Cancer Biomarkers,
Journal Year:
2025,
Volume and Issue:
42(1)
Published: Jan. 1, 2025
Background
Oropharyngeal
cancer
rates
continue
to
rise
with
no
effective
screening
method.
Persistent
oral
oncogenic
human
papillomavirus
(HPV),
antibodies
HPV16
early
(E)
oncoproteins,
and
circulating
tumor
HPV
DNA
(ctHPVDNA)
are
biomarkers
that
show
promise
for
use
in
HPV-related
screening.
Objective
To
assess
the
prevalence
of
their
agreement
middle-aged
men.
Methods
Men
aged
50–64
years
from
general
population
provided
rinse
blood
samples
as
well
information
about
demographics,
tobacco/alcohol
exposure,
sexual
behavior,
disease
history.
Oral
was
tested
plasma
E
ctHPVDNA
using
a
droplet
digital
PCR
(ddPCR)-based
assay
measures
tissue
modified
viral
(TTMV)-HPV
(NavDx,
Naveris,
Inc.).
We
calculated
frequency
distributions
variables
interest
between
biomarkers.
Results
enrolled
1045
subjects
April
2017
2024.
The
954
results
all
three
were
included
analysis.
4.9%
DNA,
0.7%
antibodies,
0.5%
TTMV-HPV
DNA.
Conclusions
low
shows
potential
identify
high-risk
individuals
eligible
further
clinical
Current Opinion in Oncology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 6, 2025
Purpose
of
review
Patients
with
HPV-related
oropharyngeal
cancer
have
very
good
survival
outcomes
but
a
high
burden
toxicity.
This
has
led
to
significant
efforts
attempt
use
variety
biomarkers
select
patients
who
are
candidates
for
de-escalated
treatment.
Recent
findings
Initially,
the
field
used
HPV
status
alone
as
biomarker
de-escalation,
however,
recently
presented
results
NRG
Oncology
HN005
showed
that
this
is
an
insufficient
strategy
potential
de-escalation
in
study
received
60
Gy
rather
than
standard
70
radiation
had
diminished
progression-free
survival.
myriad
other
strategies
potentially
identify
may
be
able
receive
less
intense
treatment
maintain
rate
cure.
Summary
Many
options
exist
try
and
de-escalation.
We
anxiously
await
multiple
ongoing
phase
II
studies
regarding
many
these
believe
future
will
significantly
more
personalized.
Archives of Microbiology,
Journal Year:
2025,
Volume and Issue:
207(4)
Published: Feb. 28, 2025
Abstract
The
oral
viral
microbiome
(or
virome),
encompassing
a
diverse
community
of
viruses
within
the
cavity,
has
emerged
as
significant
yet
underexplored
factor
in
head
and
neck
cancers
(HNCs).
This
review
synthesizes
recent
evidence
linking
virome
to
carcinogenesis,
particularly
oropharyngeal
nasopharyngeal
carcinomas—the
most
common
virus-associated
subtypes
HNCs.
Beyond
pathogenesis,
diagnostic
therapeutic
implications
are
explored,
including
non-invasive
salivary
detection
biomarkers
for
early
cancer
diagnosis,
development
targeted
antiviral
therapies,
preventive
vaccination
strategies—exemplified
by
success
HPV
vaccines
reducing
incidence
cancers.
Despite
these
advancements,
challenges
persist,
technical
limitations,
need
longitudinal
studies,
integration
multi-omics
approaches.
A
comprehensive
understanding
could
revolutionize
diagnostics,
therapeutics,
prevention.
Moving
forward,
collaborative
interdisciplinary
efforts
will
be
essential
fully
leverage
research
improving
HNC
outcomes.
International Journal of Environmental Research and Public Health,
Journal Year:
2025,
Volume and Issue:
22(3), P. 439 - 439
Published: March 17, 2025
(1)
Introduction:
Human
papillomavirus
(HPV)
is
a
significant
public
health
concern
associated
with
various
cancers,
including
rising
incidence
of
oropharyngeal
cancer
(OPC).
Despite
the
availability
effective
vaccines
targeting
high-risk
HPV
types,
vaccination
rates
remain
suboptimal.
Dental
professionals
are
uniquely
positioned
to
contribute
prevention
through
education,
advocacy,
and
early
detection.
