Clinical Rheumatology, Journal Year: 2024, Volume and Issue: 43(10), P. 3073 - 3082
Published: Aug. 21, 2024
Language: Английский
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 23, 2025
The pace of aging varies between individuals and is marked by changes in DNA methylation (DNAm) including an increase randomness or entropy. Here, we computed epigenetic scores entropy using DNAm datasets from the Women's Health Initiative (WHI). We investigated how different metrics relate to demographic health variables, mortality risk. Income education, two proxies socioeconomics (SE), had consistent associations with Notably, stochastic increases at sites targeted polycomb proteins were significantly related both SE. While higher income was associated reduced age-related White women, protective effect diminished Black Hispanic on average, women relatively more aged epigenomes. Faster aging, as estimated DunedinPACE, predicted risk, while maintenance enhancer regions improved survival. Our findings demonstrate close ties social economic factors aspects suggesting potential biological mechanisms through which societal disparities may contribute differences outcomes lifespan across groups.
Language: Английский
Citations
0
Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Language: Английский
Citations
0
Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)
Published: April 9, 2025
Abstract Background DNA methylation-based predictors of phenotypic traits including leukocyte proportions, smoking activity, biological aging, and circulating levels plasma proteins are widely used as biomarkers in public health research. However, limited racial ethnic diversity research participants is an ongoing issue for epigenetics research, the potential downstream impacts training samples on performance epigenetic remains poorly understood. We examined chronological age (also known clocks), telomere length, cell within a diverse sample adult NHANES during 1999–2000 2001–2002 survey cycles, both overall stratified by self-reported race/ethnicity sex. utilized correlation coefficients median absolute errors (MAE) to judge predictor performance, bootstrapping multivariate regression assess significance differences between groups. Results All were significantly associated with their corresponding population, particularly high correlations clocks proportion estimates. Several significant observed racial/ethnic groups, protein predictors, reoccurring trend lower Mexican American non-Hispanic Black compared White participants. Sex-differences several also identified but not pronounced. Multivariate models indicated that disparities persisted after accounting predictions related sex, well further adjustment estimated proportions SES variables. Conclusions found evidence substantial each exhibiting at least one difference or MAE race, ethnicity,
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: March 17, 2024
Abstract This study is the first systematic meta-analysis of epigenetic age acceleration largest publicly available DNA methylation data for healthy samples (93 datasets, 23K samples), focusing on geographic and ethnic aspects different countries (25 countries) populations (31 ethnicities) around world. The most popular tools assessing were examined in detail, their quality metrics analyzed, ability to extrapolate from tissue types ranges training these models was explored. In cases, are not consistent with each other show signs acceleration, PhenoAge model tending systematically underestimate versions GrimAge overestimate prediction subjects. Although GEO open-access database, represented, datasets use criteria determining controls. Because this, it difficult fully isolate contribution “geography/environment”, “ethnicity” “healthiness” acceleration. However, DunedinPACE metric, which measures aging rate, adequately reflects standard living socioeconomic indicators countries, although can be applied only blood data. When comparing males faster than females considered.
Language: Английский
Citations
3
JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(7), P. e2421884 - e2421884
Published: July 29, 2024
Importance Disasters experienced by an entire community provide opportunities to understand individual differences in risk for adverse health outcomes over time. DNA methylation (DNAm) may help distinguish individuals at increased following large-scale disasters. Objective To examine the association of epigenetic age acceleration with probable posttraumatic stress disorder (PTSD) and PTSD symptom severity women. Design, Setting, Participants This prospective cohort study examined data from participants Women Their Children’s Health cohort, who were characterized longitudinally Deepwater Horizon oil spill (DHOS) 2010 through numerous hurricanes Gulf Coast region US. Wave 1 occurred August 6, 2012, June 26, 2014, wave 2 September 2, May 27, 2016. Data analyzed between 18 November 4, 2023. Address-based sampling was used recruit women aged 80 years residing 7 Louisiana parishes surrounding DHOS-affected region. Recruitment consisted 2-stage that (1) undersampled more urban maximize probability participant exposure (2) proportionally recruited across census tracts 5 other closest spill. Exposure Posttraumatic subsequent DHOS. Main Outcome Measures Epigenetic measured DNAm assayed survey blood samples. assessed using Checklist DSM-5 lifetime trauma Life Events . General linear models diagnosis severity. Results A total 864 (mean [SD] age, 47.1 [12.0] years; 328 Black [38.0%], 19 American Indian [2.2%], 486 White [56.3%], 30 racial groups, including uknown or unreported [3.5%]) included. had a higher compared (β = 1.64 [95% CI, 1.02-2.45] 2.34 0.33-4.34], respectively), they 7.10 4.62-9.58] 13.08 4.97-21.18], respectively). associated after adjusting race, smoking, body mass index, household income 0.38; 95% 0.11-0.65). Conclusions Relevance In this study, minoritized groups future These findings support need psychoeducation about traumatic responses increase likelihood treatment is sought before distress entrenchment symptoms comorbidities occur.
