28- 35-weeks gestational age heart rate, sleep. At end week, ultrasound scan performed size placental blood flow. delivery, outcomes recorded maternal, cord samples taken for epigenetic, histological evaluation. Evaluation neuro-behaviour final 1 month following birth.

Language: Английский

Scoping Review of Climate Drivers on Maternal Health:Current Evidence and Clinical Implications DOI Creative Commons
Claire Masters, Chuhan Wu,

David Gleeson

et al.

AJOG Global Reports, Journal Year: 2025, Volume and Issue: 5(1), P. 100444 - 100444

Published: Jan. 18, 2025

To systematically review the literature on associations between climate drivers and health outcomes among pregnant people. This fills a gap by synthesizing evidence for clinician audience. Systematic scoping of articles published in PubMed clinicaltrials.gov from January 2010 through December 2023. Empirical studies English-language peer-reviewed journals, assessing select adverse maternal birth outcomes. The included examining heat, storms, sea level rise, flooding, drought, wildfires, other climate-related factors. Health preterm birth, low birthweight, small gestational age, diabetes, pre-eclampsia/eclampsia, miscarriage/stillbirth mortality. protocol was registered with International Platform Registered Review Meta-analysis Protocols (INPLASY202410004, 3, 2024) conducted accordance Preferred Reporting Items Reviews Meta-Analysis (PRISMA). Data were extracted 2 authors; quality risk bias assessed independently. Total 966 references screened; 16.35% (k=158) met inclusion criteria. majority (146/158; 92.4%) documented statistically significant clinically meaningful perinatal outcomes, including stillbirth as well preeclampsia, miscarriage, death. Among most durable findings: extreme heat exposure early late pregnancy associated increased stillbirth. Driven part large (often population-based) objective surveillance data or medical record reviews, this evaluated high (scoring 7-9 Newcastle-Ottawa Scale). Risk generally low. Climate are consistently Continuing education clinicians, clinician-patient communications should be expanded to address risks change weather exposure, especially late-pregnancy. Results inform multilevel interventions effects during practice advisories, protocols, checklists, clinical guidelines obstetrics.

Language: Английский

Citations

1
Heat exposure induced risks of preterm birth mediated by maternal hypertension DOI
Liyun Wang, Jiangli Di, Qiong Wang

et al.

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(7), P. 1974 - 1981

Published: May 15, 2024

Language: Английский

Citations

5
The Impact of Climate Change on Immunity and Gut Microbiota in the Development of Disease DOI Creative Commons
Pierluigi Rio, Mario Caldarelli, Antonio Gasbarrini

et al.

Diseases, Journal Year: 2024, Volume and Issue: 12(6), P. 118 - 118

Published: June 3, 2024

According to the definition provided by United Nations, “climate change” describes persistent alterations in temperatures and weather trends. These may arise naturally, such as fluctuations solar cycle. Nonetheless, since 19th century, human activities have emerged primary agent for climate change, primarily attributed combustion of fossil fuels coal, oil, gas. Climate change can potentially influence well-being, agricultural production, housing, safety, employment opportunities all individuals. The immune system is an important interface through which global affects health. Extreme heat, events environmental pollutants could impair both innate adaptive responses, promoting inflammation genomic instability, increasing risk autoimmune chronic inflammatory diseases. Moreover, has impact on soil gut microbiome composition, further explain changes health outcomes. This narrative review aims explore disease, focusing specifically its effects microbiota. Understanding how these factors contribute development physical mental illness allow design strategies aimed at reducing negative pollution

Language: Английский

Citations

5
The Independent and Cumulative Effects of Screen Exposure on Suicidal Ideation in Chinese Adolescents with Depressive Symptoms DOI

Xinran Xie,

Xiangyu Zhao,

Feng Zhuo

et al.

Journal of Pediatric Health Care, Journal Year: 2025, Volume and Issue: 39(2), P. 206 - 216

Published: Jan. 10, 2025

Language: Английский

Citations

0
Fine Particulate Matter, Its Constituents, and Spontaneous Preterm Birth DOI Creative Commons
Anqi Jiao,

Alexa N. Reilly,

Tarik Benmarhnia

et al.

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(11), P. e2444593 - e2444593

Published: Nov. 13, 2024

The associations of exposure to fine particulate matter (PM2.5) and its constituents with spontaneous preterm birth (sPTB) remain understudied. Identifying subpopulations at increased risk characterized by socioeconomic status other environmental factors is critical for targeted interventions.

Language: Английский

Citations

3
A scoping review of natural disasters, environmental hazards, and maternal health: Are all potential outcomes accounted for in conceptual frameworks? DOI Creative Commons

Claudia Schulte,

Blake Erhardt‐Ohren, Ndola Prata

et al.

