Targeting lysophosphatidic acid ameliorates dyslipidemia in familial hypercholesterolemia DOI Creative Commons
Zhiyong Du, Yu Wang, Li Fan

et al.

Research, Journal Year: 2023, Volume and Issue: 8

Published: Feb. 27, 2023

Familial hypercholesterolemia (FH) is a lipoprotein disorder characterized by elevated plasma levels of low-density cholesterol (LDL-C) and an increased risk premature atherosclerotic cardiovascular disease. Recent evidences have shown that several glycerophospholipid species were markedly altered in experimental FH animals exhibited diverse bioactivities. Nevertheless, the profiles their associated biological implications human remain largely unknown. In this study, we sought to comprehensively delineate phenotypes investigate functional roles key FH-altered molecules on metabolism. Targeted analysis 328 metabolites was used profile differentiated alterations patients with homozygous (HoFH; n = 181), heterozygous (HeFH; 452), non-FH ( 382). Our findings revealed dominated spectrum involved lysophosphatidic acid (LPA) Among LPA features, palmitoyl-LPA (16:0) showed significant association clinical LDL-C total HoFH HeFH populations. Using metabolomic strategy murine model, demonstrated supplementation 16:0 LDL free/esterified exacerbated lesions. Conversely, inhibition autotaxin-mediated production significantly ameliorated dyslipidemia. Mechanistically, uncovered could disrupt hepatic homeostasis impairing excretion inhibiting primary bile synthesis. summary, our study offers novel insights into lipid metabolism posits targeting may represent promising therapeutic for reducing population.

Language: Английский

The association between vitamin E intake and remnant cholesterol, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in US adults: a cross-sectional study DOI Creative Commons
Yuxuan Wang, Hao Li, Zhihao Zhang

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 1, 2024

Language: Английский

Citations

6
Predicting Cardiovascular Disease and All-Cause Mortality Using the Lymphocyte-to-Monocyte Ratio: Insights from Explainable Machine Learning Models DOI Creative Commons

Jichao Wu,

Die Huang,

Jiefang Li

et al.

International Journal of Cardiology Cardiovascular Risk and Prevention, Journal Year: 2025, Volume and Issue: unknown, P. 200372 - 200372

Published: Jan. 1, 2025

Language: Английский

Citations

0
A targeted reformulation of safflower oil: Enhancing anti-inflammatory potential and market competitiveness through ω3 enrichment DOI
Roshayani Arshad, Jiawei Wan,

Tingyang Ai

et al.

Food Research International, Journal Year: 2025, Volume and Issue: 203, P. 115793 - 115793

Published: Jan. 29, 2025

Language: Английский

Citations

0
Delving into biomarkers and predictive modeling for CVD mortality: a 20-year cohort study DOI Creative Commons
Zhen Wu,

Abdullahi Mohamud Hilowle,

Zhou Ying

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 3, 2025

Accurate prediction of cardiovascular disease (CVD) mortality is essential for effective treatment decisions and risk management. Current models often lack comprehensive integration key biomarkers, limiting their predictive power. This study aims to develop a model CVD-related using machine learning-based feature selection algorithm assess its performance compared existing models. We analyzed data from cohort 4,882 adults recruited between 1999 2004, followed up 20 years. After applying the Boruta selection, biomarkers including NT-proBNP, cardiac troponins, homocysteine were identified as significant predictors CVD mortality. Predictive built these alongside demographic clinical variables. Model was evaluated concordance index (C-index), sensitivity, specificity, accuracy, with internal validation conducted through bootstrap sampling. Additionally, decision curve analysis (DCA) performed benefit. The combined model, incorporating both variables, demonstrated superior C-index 0.9205 (95% CI: 0.9129–0.9319), outperforming variables alone (C-index: 0.9030 0.8938–0.9147)) or 0.8659 0.8519–0.8826)). Cox regression further mortality, elevated AST/ALT, TyG, BUN, systolic blood pressure, protective factors such higher chloride iron levels. Nomogram construction DCA confirmed that provided substantial net benefit across various time points. lipid profiles, inflammatory markers significantly improves accuracy novel approach offers enhanced prognostication, potential optimization inclusion additional lifestyle data.

Language: Английский

Citations

0
Clonal hematopoiesis of indeterminate potential, health indicators, and risk of cardiovascular diseases among patients with diabetes: a prospective cohort study DOI Creative Commons

Ying Sun,

Yuefeng Yu,

Lingli Cai

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 13, 2025

Language: Английский

Citations

0
Remnant cholesterol, lipid ratios, and the severity of coronary artery lesions: a retrospective cohort study in patients with coronary heart disease DOI Creative Commons
Yu Li, Yumei Zhai, S Hu

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 10, 2025

Background Emerging genetic and observational evidence indicates that remnant cholesterol (RC) is a significant residual risk factor for cardiovascular diseases. However, there relative paucity of exploring the correlation among RC, lipid ratios, atherosclerotic lesion severity. This study aimed to investigate predictive value RC ratios alone or in combination severity coronary artery stenosis patients with heart disease (CHD). Methods The Gensini score was used assess lesions. CHD were categorized into mild moderate-to-severe groups. Logistic regression evaluate high associated ratios. Our also examined relationship between inconsistencies non-high-density lipoprotein (non-HDL-C) levels stenosis. Receiver operating characteristic (ROC) curves power moderate severe Results Multivariate models suggested strong predictor [odds ratio (OR): 5.44, P < 0.001]. When grouped by curve-fitting inflection points, group inconsistent RC/low non-HDL-C, rather than low RC/high non-HDL-C group, an increased compared consistent (OR: 2.72, 0.001). ROC showed predicted area under curve (AUC) 0.715 severity, improving efficacy combined predictors comprising (AUC: 0.723 vs. 0.703, 0.05). Conclusions various [triglyceride/HDL-C, total cholesterol/HDL-C, low-density apoloprotein (apo)B/apoA] correlated degree CHD, suggesting has potential as biomarker reflecting independent traditional factors non-HDL-C. could enhance based on model had better