Language: Английский
Citations
3
JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(7), P. e2421841 - e2421841
Published: July 29, 2024
Importance Low childhood socioeconomic status (SES) is a social hallmark of aging that contributes to adult health disparities and earlier morbidity mortality. Childhood perceptions stress are associated with child outcomes may contribute premature biological into adulthood. Objective To describe the association SES perceived midlife insulin resistance epigenetic age explore whether late adolescent adiposity mediates observed associations. Design, Setting, Participants The longitudinal cohort National Heart, Lung, Blood Institute Growth Health Study enrolled girls aged 10 years from January 1987 May 1988, followed them up 19 age. Richmond, California, were recruited again at in 2016 assess Analyses conducted August 2, 2023, March 18, 2024. A total 433 participants eligible included analyses (specific sample sizes ranged across 303 391). Exposures levels (parental educational level income) 11 Main Outcomes Measures hypotheses tested formulated after data collection. homeostatic model assessment (HOMA-IR) GrimAge DunedinPACE clocks. Waist circumference adolescence was as mediator. Results Among participants, mean (SD) 39.4 (1.2) years; 218 (50.3%) Black 215 (49.7%) White; 135 (31.2%) had parents college degree or higher. Higher parental lower HOMA-IR (B = −0.22 [95% CI, −0.41 −0.02]; P .03), −1.76 −2.85 −0.66] .002), slower −0.03 −6.29 −0.002]; .04). indirectly through 0.01 0.001-0.01]; .02) 0.02 0.003-0.04] .01). Conclusions Relevance In this study aging, hallmarks (GrimAge DunedinPACE). Future studies should identify malleable factors slow impact aging.
Language: Английский
Citations
3
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: March 28, 2024
Abstract Marginalization due to structural racism may confer an increased risk for aging-related diseases – in part via effects on people’s mental health. Here we leverage a prospective birth cohort study examine whether the emergence of racial disparities health and DNA-methylation measures biological aging ( i . e ., DunedinPACE, GrimAge Acceleration, PhenoAge Acceleration) are linked across childhood adolescence. We further consider what extent statistically accounted by perinatal postnatal factors preregistered analyses N=4,898 participants from Future Families & Child Wellbeing Study, which N=2,039 had repeated saliva DNA methylation at ages 9 15 years. find that racially marginalized children higher levels externalizing internalizing behaviors diverging longitudinal slopes. Black compared White identifying children, living more segregated neighborhoods, affected colorism tended have age-9 age acceleration over Notably, increases behavior were correlated with aging. While ethnic largely socioeconomic variables, differences often still visible beyond covariate controls. Our findings indicate emerge early life. Programs promoting equity must address psychological physical impacts children. Comprehensive lacking current population cohorts.
Language: Английский
Citations
1
JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(9), P. e2435199 - e2435199
Published: Sept. 27, 2024
Importance Integrated health care systems have initiated major investments to identify and address social risks, particularly for patients with multiple medical conditions. Objective To evaluate the association of risks use among complex multimorbidity. Design, Setting, Participants This longitudinal cohort study assessed Kaiser Permanente Northern California (KPNC) (1) moderate complexity (defined by high comorbidity score, risk hospitalization, and/or prior emergency department [ED] admissions) (2) (eg, meeting additional criteria, such as ≥7 medications laboratory evidence poor disease control). Exposure Social requiring financial assistance self-reported barriers care). Main Outcomes Measures Inpatient outpatient during 12 months follow-up (January 15, 2023, January 14, 2024). Results The sample included 97 252 KPNC (mean [SD] age, 69.5 [16] years; 52.1% female; 10.6% Asian, 11.1% Black, 18.3% Hispanic, 54.6% White, 5.5% other race or ethnicity [eg, American Indian Alaskan Native, Native Hawaiian Pacific Islander, multiracial, unknown race]; 8.8% insured Medicaid), including 27 827 (5074 [18.2%] risks) 69 425 (17 343 [25.0%] risks). In fully adjusted models, complexity, were associated higher odds inpatient admissions (odds ratio [OR], 1.2; 95% CI, 1.1-1.4), ED visits (OR, 1.1-1.3), mental 1.1-1.3) vs individuals without risks. Among 1.1-1.2), 30-day readmissions 1.3; 1.2-1.3) Conclusions relevance this coexisting substantial downstream use. Efforts reduce in could include concurrent efforts
Language: Английский
Citations
1
Journal of Pain Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 4317 - 4329
Published: Dec. 1, 2024
Having a lower socioeconomic status (SES) is predictor of age-related chronic conditions, including low back pain (cLBP). We aimed to examine whether the pace biological aging mediates relationship between SES and cLBP outcomes - intensity, interference, physical performance.
Language: Английский
Citations
1
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: Nov. 5, 2023
Abstract Importance People who complete more education live longer lives with better health. New evidence suggests that these benefits operate through a slowed pace of biological aging. If so, measurements the aging could offer intermediate endpoints for studies how interventions to promote will impact healthy longevity. Objective To test hypothesis upward educational mobility contributes slower and increased Design Prospective cohort study. Setting We analyzed data from three generations participants in Framingham Heart Study: Original cohort, enrolled beginning 1948, Offspring 1971, Gen3 2002. Follow-up is on-going. Data analysis was conducted during 2022-2023 using obtained dbGaP (phs000007.v33). Participants constructed three-generation database quantify intergenerational mobility. linked blood DNA methylation collected (2005-2008) (n=1,652) 2009-2011 (n=1,449). These n=3,101 formed our sample. Exposure measured by comparing participants’ outcomes those their parents. Outcomes whole-blood DNA-methylation DunedinPACE epigenetic clock. For comparison purposes, we repeated four other clocks. Survival follow-up 2019. Results were upwardly mobile terms tended have later life (r=-0.18, 95% CI [-0.23,-0.13], p<0.001). This pattern association similar across held within-family sibling comparisons. 402 Offspring-cohort died over period. Upward associated lower mortality risk (HR=0.89, [0.81,0.98] p=0.014). Slower accounted roughly half this association. Conclusions Relevance Our findings support attainment slow Epigenetic clocks, like DunedinPACE, potential as near-term outcome measures intervention effects on Experimental needed confirm findings.
Language: Английский
Citations
2