How do we increase deceased donor kidney utilization and reduce discard?

Current Opinion in Organ Transplantation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Purpose of review This aims to address the critical issue expanding deceased donor kidney pool and reducing discard rates viable kidneys in United States. It highlights advances organ preservation techniques explores strategies for by leveraging suboptimal high-risk nonuse kidneys, including those affected acute injury (AKI), hepatitis C virus (HCV), B (HBV). Recent findings Innovations preservation, hypothermic normothermic machine perfusion, have demonstrated efficacy improving outcomes marginal extended-criteria kidneys. The integration regional perfusion (NRP) donation after cardiac death (DCD) donors has enhanced utilization graft viability. Additionally, research confirms that from AKI HCV-positive donors, when managed with appropriate protocols, yield comparable long-term standard transplants. Emerging data on HBV-positive further underscore their potential safely expand transplant access targeted antiviral prophylaxis. Summary Optimizing requires a multi-faceted approach, advancements technologies, evidence-based decision-making organs, policy innovations. Leveraging these can help growing shortage, enhance outcomes, ensure broader life-saving

Language: Английский

---

Ethical and legal considerations in normothermic regional perfusion for donation after circulatory death

Current Opinion in Critical Care, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Purpose of review This study aims to examine the ethical and legal discourse surrounding normothermic regional perfusion (NRP) for donation after circulatory death (DCD). Recent findings NRP is well established within Europe but faces challenges in US not utilized a variety other countries. compliance with dead donor rule (DDR) Uniform Declaration Death Act (UDDA) most significant recently addressed issue. Additionally, procedures raise concerns regarding public education, informed consent, engagement, trust. Inconsistent regulation – such as US– cause concern anticipated increase frequency support organ recovery transplantation. There no single repository technical outcome data practice refinement key aspect given variation between centers Summary NRP-based presents be by transplantation clinicians organizations conjunction representatives. Additional inquiry into determination death, family information needs authorization, coordinated needed ensure that are appropriately addressed. Public engagement essential bolster preserve

Language: Английский

---

Organ Procurement Organization-Based Normothermic Regional Perfusion in the US: Current State and Future Direction

Current Transplantation Reports, Journal Year: 2025, Volume and Issue: 12(1)

Published: May 2, 2025

Language: Английский

---

Normothermic Regional Perfusion for Organ Donation in the US—The Dangers of Unregulated Adoption

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(10), P. e2440017 - e2440017

Published: Oct. 24, 2024

Marty T. Sellers, MD, MPH; Jennifer L. Philip, MD; Aleah Brubaker, PhD; Roxane Cauwels, MBA; Kristopher P. Croome, MS; Jordan R. Hoffman, Nikole A. Neidlinger, Andrea M. Reynolds, BFA; Anji E. Wall, John Edwards, RN

Language: Английский

---