Predicting intentions towards long-term antidepressant use in the management of people with depression in primary care: A longitudinal survey study

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0299676 - e0299676

Published: March 4, 2025

Over the last two decades, antidepressant prescribing in UK has increased considerably, due to an number of people staying on antidepressants for longer. Even when treatment is no longer clinically indicated, qualitative research suggests many continue a fear depressive relapse or withdrawal symptoms. The quantitative effects peoples' beliefs and attitudes towards long-term use remain relatively unexplored. To determine extent which are associated with intentions stop use; whether translate into actual discontinuation. A questionnaire survey formed main component embedded mixed-methods study. Twenty general practices posted questionnaires adults aged over 18 receiving continuous prescriptions years. Outcomes explanatory variables were determined using extended model Theory Planned Behaviour, conducting exploratory descriptive regression analyses. primary outcome was participants' discontinue antidepressants. secondary behaviour change by any dosage at six months. 277 surveyed from 20 practices, 10 years median duration. Mean scores intention subjective norms starting come off low, 85% participants declared that continuing their necessary. Prescribing outcomes retrieved 175 medical records months after they completed found 86% had not changed antidepressant, 9% reduced dose, only 1% discontinued 4% dose. All Behaviour constructs concerns intentions, more favourable stopping having strongest associations use. Given few taking antidepressants, patients should be made aware importance ongoing monitoring review care practitioners. This would promote discussion support attitudinal initiation tapering where appropriate.

Language: Английский

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The missing link? Pharmacists’ perspectives on discontinuation of long-term antidepressants: a qualitative study

Therapeutic Advances in Psychopharmacology, Journal Year: 2025, Volume and Issue: 15

Published: April 1, 2025

Background: Long-term use of antidepressant drugs is widespread despite guidelines recommending limited duration. General practitioners (GPs) play a central role in reviewing and discontinuing antidepressants, although they hesitate to initiate discussion about the long-term use. The potential pharmacists this process underexplored, their pharmaceutical expertise accessibility. Objectives: To explore community pharmacists’ perspectives on discontinuation barriers facilitators involvement process. Design: Qualitative study. Methods: Semi-structured interviews were conducted with 14 Belgian until data saturation. Interviews recorded, transcribed, thematically analyzed. Results: Four themes emerged. (1) “Antidepressants at pharmacy: persistent taboo” showed hesitancy discussions due societal stigma fear being perceived as nosy. (2) “Balancing risks vs benefits” highlights that primarily concerned relapse stable patients but recognized patient request from experiencing side effects may facilitate discontinuation. (3) “Is my role?,” viewed GPs primary decision-makers discontinuation, limiting supporting GP treatment decisions. Key for included GP’s decision stop motivated patient. Regular reviews by pharmacist could also (4) Optimizing role’ strong need collaboration, acknowledging optimize knowledge skills support Conclusion: Our study reveals pivotal process, make decisions, while see supportive, following doctor’s decision. However, faced significant including relapse, taboo, unclear responsibilities. More education, confidence building, better collaboration empower proactive role, improving

Language: Английский

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Potential deprescribing indications for antidepressants between 2012 and 2019: repeated cross-sectional analysis in two Scottish health boards

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 11, 2024

Language: Английский

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Addressing Bias and Improving Research on Gender and Racial Disparities in Hepatitis B Assessment and Treatment

Journal of Hepatology, Journal Year: 2024, Volume and Issue: 81(6), P. e279 - e280

Published: July 30, 2024

Language: Английский

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Enhancing the applicability and rigor of precision surgical techniques in laparoscopic hepatectomy

Digestive and Liver Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Hidden Costs: The Clinical and Research Pitfalls of Mistaking Antidepressant Withdrawal for Relapse

Psychotherapy and Psychosomatics, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 5

Published: Nov. 28, 2024

Language: Английский

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