Structural compromise in spiking cortex and connected networks DOI Creative Commons
Ella Sahlas, Tamir Avigdor, Alexander Ngo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

ABSTRACT INTRODUCTION Epilepsy is increasingly conceptualized as a network disorder, and advancing methods for its diagnosis treatment requires characterizing both the epileptic generator related networks. We combined multimodal magnetic resonance imaging (MRI) high-density electroencephalography (HD-EEG) to interrogate alterations in cortical microstructure, morphology, intrinsic local function within beyond spiking tissue focal epilepsy. METHODS studied 25 patients with epilepsy (12F, mean ± SD age = 31.28 9.30 years) 55 age- sex-matched healthy controls, subdivided into group of 30 feature normalization (15F, 31.40 8.74 replication 31.04 5.65 years). The 3T MRI acquisition included T1-weighted, diffusion, quantitative T1 relaxometry, resting-state functional imaging. Open-access processing tools derived cortex-wide maps morphology microstructure (cortical thickness, diffusivity, relaxometry) connectivity (timescales, distance, node strength) all participants. Multivariate approaches generated structural alteration scores each location. Using HD-EEG electrical source imaging, most prominent spike type was localized we quantified sources, well proximal connected RESULTS Regions harboring sources showed increased compared rest brain patients. Structural compromise extended regions close coupling but not anatomical neighbors sources. This finding replicated using average control matrices instead patient-specific matrices. CONCLUSION Spiking contain more marked than remaining cortex, combining neurophysiology techniques may ultimately help identify epileptogenic zone non-invasively. There are nevertheless broader networks effects, which relate cascading changes functionally cortices. These results underscore utility high-definition EEG assessing distributed effects.

Language: Английский

Connectome architecture for gray matter atrophy and surgical outcomes in temporal lobe epilepsy DOI Open Access
Qiuxing Lin,

Danyang Cao,

Wei Li

et al.

Epilepsia, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Temporal lobe epilepsy (TLE) has been recognized as a network disorder with widespread gray matter atrophy. However, the role of connectome architecture in shaping morphological alterations and identifying atrophy epicenters remains unclear. Furthermore, individualized modeling their potential clinical applications have not well established. This study aims to explore how correlates normal architecture, identify epicenters, employ approach evaluate impact different epicenter patterns on surgical outcomes patients TLE. utilized anatomic MRI data from 126 refractory TLE who underwent anterior temporal lobectomy 60 healthy controls (HCs), along normative functional structural data, investigate relationship between volume (GMV) changes or connectivity. Two models were employed epicenters: data-driven evaluating nodal neighbor rankings, diffusion model (NDM) simulating spread pathology seed regions. K-means clustering was applied patient-tailored uncover distinct subtypes. Our findings indicate that pattern is constrained primarily by connectivity rather than Using connectome, we pinpointed hippocampus adjacent temporo-limbic regions key epicenters. The revealed significant variability distribution, allowing us categorize them into two Notably, subtype 2, localized ipsilateral pole medial lobe, exhibited significantly higher seizure-free rates compared 1, whose situated frontocentral These highlight central TLE-related changes. Individualized may enhance decisions improve prognostic stratification management.

Language: Английский

Citations

0
A generalized epilepsy network derived from brain abnormalities and deep brain stimulation DOI Creative Commons
Gong‐Jun Ji, Michael Fox,

Mae Morton-Dutton

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 24, 2025

Abstract Idiopathic generalized epilepsy (IGE) is a brain network disease, but the location of this and its relevance for treatment remain unclear. We combine locations abnormalities in IGE (131 coordinates from 21 studies) with human connectome to identify an network. validate by showing alignment structural previously identified areas activated epileptiform discharges simultaneous electroencephalogram-functional magnetic resonance imaging. The topography aligns networks involved motor control loss consciousness consistent seizure semiology. To investigate therapeutic relevance, we analyze data patients treated deep stimulation (DBS) seizures. Seizure frequency reduced median 90% after DBS sites intersect peak centromedian nucleus thalamus. Together, study helps unify prior findings target that can be tested clinical trials

Language: Английский

Citations

0
The safety and effectiveness of tDCS for epileptic patients： A systematic review and meta-analysis DOI Creative Commons
Xiaofeng Ding, Mingyu Hu, Chi Wang

et al.