Language: Английский

Citations

0
Changes in non-high-density lipoprotein to high-density lipoprotein ratio (NHHR) and cardiovascular disease: insights from CHARLS DOI Creative Commons

Bingxue Wang,

Liying Li, Ying Tang

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 25, 2025

The established association between the non-high-density lipoprotein cholesterol to high-density ratio (NHHR) and cardiovascular disease (CVD) risk has been well-documented. Nevertheless, relationship changes in NHHR CVD events remains be elucidated. present study aims clarify correlation change patterns incidence of across a broad population. current recruited participants from China Health Retirement Longitudinal Study (CHARLS). index was calculated using formula: = (TC-HDL-c)/HDL-c. Temporal were assessed with latent profile analysis, cumulative also evaluated. Multivariable Cox proportional hazards regression models multivariate-adjusted restricted cubic spline (RCS) analyses employed examine incident CVD. A total 4,629 individuals for study. average age 57.47 years, 53.7% being female. Over follow-up period, 879 cases documented. Compared lowest tertile, those highest tertile both baseline exhibited significantly increased CVD, adjusted hazard ratios (HRs) 1.43 (95% confidence interval [CI]: 1.21–1.70) 1.45 CI: 1.23–1.72), respectively. Participants classified Class 2 demonstrated 27% higher while 3 showed 41% greater compared 1 group. Further analysis revealed that this linear. Stratified corroborated primary findings. Baseline NHHR, are associated an among aged 45 years older, thereby confirming their potential as valuable tools stratification

Language: Английский

Citations

0
Global cardiovascular disease burden attributable to high low-density lipoprotein cholesterol, 1990-2021: an age-period-cohort analysis of the Global Burden of Disease Study 2021 DOI
Yangyu Zhao, Lei Chen,

Jiayang Dong

et al.

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 104030 - 104030

Published: March 1, 2025

Language: Английский

Citations

0
Clinical characteristics and mortality risk factors in pediatric hypertrophic, restrictive, and rapidly progressive hypertrophic cardiomyopathy: a retrospective cohort study with follow-up DOI Creative Commons
Asad Nawaz,

Zhaoxue Sheng,

Muhammad Junaid Akram

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 31, 2025

Background Pediatric cardiomyopathies are rare but life-threatening conditions with high mortality. Limited data exists on their clinical features and risk factors, especially in Asian populations, highlighting the need for further research this area. Methods This retrospective cohort study analyzed from 212 pediatric patients diagnosed hypertrophic cardiomyopathy (HCM), restrictive (RCM), or phenotype (RP-HCM) at a single center China October 2012 to 2023, follow-up until 31, 2024. Demographic, clinical, diagnostic data, as well outcomes, were reviewed. Logistic Cox regression models identified factors in-hospital long-term Results Among patients, 79.72% (169/212) had HCM, 16.98% (36/212) RCM, 3.30% (7/212) RP-HCM. Infection (75.47%, 160/212) heart failure (51.42%, 109/212) common comorbidities. In-hospital mortality was 5.19% (11/212), of 20.28% (43/212). The independent included left ventricular ejection fraction (LVEF), pulmonary hypertension, low-density lipoprotein (LDL) levels ( P < 0.05). Patients RP-HCM showed poorest rate 42.86%. Only 10.4% (22/212) underwent genetic testing, yet positive detection 63.7% (14/22). Conclusions underscores importance early diagnosis, integrated management cardiomyopathies. LVEF, LDL critical prognostic offering insights assessment affected children.

Language: Английский

Citations

0
Beneficial influence of low-density lipoprotein cholesterol on the endothelium in relation to endothelial repair DOI Creative Commons
Yūji Shimizu, Shin‐ya Kawashiri, Hirotomo Yamanashi

et al.

Environmental Health and Preventive Medicine, Journal Year: 2025, Volume and Issue: 30(0), P. 24 - 24

Published: Jan. 1, 2025

Low-density lipoprotein cholesterol (LDLc) is regarded as a risk factor for endothelial dysfunction. However, LDLc stimulates the proliferation of hematopoietic stem cells (CD34-positive cells), which contribute to repair. Therefore, may have beneficial influence on endothelium individuals with lower repair activity. This cross-sectional study included 245 men aged 60-69 years. Endothelial activity was categorized by circulating levels CD34-positive based median values. The status evaluated using cardio-ankle vascular index (CAVI). Among low cells, LDL-c were significantly inversely correlated CAVI and positively cells. No significant correlations observed among participants high adjusted standardized parameter (β) p value -0.24 (p = 0.021) 0.41 < 0.001) whereas corresponding values 0.03 0.738) -0.09 0.355). has health activity, possibly stimulating

Language: Английский

Citations

0