Real‐world efficacy of transfusion with liberal or restrictive strategy in traumatic brain injury DOI Creative Commons

Liangwen Cui,

Nian Liu, Chao Yu

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Abstract Objective The short‐term efficacy of red blood cell (RBC) transfusion among general traumatic brain injury (TBI) patients is unclear. Methods We used the MIMIC database to compare liberal (10 g/dL) versus conservative (7 strategy in TBI patients. outcomes were neurological progression (decrease Glasgow coma scale (GCS) at least 2 points) and death within 28 days ICU admission. Each eligible individual was cloned assigned each replicates one treatment arm. imbalance induced by informative censoring adjusted inverse probability weighting. standardized, weighted pooled logistic regression with 500 bootstrap resampling estimate cumulative risk difference 95% confidence interval (CI). Results Of 1141 individuals, 29.0% received RBC transfusion. Compared restrictive group, reduced early (3 days: 5%, CI: 2%–7%; 7 6%, 3%–11%); however, no significant mortality 28‐day or any time points observed. coagulopathy 3 increased 7% (95% 1%–19%) group. subgroup analysis indicated a beneficial effect on hemodynamically unstable Interpretation strategy, does not improve prognosis real‐world situation. may be survival very stage subgroup.

Language: Английский

IGF-1 as a Biomarker for Symptom Severity in Adult Traumatic Brain Injury: Evidence from an Observational Study DOI Creative Commons
Justin Weppner,

Kimberly Rosenthal,

Jennifer Bath

et al.

Neurotrauma Reports, Journal Year: 2025, Volume and Issue: 6(1), P. 345 - 354

Published: Jan. 1, 2025

Language: Английский

Citations

0
Somatic Symptom Disorder After Mild Traumatic Brain Injury DOI
Noah D. Silverberg,

Mathilde Rioux,

Ana Mikolić

et al.

Journal of Head Trauma Rehabilitation, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Objective: Mild traumatic brain injury (mTBI) may be a common precipitant of Somatic Symptom Disorder (SSD). This study examined the prevalence, correlates, predictors, and functional impact SSD after mTBI. Setting: Follow up patients recruited from emergency departments urgent care centers. Participants: Adults with mTBI (N = 476). Design: Secondary analysis clinical trial (Clinicaltrials.gov NCT04704037). Main Measures: Early illness beliefs (Illness Perceptions Questionnaire-Revised; IPQ-R) were assessed ~2 weeks outcomes at 6 months post-injury, including symptoms (Somatic Disorder-B Criteria Scale; SSD-12), post-concussion (Rivermead Post Concussion Symptoms Questionnaire; RPQ), disability (World Health Organization Disability Assessment Schedule; WHODAS), psychiatric diagnoses (MINI Neuropsychiatric Inventory). diagnosis was operationalized as having persistent SSD-12 ≥ 16 (≥23 in sensitivity analyses). Results: 15-27% sample met criteria for post-injury. Participants reported more pain symptoms, likely to have comorbid Major Depressive (OR 9.1, 95% CI 5.3, 16.2) least 1 anxiety disorder 5.6, 3.6-8.8) compared those without SSD. beliefs, specifically that has serious life consequences 1.2, 1.1-1.3) causes distress 1.1, 1.0-1.2), associated later contributed prediction global (WHODAS) over above symptom severity (RPQ; ΔDeviance 0.22, P < .001). Conclusions: is an increased burden comorbidity, disability. identification at-risk appears feasible. useful framework conceptualizing poor outcome prominent psychological guiding rehabilitation.

Language: Английский

Citations

0
The relationship between prognostic factors and patient satisfaction with performance of self-identified goals following interdisciplinary mild traumatic brain injury rehabilitation DOI
Marquise M. Bonn, James P. Dickey,

Becky Moran

et al.

Physiotherapy Theory and Practice, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Sept. 11, 2024

Individuals with persistent symptoms following a mild traumatic brain injury (mTBI) demonstrate improved satisfaction their performance of self-identified rehabilitation goals after completing combined occupational therapy and physiotherapy group intervention. However, the relationship between factors associated developing an mTBI intervention are unknown.

Language: Английский

Citations

1
Real‐world efficacy of transfusion with liberal or restrictive strategy in traumatic brain injury DOI Creative Commons

Liangwen Cui,

Nian Liu, Chao Yu

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Abstract Objective The short‐term efficacy of red blood cell (RBC) transfusion among general traumatic brain injury (TBI) patients is unclear. Methods We used the MIMIC database to compare liberal (10 g/dL) versus conservative (7 strategy in TBI patients. outcomes were neurological progression (decrease Glasgow coma scale (GCS) at least 2 points) and death within 28 days ICU admission. Each eligible individual was cloned assigned each replicates one treatment arm. imbalance induced by informative censoring adjusted inverse probability weighting. standardized, weighted pooled logistic regression with 500 bootstrap resampling estimate cumulative risk difference 95% confidence interval (CI). Results Of 1141 individuals, 29.0% received RBC transfusion. Compared restrictive group, reduced early (3 days: 5%, CI: 2%–7%; 7 6%, 3%–11%); however, no significant mortality 28‐day or any time points observed. coagulopathy 3 increased 7% (95% 1%–19%) group. subgroup analysis indicated a beneficial effect on hemodynamically unstable Interpretation strategy, does not improve prognosis real‐world situation. may be survival very stage subgroup.

Language: Английский

Citations

0