IGF-1 as a Biomarker for Symptom Severity in Adult Traumatic Brain Injury: Evidence from an Observational Study
Justin Weppner,
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Kimberly Rosenthal,
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Jennifer Bath
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et al.
Neurotrauma Reports,
Journal Year:
2025,
Volume and Issue:
6(1), P. 345 - 354
Published: Jan. 1, 2025
Language: Английский
Somatic Symptom Disorder After Mild Traumatic Brain Injury
Noah D. Silverberg,
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Mathilde Rioux,
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Ana Mikolić
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et al.
Journal of Head Trauma Rehabilitation,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 9, 2025
Objective:
Mild
traumatic
brain
injury
(mTBI)
may
be
a
common
precipitant
of
Somatic
Symptom
Disorder
(SSD).
This
study
examined
the
prevalence,
correlates,
predictors,
and
functional
impact
SSD
after
mTBI.
Setting:
Follow
up
patients
recruited
from
emergency
departments
urgent
care
centers.
Participants:
Adults
with
mTBI
(N
=
476).
Design:
Secondary
analysis
clinical
trial
(Clinicaltrials.gov
NCT04704037).
Main
Measures:
Early
illness
beliefs
(Illness
Perceptions
Questionnaire-Revised;
IPQ-R)
were
assessed
~2
weeks
outcomes
at
6
months
post-injury,
including
symptoms
(Somatic
Disorder-B
Criteria
Scale;
SSD-12),
post-concussion
(Rivermead
Post
Concussion
Symptoms
Questionnaire;
RPQ),
disability
(World
Health
Organization
Disability
Assessment
Schedule;
WHODAS),
psychiatric
diagnoses
(MINI
Neuropsychiatric
Inventory).
diagnosis
was
operationalized
as
having
persistent
SSD-12
≥
16
(≥23
in
sensitivity
analyses).
Results:
15-27%
sample
met
criteria
for
post-injury.
Participants
reported
more
pain
symptoms,
likely
to
have
comorbid
Major
Depressive
(OR
9.1,
95%
CI
5.3,
16.2)
least
1
anxiety
disorder
5.6,
3.6-8.8)
compared
those
without
SSD.
beliefs,
specifically
that
has
serious
life
consequences
1.2,
1.1-1.3)
causes
distress
1.1,
1.0-1.2),
associated
later
contributed
prediction
global
(WHODAS)
over
above
symptom
severity
(RPQ;
ΔDeviance
0.22,
P
<
.001).
Conclusions:
is
an
increased
burden
comorbidity,
disability.
identification
at-risk
appears
feasible.
useful
framework
conceptualizing
poor
outcome
prominent
psychological
guiding
rehabilitation.
Language: Английский
The relationship between prognostic factors and patient satisfaction with performance of self-identified goals following interdisciplinary mild traumatic brain injury rehabilitation
Physiotherapy Theory and Practice,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 9
Published: Sept. 11, 2024
Individuals
with
persistent
symptoms
following
a
mild
traumatic
brain
injury
(mTBI)
demonstrate
improved
satisfaction
their
performance
of
self-identified
rehabilitation
goals
after
completing
combined
occupational
therapy
and
physiotherapy
group
intervention.
However,
the
relationship
between
factors
associated
developing
an
mTBI
intervention
are
unknown.
Language: Английский
Real‐world efficacy of transfusion with liberal or restrictive strategy in traumatic brain injury
Liangwen Cui,
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Nian Liu,
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Chao Yu
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et al.
Annals of Clinical and Translational Neurology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 27, 2024
Abstract
Objective
The
short‐term
efficacy
of
red
blood
cell
(RBC)
transfusion
among
general
traumatic
brain
injury
(TBI)
patients
is
unclear.
Methods
We
used
the
MIMIC
database
to
compare
liberal
(10
g/dL)
versus
conservative
(7
strategy
in
TBI
patients.
outcomes
were
neurological
progression
(decrease
Glasgow
coma
scale
(GCS)
at
least
2
points)
and
death
within
28
days
ICU
admission.
Each
eligible
individual
was
cloned
assigned
each
replicates
one
treatment
arm.
imbalance
induced
by
informative
censoring
adjusted
inverse
probability
weighting.
standardized,
weighted
pooled
logistic
regression
with
500
bootstrap
resampling
estimate
cumulative
risk
difference
95%
confidence
interval
(CI).
Results
Of
1141
individuals,
29.0%
received
RBC
transfusion.
Compared
restrictive
group,
reduced
early
(3
days:
5%,
CI:
2%–7%;
7
6%,
3%–11%);
however,
no
significant
mortality
28‐day
or
any
time
points
observed.
coagulopathy
3
increased
7%
(95%
1%–19%)
group.
subgroup
analysis
indicated
a
beneficial
effect
on
hemodynamically
unstable
Interpretation
strategy,
does
not
improve
prognosis
real‐world
situation.
may
be
survival
very
stage
subgroup.
Language: Английский