Antenatal Opioid Exposure and Global and Regional Brain Volumes in Newborns
JAMA Pediatrics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 7, 2025
Importance
Although
antenatal
opioid
exposure
is
associated
with
impaired
brain
growth,
previous
studies
are
limited
by
small
sample
sizes
and
lack
of
controls.
As
a
result,
the
impacts
on
developing
remain
poorly
understood.
Objective
To
compare
global,
regional,
tissue-specific
volumes
in
opioid-exposed
newborns
vs
unexposed
Design,
Setting,
Participants
In
OBOE
(Outcomes
Babies
Opioid
Exposure)
study,
term
controls
were
recruited
at
4
sites
US
from
August
2020
to
December
2023.
Data
analysis
was
performed
2024.
Main
Outcomes
Measures
The
primary
outcome
both
groups,
assessed
via
unsedated
3-dimensional
(3-D)
volumetric
magnetic
resonance
imaging
(MRI)
prior
8
weeks
age.
T2-weighted
MRI
data
acquired
Siemens
Philips
3T
scanners
harmonized
across
sites.
Brains
segmented
using
DrawEM-
3D
U-Net–based
pipelines
manual
corrections.
Brain
compared
between
groups
covariance,
adjusting
for
postmenstrual
age
MRI,
sex,
birth
weight,
maternal
smoking,
education.
Results
A
total
173
96
studied.
MRIs
mean
(SD)
42.84
(2.11)
weeks,
117
(43.5%)
female.
group
had
significantly
smaller
volume
(387.51
407.06
cm
3
;
difference,
19.55;
95%
CI,
8.75-30.35)
cortical
(167.07
176.35
9.28;
3.86-14.70),
deep
gray
matter
(27.22
28.76
1.54;
0.66-2.43),
white
(159.90
166.65
6.76;
1.71-11.81),
cerebellar
(23.47
24.99
1.52;
0.67-2.36),
brainstem
(6.80
7.18
0.38;
0.19-0.57),
amygdala
(left:
0.48
0.51
0.03;
0.004-0.05;
right:
0.55
0.04;
0.08-0.07)
Methadone-exposed
showed
controls,
while
buprenorphine-exposed
right
than
Compared
exposed
opioids
only
those
plus
other
substances
significant
reductions
matter,
cerebellum,
brainstem,
amygdala,
brain.
Polysubstance-exposed
additionally
left
Conclusions
Relevance
large
cohort
antenatally
newborns,
there
global
regional
These
suggest
vulnerability
exposure,
varying
effects
depending
type
number
substances.
Trial
Registration
ClinicalTrials.gov
Identifier:
NCT04149509
Language: Английский
Functional Connectivity to the Amygdala in the Neonate Is Impacted by the Maternal Anxiety Level During Pregnancy
Trenesha L. Hill,
No information about this author
Xiaoxu Na,
No information about this author
Jayne Bellando
No information about this author
et al.
Journal of Neuroimaging,
Journal Year:
2025,
Volume and Issue:
35(1)
Published: Jan. 1, 2025
ABSTRACT
Background
and
Purpose
Anxiety
during
pregnancy
is
common,
exposure
to
heightened
anxiety
may
influence
children's
brain
development
functioning.
However,
it
unclear
if
low
levels
of
in
utero
would
also
impact
the
developing
brain.
The
current
prospective
longitudinal
study
included
40
healthy
pregnant
women
without
complications
or
previous
diagnosis
disorders.
Methods
Pregnant
women's
symptoms
were
measured
at
12,
24,
36
weeks
gestation.
Their
healthy,
full‐term
offspring
underwent
a
MRI
scan
sedation,
including
resting‐state
functional
MRI,
2
postnatal
age.
associations
between
neonatal
cortical
connectivity
originating
from
amygdala
maternal
prenatal
symptom
scores
examined
using
correlational
analyses.
Results
Significant
correlations
identified
after
controlling
for
child
sex,
postmenstrual
age
mother's
depression
scores.
Higher
was
related
alterations
offspring's
other
regions
involved
fear
learning.
Specifically,
higher
first
trimester
associated
with
lower
fusiform
gyrus
thalamus.
third
gyrus.
Conclusions
findings
this
indicate
that
functioning,
particularly
are
important
threat
detection.
Language: Английский
The Serbian version of the Pandemic-Related Pregnancy Stress Scale (PREPS-SRB)–A validation study
Konstantin Kostić,
No information about this author
A Kostić,
No information about this author
Aleksandra Petrović
No information about this author
et al.