PLOS Climate, Journal Year: 2025, Volume and Issue: 4(1), P. e0000558 - e0000558

Published: Jan. 10, 2025

Natural disasters and extreme weather events are increasing in frequency intensity, part due to climate change. These can have severe impacts, including on maternal health. We review the existing research natural disasters, environmental hazards, health outcomes – focusing specifically relevant conceptual frameworks termination of pregnancy as an outcome these published between January 2004 May 2024. retrieved eight 26 additional articles. None identified though there is ample evidence suggest that related must be included frameworks. propose a new, comprehensive framework which all reproductive with potential affect morbidity or mortality, (i.e., induced abortion), considered. hope N atural E nvironmental M aternal O utcomes (NEMO) will inform emergency response planning improve service delivery empowers individuals make informed choices wake crises.

Language: Английский

Citations

0
Mental health disparities among maternal populations following heatwave exposure in North Carolina (2011–2019): a matched analysis DOI Creative Commons

Sarah E Ulrich,

Margaret M. Sugg,

Dennis Guignet

et al.

The Lancet Regional Health - Americas, Journal Year: 2025, Volume and Issue: 42, P. 100998 - 100998

Published: Jan. 23, 2025

Language: Английский

Citations

0
Physical activity and heat stress shape water needs in pregnant endurance athletes DOI Creative Commons
Srishti Sadhir, Amanda McGrosky, Zane S. Swanson

et al.

Evolution Medicine and Public Health, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Pregnancy, heat stress, and physical activity (PA) are all known to independently increase human water requirements. We hypothesize that climate conditions behavioral strategies interact shape needs in highly active pregnancies. recruited 20 female endurance runners who were pregnant (8-16 weeks gestational age; n = 13) or planning be (n 7) for an observational, prospective cohort study. At three timepoints the study (preconception, 8-16 weeks, 32-35 weeks), we measured turnover (WT) using deuterium dilution elimination technique, PA ActiGraph wGT3X-BT accelerometers, index (HI) historical temperature humidity data. also compared athletes nonathletes from a previously published Athletes maintained high WT preconception through end of pregnancy. was positively associated with among early pregnancy time periods but not third trimester. HI weakly moderated relationship between predicting more positive slope hotter humid weather conditions. higher than nonathletes, this difference attenuated during trimester, as increased their WT. experience greater levels PA, is somewhat stronger With threat change expected exacerbate extreme conditions, evidence-based, global policies required particularly vulnerable populations.

Language: Английский

Citations

0
Study protocol for an observational cohort study of heat stress impacts in pregnancy in The Gambia, West Africa DOI Creative Commons
Ana Bonell, Leonidas G. Ioannou, Abdul Karim Sesay

et al.

Wellcome Open Research, Journal Year: 2025, Volume and Issue: 9, P. 624 - 624

Published: Feb. 7, 2025

Climate change has resulted in an increase heat exposure globally. There is strong evidence that this increased stress associated with poor maternal and fetal outcomes, especially vulnerable populations. However, there remains understanding of the biological pathways mechanisms involved impact pregnancy. This observational cohort study 764 pregnant participants based sub-Saharan Africa, a geographical region at risk extreme events, aims to evaluate physiological biochemical changes occur pregnancy due stress. The key objectives are 1) map understand what environmental, social community factors exposure; 2) assess on health, e.g. strain, subjective psychological well-being, sleep activity level; 3) how impacts placenta structure function; 4) determine chronic birth outcomes; 5) explore epigenetic infant by per trimester. Pregnant women will be recruited from two distinct regions Gambia exploit naturally occurring gradient across country. Microclimate mapping area recruitment give detailed measurements. Participants asked wear watch-style device 28- 35-weeks gestational age heart rate, sleep. At end week, ultrasound scan performed size placental blood flow. delivery, outcomes recorded maternal, cord samples taken for epigenetic, histological evaluation. Evaluation neuro-behaviour final 1 month following birth.

Language: Английский

Citations

0
Seasonal Influences on Human Placental Transcriptomes Associated with Spontaneous Preterm Birth DOI Creative Commons
Khondoker M. Akram,

Eleanor Dodd,

Dilly Anumba

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 303 - 303

Published: Feb. 18, 2025

Demographic studies have revealed a strong association between exposure to high ambient temperatures during pregnancy and increased risks of preterm birth (PTB). The mechanism underlying this is unclear, but it plausible that altered placental function may contribute it. In study, we conducted differential gene expression analysis, set enrichment analysis (GSEA), ontology (GO) on bulk RNA-seq data from human placentas delivered at term the warmer months compared colder in UK. We detected 48 differentially expressed genes months, majority which were inflammatory cytokines chemokines, including SERPINA1, IL1B, CCL3, CCL3L3, CCL4, CCL4L2, CCL20, CXCL8. GSEA positively enriched 17 signalling pathways, NF-κB, IL17, Toll-like receptor, chemokine pathways months. These results not observed same times year. GO several enhanced biological processes, neutrophil, granulocyte, monocyte, lymphocyte chemotaxis, as well humoral immune responses placentas, summer. conclude maternal warm environmental likely alters transcriptomes towards inflammation regulation, potentially leading PTB.

Language: Английский

Citations

0