(2)
Methods:
This
narrative
review
synthesized
literature
from
2006
2024
on
epidemiology,
pathophysiology,
vaccine
efficacy,
role
dental
providers
in
prevention.
Sources
included
peer-reviewed
articles
listed
Pubmed
Google
Scholar,
observational
studies
articles,
guidelines,
clinical
trials,
governmental
data.
Key
barriers
HPV-related
care
practice
strategies
for
overcoming
them
were
analyzed.
(3)
Results:
The
underscores
critical
dentists
disease
prevention,
highlighting
their
ability
detect
lesions,
promote
uptake,
address
patient
concerns.
Barriers
such
as
limited
knowledge,
discomfort
discussing
HPV,
misinformation
identified.
Strategies
like
incorporating
education
into
training,
utilizing
emerging
diagnostic
tools,
adopting
communication
approaches
can
enhance
reducing
HPV-associated
risks.
(4)
Conclusion:
By
integrating
detection
routine
care,
play
transformative
health.
A
provider's
endorsement
increase
uptake
help
prevent
oral
cancer.
These
efforts
align
broader
promotion
goals,
offering
opportunity
reduce
burden
cancers
improve
long-term
outcomes.
Otolaryngology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
Abstract
Objective
In
2020,
the
Food
and
Drug
Administration
(FDA)
approved
Merck's
GARDASIL
9
for
prevention
of
certain
human
papillomavirus
(HPV)‐related
head
neck
cancer.
This
study
characterizes
sentiment
themes
HPV
vaccination
online
discourse
surrounding
2020
FDA
recommendation.
Study
Design
Retrospective
cohort.
Setting
Data
from
2018
to
2022:
Reddit,
Teen
VaxView
(Centers
Disease
Control
Prevention),
Google
Trends.
Methods
Online
public
was
assessed
by
searching
Reddit
user
submitted
posts
using
relevant
keywords.
were
categorized
a
trained
machine
learning
classifier.
Natural
language
processing
calculated
positive/negative
sentiment,
polarity,
frequent
nonstop
words.
Trends
relative
search
popularity,
TeenVaxView
vaccinations
among
adolescents.
Statistical
relationships
linear
logarithmic
regression
models.
Results
Analysis
2751
demonstrated
balanced
overall
with
substantial
positive
trend
over
period
(
P
=
.05).
Most
personal
stories/questions
(n
1997,
72.6%)
conspiracy
made
up
just
small
minority
186,
6.8%).
Discussion
including
anatomical
cancer
terms
significantly
increased
.01).
Vaccination
coverage
trended
upward
males
females
<
A
significant
relationship
found
between
.02).
Conclusion
Discourse
vaccine
has
been
increasingly
in
changes
guidelines
correlated
discussion
HPV‐related
There
concurrent
adolescent
rate.
Cancer Biomarkers,
Journal Year:
2025,
Volume and Issue:
42(1)
Published: Jan. 1, 2025
Background
Oropharyngeal
cancer
rates
continue
to
rise
with
no
effective
screening
method.
Persistent
oral
oncogenic
human
papillomavirus
(HPV),
antibodies
HPV16
early
(E)
oncoproteins,
and
circulating
tumor
HPV
DNA
(ctHPVDNA)
are
biomarkers
that
show
promise
for
use
in
HPV-related
screening.
Objective
To
assess
the
prevalence
of
their
agreement
middle-aged
men.
Methods
Men
aged
50–64
years
from
general
population
provided
rinse
blood
samples
as
well
information
about
demographics,
tobacco/alcohol
exposure,
sexual
behavior,
disease
history.
Oral
was
tested
plasma
E
ctHPVDNA
using
a
droplet
digital
PCR
(ddPCR)-based
assay
measures
tissue
modified
viral
(TTMV)-HPV
(NavDx,
Naveris,
Inc.).
We
calculated
frequency
distributions
variables
interest
between
biomarkers.
Results
enrolled
1045
subjects
April
2017
2024.
The
954
results
all
three
were
included
analysis.
4.9%
DNA,
0.7%
antibodies,
0.5%
TTMV-HPV
DNA.
Conclusions
low
shows
potential
identify
high-risk
individuals
eligible
further
clinical
