NeuroToxicology, Journal Year: 2024, Volume and Issue: 105, P. 313 - 322
Published: Nov. 20, 2024
Language: Английский
Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 380(1918)
Published: Jan. 23, 2025
Chronobiology is a multidisciplinary field that extends across the tree of life, transcends all scales biological organization, and has huge translational potential. For UK to harness opportunities presented within applied chronobiology, we need build our network outwards reach stakeholders can directly benefit from discoveries. In this article, discuss importance rhythms health, society, economy environment, with particular focus on circadian rhythms. We subsequently introduce vision objectives BioClocks UK, newly formed research network, whose mission stimulate researcher interactions sustain discovery-impact cycles between chronobiologists, wider communities multiple industry sectors. This article part Theo Murphy meeting issue ‘Circadian in infection immunity’.
Language: Английский
Citations
1
Neurology, Journal Year: 2025, Volume and Issue: 104(8)
Published: March 19, 2025
Sleep disruptions are associated with cognitive aging in older adults. However, little is known about longitudinal sleep changes the oldest old and whether these linked to impairment. We aimed determine 24-hour multidimensional sleep-wake activity mild impairment (MCI) dementia women. studied cognitively unimpaired women enrolled Study of Osteoporotic Fractures who completed wrist actigraphy twice (baseline follow-up) had status evaluated at follow-up using a neuropsychological battery adjudication. To identify change profiles, we performed hierarchical clustering on principal components 5-year (median 5.0 [range 3.5-6.3] years) nighttime (sleep duration, efficiency [SE], wake after onset [WASO]), napping (duration frequency), circadian rest-activity rhythms (RARs; acrophase, amplitude, mesor, robustness). Using multinomial logistic regression, associations between profiles-and individual parameter changes-and MCI risk follow-up. Of 733 participants (mean age 82.5 ± 2.9 years), 164 (22.4%) developed 93 (12.7%) by visit. identified 3 profiles: stable (SS; n = 321 [43.8%]) was characterized stability or small improvements; declining (n 256 [34.9%]) showed decreases quality moderate increases, worsening RARs; increasing sleepiness (IS; 156 [21.3%]) exhibited large increases daytime duration quality, RARs. After adjustment for age, education, race, body mass index, diabetes, hypertension, myocardial infarction, antidepressant use, baseline cognition, IS approximately double (odds ratio 2.21, 95% CI 1.14-4.26) compared those SS. SE, WASO, nap frequency were individually dementia. Neither profiles nor parameters MCI. Among community-dwelling their 80s, over 5 years doubled during that time. Change may serve as an early marker factor
Language: Английский
Citations
1
Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1333 - 1333
Published: April 28, 2024
Background: Cognitive impairment (CI) is a common mental health disorder among older adults, and dietary patterns have an impact on cognitive function. However, no systematic researches constructed anti-inflammatory diet (AID) protein-enriched (PED) to explore their association with CI adults in China. Methods: The data used this study were obtained from the 2018 waves of China Longitudinal Health Longevity Survey (CLHLS). We construct AID, PED, calculate scores for CI. use binary logistic regression relationship between them, restrictive cubic splines determine whether relationships are non-linear. Subgroup analysis sensitivity demonstrate robustness results. Results: A total 8692 participants (mean age 83.53 years) included analysis. found that higher AID (OR = 0.789, 95% confidence interval: 0.740–0.842, p < 0.001) PED 0.910, 0.866–0.956, score showed lower odds suffering Besides, two linear, results subgroup also significant. Conclusion: Higher intakes associated risk which has important implications future prevention control nutritional perspective.
Language: Английский
Citations
6
Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 7, 2025
It has been demonstrated that older adults' cognitive capacities can be improved with sleep duration. However, the relationship between overweight, obesity, and decline remains a subject of debate. The impact duration on performance in seniors body mass index (BMI) ≥ 25 kg/m2 is largely unknown. This makes it an intriguing to explore further. study used data from National Health Nutrition Examination Survey (NHANES) (2011-2014) 2,243 participants. Weighted multivariate linear regression smooth curve fitting were employed investigate non-linear relationships. A two-part model was determine threshold effects. Additionally, subgroup analysis interaction tests conducted. Results showed negative association found scores fully adjusted Consortium Establish Registry for Alzheimer's Disease (CERAD) test, Animal Fluency test (AFT), Digit Symbol Substitution (DSST). two-piecewise then applied effect performance. When less than 5 6 h per day, positively correlated CERAD [ß (95% CI): 2.11 (1.17, 3.05), p < 0.0001], AFT [β 0.25 (-0.17, 0.67), = 0.2376], DSST 0.49 (-0.57, 1.56), 0.3654]. there where reached three inflection points. In overweight obese adults, clear inverted U-shaped function, consistent results across different subgroups. Sleep durations around 5-6 may help prevent adults BMI kg/m2.
