Sex-Specific Obesity Paradox in Critically Ill Patients With Severe Acute Kidney Injury: A Retrospective Analysis DOI

Hyo Jin Jung,

Yu Jin Seo,

Jiyun Jung

et al.

Critical Care Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Objectives: Although obesity is typically correlated with adverse outcomes in various diseases, certain acute critical illnesses exhibit a phenomenon known as the paradox. This study evaluated sex-specific differences prognostic implications of body mass index (BMI) patients severe kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). Design: A multicenter retrospective cohort study. Setting: Data from eight tertiary hospitals Korea. PATIENTS: total 3805 critically ill receiving CRRT. Patients were categorized into four BMI groups: underweight, normal weight, overweight, and obese. Interventions: None. Measurements Main Results: There 2308 male 1497 female patients. The 90-day mortality risk significantly differed among groups overall patient population subpopulation but not subpopulation. Following adjustment for confounding variables, was higher underweight group than obese (hazard ratio [HR], 1.20; 95% CI, 1.05–1.36; p = 0.006). Among patients, both weight (underweight: HR, 1.30; 1.10–1.53; 0.002 weight: 1.18; 1.04–1.35; 0.010); however, no such association observed Subgroup analysis demonstrated paradox old age, septic AKI, or low albumin levels. Conclusions: sex between AKI. precise distribution fat muscle identified, had more favorable prognosis, which evident These findings highlight importance considering factors understanding complex relationship

Language: Английский

Risk Factors and Long-Term Outcomes of Acute Kidney Disease in Hematopoietic Stem Cell Transplant—Cohort Study DOI Open Access
Natacha Rodrigues, Carolina Branco,

Gonçalo Sousa

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 538 - 538

Published: Feb. 5, 2025

Background: Acute kidney disease (AKD) is a recent definition reflecting ongoing physiopathological processes of an acute renal injury (AKI). Information on AKD in hematopoietic stem cell transplant (HSCT) scarce and there no available data long-term outcomes. We aimed to determine the cumulative incidence first 100 days after HSCT; identify risk factors for impact 3-year overall survival relapse-free HSCT. Methods: A retrospective cohort study was conducted, considering when AKI present patient continued meet KDIGO criteria (creatinine and/or urinary output criteria) 7 or more. Survival analysis methods competing events were used disease-free survival, Cox proportional regression stepwise multivariable models. Results: enrolled 422 patients. 22.9% (95% CI: 19.2–27.4%). Higher body mass index (HR: 1.05, 95% CI 1.01–1.10; p = 0.034), HCT-CI score ≥ 2 1.83, 1.11–3.13; 0.027), allogeneic transplantation (HR:2.03, 1.26–3.33; 0.004), higher C-reactive protein (HR:1.01, 1.01–1.02; < 0.001), exposure nephrotoxic drugs 4.81, 1.54–4.95; 0.038) independently associated with AKD. had significant 1.75; 1.27–2.39; 0.001). Conclusion: An awareness allows identification high-risk patients, enabling timely implementation preventive measures alleviate progression disease.

Language: Английский

Citations

0
Impact of underweight status on mortality in sepsis patients: a meta-analysis DOI Creative Commons

Jiaan Chen,

Fan Zhang, Liang Li

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 6, 2025

The evidence regarding the impact of underweight status on clinical outcomes in patients with sepsis are still scarce and controversial. We aimed at conducting a meta-analysis to evaluate potential associations between mortality rate among patients. A comprehensive electronic search was performed PubMed, Cochrane Library, Embase, Web Science databases. Odds ratios (ORs) or mean differences 95% confidence intervals (CIs) were calculated using RevMan 5.3. total 58,348 (normal weight group: 49,084 patients; 9,264 patients) from 23 studies included this meta-analysis. results indicated that in-hospital (OR, 1.28; CI, 1.21, 1.35; heterogeneity: I 2 = 21%, P 0.21), 28-day 1.54; 1.26, 1.88; 74%, < 0.0001) 1-year 1.78; 1.58, 2.00; 41%, 0.17) significantly higher than those normal However, there no significant difference length hospital stay intensive care unit normal-weight Underweight is associated increased sepsis. Physicians should pay more attention management https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=631417, identifier CRD42025631417.

Language: Английский

Citations

0
Sepsis Associated Acute Kidney Injury DOI Creative Commons

Sohel Mohamed Gamal Ahmed,

Essam Mahmoud,

Malek Abusannuga

et al.