Complementary Therapies in Medicine, Journal Year: 2025, Volume and Issue: 89, P. 103142 - 103142

Published: Feb. 3, 2025

Although transcranial direct current stimulation (tDCS) has been used in the treatment of epilepsy for many years, further research is needed on efficacy and safety tDCS treatment. This systematic review meta-analysis aimed to explore effectiveness seizure frequency(SF), epileptiform discharges, depression, anxiety, cognitive function epilepsy. We searched Cochrane Library, PubMed, Embase, Scopus, Web Science databases from inception 9 September 2024. The primary outcomes included SF. secondary EDs, function, adverse events. was conducted using Review Manager 5.4 software. 12 trials were included, 356 participants (219 group 137 sham group). Among studies, three high risk, two some concern, seven low risk. For outcome metrics, can reduce frequency epileptic seizures (SMD = -0.63, 95% CI [-0.90, -0.36], P< 0.00001). measures, there are no statistical differences between discharges -0.27, [-0.71, 0.16], P 0.22) events (MD 1.30, [0.49, 3.45], =0.60). depression anxiety inconsistent. did not enhance or impair function. SF but effect patients with evidence limited support patients. Future studies should be standardized personalized, ensure higher methodological rigor, probe long-term effects prove findings further.

Language: Английский

Citations

0
Brain Volume Loss After Stereotactic Laser Interstitial Thermal Therapy in Patients With Temporal Lobe Epilepsy DOI Creative Commons
Sebastian Johannes Müller, Eya Khadhraoui,

O. Kukhlenko

et al.

Journal of Neuroimaging, Journal Year: 2025, Volume and Issue: 35(2)

Published: March 1, 2025

ABSTRACT Background and Purpose Temporal lobe epilepsy is the most common form of focal epilepsy. MR‐guided laser interstitial thermal therapy (LITT) amygdalohippocampal complex has become an established option in case drug resistance. Long‐term anatomic network effects on brain due to deafferentiation have not yet been evaluated. Methods We analyzed volumes 11 patients with temporal before 1‐year after hippocampal LITT FastSurfer segmenting T1‐weighted data. Additionally, we performed visual ratings measurements. Results A total (7 left‐sided, 4 right‐sided) were included (5 females); mean age years (±standard deviation) at surgery was 41.5 (±18.4) years. The postoperative defect size 1427 (±517) mm 3 . Volumetry as well found a progressive volume loss left‐sided ipsilateral lobe, contralateral (right) part thalamus, especially fusiform cortex. These changes could be detected for right‐sided surgery. Conclusion (partial) ablation left (dominant) hippocampus appears exert long‐term right thalamus cortices. However, observe this effect reverse direction. Volumetric studies larger cohorts should conducted investigate these findings.

Language: Английский

Citations

0
Structural compromise in spiking cortex and connected networks DOI Creative Commons
Ella Sahlas, Tamir Avigdor, Alexander Ngo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

ABSTRACT INTRODUCTION Epilepsy is increasingly conceptualized as a network disorder, and advancing methods for its diagnosis treatment requires characterizing both the epileptic generator related networks. We combined multimodal magnetic resonance imaging (MRI) high-density electroencephalography (HD-EEG) to interrogate alterations in cortical microstructure, morphology, intrinsic local function within beyond spiking tissue focal epilepsy. METHODS studied 25 patients with epilepsy (12F, mean ± SD age = 31.28 9.30 years) 55 age- sex-matched healthy controls, subdivided into group of 30 feature normalization (15F, 31.40 8.74 replication 31.04 5.65 years). The 3T MRI acquisition included T1-weighted, diffusion, quantitative T1 relaxometry, resting-state functional imaging. Open-access processing tools derived cortex-wide maps morphology microstructure (cortical thickness, diffusivity, relaxometry) connectivity (timescales, distance, node strength) all participants. Multivariate approaches generated structural alteration scores each location. Using HD-EEG electrical source imaging, most prominent spike type was localized we quantified sources, well proximal connected RESULTS Regions harboring sources showed increased compared rest brain patients. Structural compromise extended regions close coupling but not anatomical neighbors sources. This finding replicated using average control matrices instead patient-specific matrices. CONCLUSION Spiking contain more marked than remaining cortex, combining neurophysiology techniques may ultimately help identify epileptogenic zone non-invasively. There are nevertheless broader networks effects, which relate cascading changes functionally cortices. These results underscore utility high-definition EEG assessing distributed effects.

Language: Английский

Citations

0