Language: Английский
Citations
0
Environmental Research, Journal Year: 2025, Volume and Issue: 268, P. 120767 - 120767
Published: Jan. 7, 2025
Language: Английский
Citations
0
Sleep Health, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 16, 2025
Background Leisure activity and sleep time are key factors in cognitive impairment, but the impact of their long-term trajectories on incident impairment remains unclear. Objective To examine association leisure trajectories, combined effects with older adults. Methods Data from Chinese Longitudinal Healthy Longevity Survey (2008–2018) were analyzed, including adults aged ≥65 who participated at least three surveys. Group-based trajectory modeling explored patterns. Cox proportional-hazards regression model assessed impairment. Results We included 3094 participants a median follow-up 6.07 years. The optimal groups for four three, respectively. low-level group associated an increased risk (HR, 95%CI: 2.07, 1.37–3.13), whereas high-level reduced 0.60, 0.36–0.99). Short was 0.62, 0.41–0.92). In effect, belonging to moderate or long Conclusions Long-term short
Language: Английский
Citations
0
Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
Background The impact of sleep duration on cognition, particularly in the context poststroke cognitive impairment, is not fully understood. Therefore, our objective was to investigate how after stroke predicts impairment. Methods and Results Patients admitted with acute between 2015 2017 were consecutively recruited Nor‐COAST (Norwegian Cognitive Impairment After Stroke) study invited follow‐up assessments at 3 18 months. Time bed, used as a surrogate for months post stroke, measured using activPAL thigh‐worn sensor over 3‐day period. Sleep categorized into groups: <7 hours (insufficient), 7 9 (reference), ≥9 (excessive). impairment assessed based Diagnostic Statistical Manual Mental Disorders (Fifth Edition) criteria 3‐ 18‐month follow‐up. Out 815 patients, we included 443 (54%) prestroke healthy valid registration this analysis. Mean±SD age 71.2±11.4 years, 185 (42%) women, 363 (82%) had modified Rankin Scale score <2, 345 (78%) suffered minor (National Institutes Health Stroke ≤5). On average, participants spent 8.3±1.4 bed each night, 17.2% hours, 25% slept more than hours. Insufficient (odds ratio [OR], 3.6 [95% CI, 1.3–10.2], OR, 1.4 0.5–3.8]) excessive (OR, 2.8 1.1–7.5], 3.3 1.3–8.1]) associated an increased risk follow‐up, respectively. Conclusions or
Language: Английский
Citations
0
Frontiers in Network Physiology, Journal Year: 2024, Volume and Issue: 4
Published: Dec. 18, 2024
The Constrained Disorder Principle (CDP) defines all systems in nature by their degree of inherent variability. Per the CDP, intrinsic variability is mandatory for proper function and dynamically changed based on pressures. CDP boundaries as a mechanism continuous adaptation to internal external perturbations, enabling survival under dynamic conditions. laws govern world's natural phenomena underlie systems. Nevertheless, physics do not entirely explain systems' functionality pressure, which essential determining correct operation complex nature. Variability noise are two broad sources unpredictability biology technology. This paper explores how provides examples from various areas where applies, including climate, genetic, biology, human behavioral variabilities. According system malfunction results inappropriate performance environment influences physiological variability, species interactions influence eco-evolutionary outcomes. behavior being driven randomness accounts malfunctions corrections. reviews variability-based algorithms CDP-based second-generation artificial intelligence potential improving prediction efficiency using
Language: Английский
Citations
3
BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 22, 2025
Racial and ethnic disparities in sleep quality cognitive health are increasingly recognized, yet little is understood about their associations among Chinese older adults living the United States. This study aims to examine relationships between functioning this population, utilizing data from Population Study of Elderly Chicago (PINE). observational utilized a two-wave panel design as part PINE, including 2,228 participants aged 65 years or who self-identified Chinese. Participants completed interviews at two time points. Cognitive was assessed using battery tests, Mini-Mental State Examination (C_MMSE), immediate delayed recall East Boston Memory Test, Digit Span Backwards assessment, Symbol Modalities Test. Sleep items Pittsburgh Quality Index (PSQI), covering four aspects: subjective quality, latency, efficiency, duration. Insomnia Women's Health Initiative Rating Scale. Mixed-effects regression models were used assess effects parameters on baseline change over time. had an average age 77.42 (± 7.57) baseline, with 39% reporting fairly bad very quality. Poorer overall (B = -0.01, SE 0.01, p < .01), more insomnia symptoms 0.00, .001) associated lower global cognition. However, these diminished (sleep quality: B .05; insomnia: .05). Among subdomains, all except efficiency significantly negative The domains less consistent. findings highlight cross-sectional self-reported cognition, showing distinct various aspects domains. Targeted interventions improve may have potential enhance outcomes.
Language: Английский
Citations
0