The Perceptions of and Attitudes Toward Obesity in Bulgarian Adults with a BMI ≥ 25.0 kg/m2—An Exploratory Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 373 - 373

Published: Jan. 21, 2025

Background: Obesity affects 33.2% of the adult population in Bulgaria, and there is a scarcity information about affected individuals’ attitudes toward their weight situation. The aim this study was to explore perceptions obesity adults. Methods: present involved questionnaire-based survey that utilized home-based tablet-assisted face-to-face interviews. Interviewees comprised individuals aged 25–64 y/o with BMI > 25.0 kg/m2. Results: Overall, 704 respondents participated (344 overweight; 360 obese). Over 50% participants reported attempts reduce weight, only 6% overweight group 16% obese perceiving condition as worrisome. One-third considered state temporary. main cause for alarm overweight/obese worsening overall physical males an increase clothes size females. need urgent reduction body noted by 12% 40% respondents. reasons being were collated lack activity (noted 52% participants), sedentary lifestyle (51%), stress/depression (41%), excessive consumption carbohydrates (34%), general overconsumption food (33%), poor quality products (28%). Of note, 56% had first consulted medical professional overweight. Most selected dieting without reduction, 48% stating they would try drugs approved reduction. Conclusions: Many have unrealistic self-perception very low motivation take active measures. These discrepancies offer great opportunities better public education structured, strategies.

Language: Английский

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Estimation of total mediation effect for a binary trait in a case-control study for high-dimensional omics mediators

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Abstract Mediation analysis helps uncover how exposures impact outcomes through intermediate variables. Traditional mean-based total mediation effect measures can suffer from the cancellation of opposite component-wise effects and existing methods often lack power to capture weak in high-dimensional mediators. Additionally, most work has focused on continuous outcomes, with limited attention binary particularly case-control studies. To fill this gap, we propose an R 2 measure under liability framework, providing a causal interpretation applicable various models. We develop cross-fitted, modified Haseman-Elston regression-based estimation procedure tailored for studies, which also be applied cohort studies reduced efficiency. Our estimator remains consistent non-mediators sizes extensive simulations. Theoretical justification consistency is provided mild conditions. In Women’s Health Initiative 2150 individuals, found that 89% (CI: 73% 91%) variation underlying coronary heart disease associated BMI explained by metabolomics.

Language: Английский

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Global, regional and national burden of ischaemic heart disease attributable to high body mass index and low physical activity from 1990 to 2021

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Aim This study aimed to estimate the distribution of and changes in global burden ischaemic heart disease (IHD) attributable high body mass index (BMI) low physical activity (PA) from 1990 2021. Methods Data on deaths, disability‐adjusted life years (DALYs) age‐standardized rates for IHD BMI PA were extracted Global Burden Disease 2021 study. Temporal trends by gender, region Socio‐Demographic Index (SDI) analysed using joinpoint regression. Decomposition, health inequality analysis Bayesian model utilized. Results From 2021, DALYs deaths nearly doubled, despite a decline ([average annual percent change (AAPC) = −0.26, 95% uncertainty interval (95% UI): −0.45, −0.07), (AAPC −1.03, UI:−1.18, −0.88]) ([AAPC −0.53, UI: −0.72, −0.33], [AAPC −1.13,95% −1.34, −0.92]), respectively. The due was predominantly seen males, while more prevalent females. Significant regional national variation observed, with shifting SDI regions middle or regions. Population growth aging have exacerbated this burden. Health inequities shown improvement between Projections next 15 suggest rising death BMI, those may decrease. Conclusions Since 1990, impact remains significant, disparities age, SDI. Countries should implement effective measures control promote reduce

Language: Английский

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Prolonged Hospital Stay in Hypertensive Patients: Retrospective Analysis of Risk Factors and Interactions

Nursing Reports, Journal Year: 2025, Volume and Issue: 15(3), P. 110 - 110

Published: March 19, 2025

Background/Objectives: Arterial hypertension (HT) is a leading modifiable risk factor for cardiovascular diseases, often contributing to prolonged lengths of hospital stay (LOHS), which place significant strain on healthcare systems. This study aimed analyze the factors associated with in patients HT, focusing key biochemical and clinical predictors. Methods: retrospective included 356 adult hospitalized Cardiology Department University Hospital Wroclaw, Poland, between January 2017 June 2021. Data collected demographic characteristics, body mass index (BMI), comorbidities, laboratory parameters. Logistic regression models were used identify predictors LOHS, defined as four or more days, evaluate interactions variables. Results: Lower levels low-density lipoprotein cholesterol (LDL-c) elevated concentrations high-sensitivity C-reactive protein (hsCRP) identified each 1 mg/dL decrease LDL-c increasing odds LOHS by 1.21% (p < 0.001) mg/L increase hsCRP raising 3.80% = 0.004). An interaction sex heart failure (HF) was also observed. Female HF had 3.995-fold higher compared females without 0.001), while no difference found among male 0.890). Conclusions: The HT include lower LDL-c, hsCRP, (HF). Specifically, female demonstrated significantly HF, this relationship not observed patients.

Language: Английский

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The Relationship Between Biological Noise and Its Application: Understanding System Failures and Suggesting a Method to Enhance Functionality Based on the Constrained Disorder Principle

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 349 - 349

Published: March 27, 2025

The Constrained Disorder Principle (CDP) offers a new framework for understanding how biological systems use and manage noise to maintain optimal functionality. This review explores the relationship between at various scales, including genetic, cellular, organ levels, its implications system malfunctions. According CDP, all require an range of function appropriately, disease states can arise when these levels are disrupted. presents evidence supporting this principle across different contexts, such as genetic variability, cellular behavior, brain functions, human aging, evolution, drug administration. For accurate clinical assessments, it is essential distinguish technical variability intrinsic variability. When adequately constrained, serves fundamental mechanism adaptation functioning rather than simply source disruption. These findings have important developing more effective therapeutic strategies systems’ dynamics. CDP-based second-generation artificial intelligence help regulate address improved outcomes in conditions by incorporating controlled randomness. Understanding patterns has significant diagnosis, treatment monitoring, development medical conditions.

Language: Английский

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Improved prediction and risk stratification of major adverse cardiovascular events using an explainable machine learning approach combining plasma biomarkers and traditional risk factors

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 2, 2025

Language: Английский

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Association of Klotho and FGF23 with cardiovascular outcomes in diabetic older adults with chronic limb-threatening ischemia: a prospective study

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

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Higher intraindividual variability of body mass index is associated with elevated risk of COVID-19 related hospitalization and post-COVID conditions

International Journal of Obesity, Journal Year: 2024, Volume and Issue: 48(12), P. 1711 - 1719

Published: Aug. 12, 2024

Language: Английский

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Exposure to air pollution, genetic susceptibility, and prevalence of sarcopenia in the UK

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117143 - 117143

Published: Oct. 1, 2024

The role of environmental factors, particularly air pollutants, in the prevalence sarcopenia remains unclear.

Language: Английский

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Epidemiology of Cardiovascular Risk Trajectories Following a Diagnosis of Anorexia Nervosa

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(12), P. e2451047 - e2451047

Published: Dec. 19, 2024

Language: Английский

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