Clinical state and future directions of stem cell therapy in stroke rehabilitation DOI
Pardes Habib, Gary K. Steinberg

Experimental Neurology, Journal Year: 2024, Volume and Issue: 385, P. 115132 - 115132

Published: Dec. 30, 2024

Language: Английский

Human iPSC-derived cell grafts promote functional recovery by molecular interaction with stroke-injured brain DOI Creative Commons
R. Weber, Beatriz Achón Buil, Nora H. Rentsch

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 5, 2024

Abstract Stroke is a leading cause of disability and death due to the brain’s limited ability regenerate damaged neural circuits. To date, stroke patients have only few therapeutic options are often left with considerable disabilities. Induced pluripotent stem cell (iPSC)-based therapies emerging as promising approach for recovery. In this study, we demonstrate that local transplantation good manufacturing practice (GMP)-compatible iPSC-derived progenitor cells (NPCs) improve long-term recovery-associated brain tissue responses reduce neurological deficits after cerebral ischemia in mice. Using vivo bioluminescence imaging post-mortem histology, showed graft survival over course five weeks preferential differentiation into mature neurons without signs residuals. Transplantation NPCs led set including increased vascular sprouting repair, improved blood-brain barrier integrity, reduced microglial activation, neurogenesis compared littermate control animals receiving sham transplantation. Employing deep learning-assisted behavior analysis, found NPC-treated mice displayed gait performance complete fine-motor recovery horizontal ladder rung walk, post-injury. dissect molecular composition identify graft-host interactions, single nucleus profiling transplants host was performed. We identified preferentially towards GABAergic remaining acquiring glutamatergic neuron, astrocyte, NPC-like phenotypes. Interaction between transcriptome indicated grafts were primarily involved communication through regeneration-associated NRXN, NRG, NCAM SLIT signalling pathways. conclusion, our study reveals transplanted differentiate contributing recovery, further delineates regenerative interactions stroke-injured tissue.

Language: Английский

Citations

8
Revolutionizing Stroke Recovery: Unveiling the Promise of Stem Cell Therapy DOI Creative Commons
Leonidas D Panos, Panagiotis Bargiotas, Marcel Arnold

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 991 - 1006

Published: March 1, 2024

Stem cells, renowned for their unique regenerative capabilities, present significant hope in treating stroke, a major cause of disability globally.This review offers detailed analysis stem cell applications stroke (ischemic and hemorrhagic) recovery.It examines therapies based on autologous (patient-derived), allogeneic (donor-derived), Granulocyte-Colony Stimulating Factor (G-CSF) focusing types such as Mesenchymal Stem/Stromal Cells (MSCs), Bone Marrow Mononuclear (BMMSCs), Neural Stem/Progenitor (NSCs).The paper compiles clinical trial data to evaluate effectiveness safety addresses the ethical concerns these innovative treatments.By explaining mechanisms cell-induced neurological repair, this underscores cells' potential revolutionizing rehabilitation suggests avenues future research.

Language: Английский

Citations

7
Brain repair mechanisms after cell therapy for stroke DOI Creative Commons
Ruslan Rust, Lina R. Nih, Luca Liberale

et al.

Brain, Journal Year: 2024, Volume and Issue: 147(10), P. 3286 - 3305

Published: June 25, 2024

Cell-based therapies hold great promise for brain repair after stroke. While accumulating evidence confirms the preclinical and clinical benefits of cell therapies, underlying mechanisms by which they promote remain unclear. Here, we briefly review endogenous ischaemic stroke then focus on how different stem progenitor sources can repair. Specifically, examine transplanted grafts contribute to improved functional recovery either through direct replacement or stimulating pathways. Additionally, discuss recently implemented refinement methods, such as preconditioning, microcarriers, genetic safety switches universal (immune evasive) transplants, well therapeutic potential these pharmacologic manipulations further enhance efficacy therapies. By gaining a deeper understanding post-ischaemic mechanisms, prospective trials may be refined advance post-stroke therapy clinic.

Language: Английский

Citations

7
Breaking through barrier: The emerging role of nucleic acids-based drug delivery in stroke DOI

Guo Yin,

Yufeng Zheng,

Ming Li

et al.

Progress in Materials Science, Journal Year: 2025, Volume and Issue: 151, P. 101436 - 101436

Published: Jan. 23, 2025

Language: Английский

Citations

0
Interleukin-27 deletion has neuroprotective effects in the acute ischemic stage of cerebral infarction DOI
Takashi Furukawa, Yasunobu Miyake,

Hiroshi Ito

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151581 - 151581

Published: March 1, 2025

Language: Английский

Citations

0
Safety and Efficacy of Stem Cell Therapy in Ischemic Stroke: A Comprehensive Systematic Review and Meta-Analysis DOI Open Access
Abdulrahim Saleh Alrasheed,

Tala Abdullah Aljahdali,

Israa Aqeel Alghafli

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 2118 - 2118

Published: March 20, 2025

Background: Although recent advancements in ischemic stroke management have reduced associated mortality rates, there remains a pressing need for more reliable, efficacious, and well-tolerated therapeutic approaches due to the narrow window of current treatment approaches. The meta-analysis sought evaluate safety efficacy stem cell-based options patients with stroke. Methods: PubMed, Web Science, Cochrane library databases were searched retrieve randomized controlled trials (RCTs) evaluating cell therapy (SCT) patients. Key outcomes included National Institutes Health Stroke Scale (NIHSS), modified Rankin (mRS), Barthel Index (BI), Fugl–Meyer Assessment (FMA), infarct size, profile. random effects model continuous method was used calculate pooled effect size Review Manager 5.4.1, subgroup analyses performed based on demographics, duration, SCT delivery protocols. Results: A total 18 RCTs involving 1026 analyzed, 538 group 488 control group. mean change NIHSS score comparable between groups [MD = −0.80; 95% CI: −2.25, 0.65, p < 0.0001]. However, showed better mRS −0.56; −0.76, −0.35, 0.30] BI scores 12.00; 4.00, 20.00, 0.007]. Additionally, FMA significantly greater 18.16; 6.58, 29.75, 0.03]. volume also favored 8.89; −5.34, 23.12, 0.08]. profile favorable, adverse event rates or lower than controls. Conclusions: offers safe effective approach improving functional patients, particularly early intervention. These findings highlight potential rehabilitation while underscoring standardized protocols long-term evaluation.

Language: Английский

Citations

0
Multipotent Adult Progenitor Cells DOI
Pooja Swami, Henintsoa Fanjaniaina Andriamifidy,

Apratim Maity

et al.

Published: Jan. 1, 2025

Citations

0
Imaging technology in tracking the intravital fate of transplanted stem cells DOI Creative Commons

Liming Shen,

Chengze Li, Yulian Li

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107752 - 107752

Published: April 1, 2025

Language: Английский

Citations

0
Targeting mitochondrial transfer as a promising therapeutic strategy DOI
Bo Li, Bingzhi Li, Xianghe Qiao

et al.

Trends in Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
SIRT-1/RHOT-1/PGC-1α loop modulates mitochondrial biogenesis and transfer to offer resilience following endovascular stem cell therapy in ischemic stroke DOI
Deepaneeta Sarmah, Aishika Datta,

Nikita Rana

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 225, P. 255 - 274

Published: Sept. 19, 2024

Language: Английский

Citations

3