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(2), P. e0317909 - e0317909
Published: Feb. 4, 2025
Pregnancy
is
a
sensitive
period
in
woman’s
life
when
psychological
distress
can
have
negative
consequences
for
the
mother
and
fetus.
Prolonged
intensified
symptoms
of
anxiety
depression
caused
by
COVID-19
pandemic
increase
risk
maternal
fetal
health
complications.
The
Pandemic-Related
Stress
Scale
(PREPS)
thoroughly
designed
tool
that
helps
determine
analyze
stress
among
pregnant
women
during
pandemics
three
domains:
Preparedness
childbirth,
(2)
Infection,
(3)
Positive
Appraisal.
A
cross-sectional
study
included
189
attending
community
center,
“Dr
Simo
Milošević,”
Belgrade,
Serbia,
from
January
to
February
2022.
Pregnant
anonymously
completed
questionnaire
as
part
study.
mean
scores
those
domains
are
follows:
(2.4
±
0.9),
Infection
(2.8
1.1),
Appraisal
(3.7
0.9).
Internal
consistency
PREPS
PREPS-Total
(α
=
0.867).
An
explanatory
factor
analysis
showed
Serbian
version
has
good
psychometric
properties.
Kaiser-Meyer-Olkin
Measure
Sampling
Adequacy
(KMO)
was
found
be
0.860,
indicating
high
degree
sampling
adequacy.
Additionally,
Bartlett’s
Test
Sphericity
yielded
statistically
significant
result
(χ
2
1564.206,
df
105,
p
<
0.001).
CFA
very
fit
indices
sample,
confirming
structure
original
English
version.
RMSEA
value
0.056
(0.036–0.075)
values
TLI
(0.961)
CFI
(0.974)
were
above
cut-off
≥0.95,
an
excellent
fit.
All
standardized
loadings
ranged
0.50
0.85.
PREPS-SRB
serves
valuable
healthcare
professionals,
allowing
them
identify
experiencing
related
pandemic.
Language: Английский
The role of prenatal stress and maternal trauma responses in predicting children’s mental health during war
European journal of psychotraumatology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 28, 2025
Background:
The
negative
effects
of
prenatal
stress
on
children's
development
and
the
buffering
maternal
behaviour
are
well
documented.
However,
specific
responses
to
trauma,
particularly
among
families
experiencing
cumulative
stressors
during
pregnancy
early
childhood,
remain
less
understood.
Language: Английский
Maternal psychological distress modifies the association between prenatal exposure to per- and polyfluoroalkyl substances and infants' neurodevelopment
The Science of The Total Environment,
Journal Year:
2025,
Volume and Issue:
977, P. 179351 - 179351
Published: April 10, 2025
Language: Английский
Evaluation of Spousal Support and Stress Coping Styles of Pregnant Women Diagnosed with Fetal Anomaly
S. Can,
No information about this author
Sevler Yıldız,
No information about this author
Ceren Sağlam
No information about this author
et al.
Medicina,
Journal Year:
2025,
Volume and Issue:
61(5), P. 868 - 868
Published: May 9, 2025
Background
and
Objectives:
Pregnant
women
may
experience
various
difficulties
when
abnormal
conditions
are
detected
in
their
babies.
We
examined
the
relationship
between
anxiety
depression
levels,
spousal
support,
stress-coping
styles
pregnant
diagnosed
with
fetal
anomalies.
Materials
Methods:
A
total
of
157
women,
59
whom
were
anomalies
98
healthy
no
obstetric
complications,
included
this
study.
All
participants
administered
Beck
Anxiety
Inventory
(BAI),
Depression
(BDI),
Spousal
Support
Scale
(SSS),
Coping
Styles
(CSS)
questionnaires.
The
data
compared
statistically.
Results:
BAI
(p
<
0.001)
Submissive
Approach
=
0.004),
which
is
a
subdimension
CSS,
significantly
higher
group
than
control
group.
Multivariate
logistic
regression
analysis
performed
to
calculate
risk
showed
that
having
high
school
education
or
below
living
city
associated
anomaly
countryside.
cut-off
value
4
for
had
sensitivity
64.4%
specificity
65.3.
Additionally,
6
Approach,
CSS
subdimension,
66.1%
57.1%
specificity.
significant
negative
correlation
was
observed
Scale,
BDI,
gravidity
case
There
positive
BDI
these
subdimensions:
Self-Confident
Seeking
Social
Support,
Optimistic
Approach.
Helpless
subdimensions,
as
well
gestational
age
at
detected.
while
correlations
subdimensions
Conclusions:
experienced
anxiety,
but
most
tended
use
submissive
coping
style
deal
stress,
partners
also
supported
them.
Language: Английский