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Acute kidney injury (AKI) associated with sepsis is a critical medical condition characterised by sudden decrease of renal function as result an infection, particularly severe sepsis. Sepsis potentially fatal that arises from the immune system’s reaction to which involves release chemicals into circulation in effort combat infection; this results extensive inflammation throughout body. This may occasionally hinder optimal blood flow kidneys, resulting AKI. AKI can develop rapidly context and necessitates immediate attention. Laboratory tests are frequently used assess function, while radiological imaging detect any abnormalities. Antibiotics commonly prescribed treat underlying supportive care implemented maintain function. Patients conditions might require replacement modalities assist removal metabolites excess fluids bloodstream until recovers. Early diagnosis treatment sepsis, addition implementing strategies minimise complications essential for preventing treating sepsis-associated

Language: Английский

Citations

0
Association between pre-ICU statin use and acute kidney injury and in hospital mortality in obese patients with sepsis DOI

Xuanxuan Xiong,

Ye Liu

International Urology and Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Language: Английский

Citations

0
Disease trajectory and mortality among sepsis patients: a prospective cohort study DOI

Chunyang Li,

Chao Zhang, Bo Wang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Sepsis is a life-threatening disease and among the most common cause of death, which influence series following medical conditions. A comprehensive analysis cross-talks with temporary order trajectory or led to death sepsis remains unclear. By using data from population-based UK Biobank, 8647 septic patients matching 86386 controls without were included. Individuals followed-up 1 month after index date until end 2019 linkage inpatient records registers. Then conditional Cox regression, binomial test together logistic regression conducted visualize trajectories leading in survivors. During median follow-up 3.99 years, significantly increased risk 113 subsequent visualizing disease-disease associations time-dependent sequence, we identified four main affected clusters sepsis, including circulatory, metabolic, respiratory genitourinary system disease, further linking downstream health outcomes. We also mortality three major categories survivors, neoplastic, circulatory disease. In addition, differed gender age groups explored our study. These networks pathways broad range conditions provide potential intervention targeting these diseases for inhibiting adverse events patients.

Language: Английский

Citations

0
Development and Validation of a Nomogram for Predicting Acute Kidney Injury in Septic Patients DOI Creative Commons
Li Zhao, Tuo Zhang,

Xunliang Li

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 5653 - 5662

Published: Aug. 1, 2024

Sepsis-associated acute kidney injury (S-AKI) is associated with increased morbidity and mortality. We aimed to develop a nomogram for predicting the risk of S-AKI patients.

Language: Английский

Citations

0
CITED2 Mediates Metabolic Reprogramming in Renal Tubular Epithelial Cells via the AKT Signaling Pathway to Induce Sepsis-Associated Acute Kidney Injury DOI Creative Commons

Ruiming Deng,

Hang Yang,

Weibo Zhong

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 9485 - 9505

Published: Nov. 1, 2024

Sepsis-associated acute kidney injury (S-AKI) is a prevalent and severe clinical complication in intensive care units (ICUs) associated with high mortality poor prognosis. The dysfunction of renal tubular epithelial cells (TECs), particularly through their metabolic reprogramming, plays critical role the onset progression S-AKI. CITED2 shown to regulate variety cellular processes, but its specific impact on TECs metabolism S-AKI pathogenesis remains unclear. aim this study was investigate reprogramming effects inflammation C57BL/6 mouse model established using cecal ligation puncture (CLP). We assessed inflammatory responses, glucose expression kidneys septic mice. Additionally, effect evaluated vivo vitro models. silencing overexpression were employed elucidate regulatory role, focusing AKT signaling pathway. causes structural functional damage, aggravated dysregulated metabolism, accompanied by increased CITED2. attenuated reduced inflammation, thereby protecting from injury. Conversely, exacerbated dysfunction, promoted worsened Mechanistically, regulates TEC pathway, promoting S-AKI-related contributing drives aggravating response leading injury, highlighting Targeting inhibition may represent novel therapeutic approach for managing

Language: Английский

Citations

0
Sex-Specific Obesity Paradox in Critically Ill Patients With Severe Acute Kidney Injury: A Retrospective Analysis DOI

Hyo Jin Jung,

Yu Jin Seo,

Jiyun Jung

et al.

Critical Care Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Objectives: Although obesity is typically correlated with adverse outcomes in various diseases, certain acute critical illnesses exhibit a phenomenon known as the paradox. This study evaluated sex-specific differences prognostic implications of body mass index (BMI) patients severe kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). Design: A multicenter retrospective cohort study. Setting: Data from eight tertiary hospitals Korea. PATIENTS: total 3805 critically ill receiving CRRT. Patients were categorized into four BMI groups: underweight, normal weight, overweight, and obese. Interventions: None. Measurements Main Results: There 2308 male 1497 female patients. The 90-day mortality risk significantly differed among groups overall patient population subpopulation but not subpopulation. Following adjustment for confounding variables, was higher underweight group than obese (hazard ratio [HR], 1.20; 95% CI, 1.05–1.36; p = 0.006). Among patients, both weight (underweight: HR, 1.30; 1.10–1.53; 0.002 weight: 1.18; 1.04–1.35; 0.010); however, no such association observed Subgroup analysis demonstrated paradox old age, septic AKI, or low albumin levels. Conclusions: sex between AKI. precise distribution fat muscle identified, had more favorable prognosis, which evident These findings highlight importance considering factors understanding complex relationship

Language: Английский

Citations

0