Diagnostic Accuracy of Circulating Tumor HPV DNA Testing in Patients With a Lateral Neck Mass DOI
Rocco Ferrandino, Joshua Barlow, Brandon Gold

et al.

JAMA Otolaryngology–Head & Neck Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

The most frequent presenting symptom for patients with human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a lateral neck mass. Circulating tumor tissue-modified viral (TTMV)-HPV DNA unique biomarker produced by the fragmentation of HPV during degradation HPV-associated tumors, and its detection quantitation are currently being used as an adjunct to imaging in monitoring disease recurrence may have utility diagnosis.

Language: Английский

Evaluating human papillomavirus testing, prevalence, and association with prognosis in head and neck squamous cell carcinoma by subsite: A national cancer database study DOI
Joshua Barlow, Shivee Gilja, Rocco Ferrandino

et al.

American Journal of Otolaryngology, Journal Year: 2024, Volume and Issue: 45(3), P. 104243 - 104243

Published: Feb. 28, 2024

Language: Английский

Citations

3
Reappraisal of p16 for Determining HPV Status of Head and Neck Carcinomas Arising in HPV Hotspots DOI
Swati Bhardwaj, Melissa Gitman, Juan David Ramírez

et al.

The American Journal of Surgical Pathology, Journal Year: 2024, Volume and Issue: 48(5), P. 581 - 587

Published: March 14, 2024

In an era of head and neck oncology where HPV status will soon dictate patient management, reliable detection is critical. P16 immunohistochemistry (IHC) currently recommended as the test choice for oropharyngeal squamous cell carcinomas (OPSCCs). The purpose this study was to determine performance characteristics p16 IHC based on a large clinical experience (SCC) arising from hot-spot regions neck. Consecutive OPSCCs, sinonasal SCCs, metastatic SCCs unknown primary sites were evaluated presence by PCR-based DNA testing part care. For discrepant cases, high-risk E6/E7 mRNA in situ hybridization (ISH) and, when possible, matrix-assisted laser desorption/ionization—time flight (MALDI-TOF) mass spectrometry (MassArray) genotyping performed. 746 cancers underwent PCR genotyping. There 95.6% concordance between 2 assays. Of 33 32 cases (4.3%) positive but negative. these 68% ISH, invariably related non-16 genotype. had overall accuracy 98.8%, sensitivity 99.8%, specificity 92.1%. sensitive specific assay determining status. appears vulnerable genotype diversity prone missing rare genotypes. ISH practical direct measure that may help eliminate small number false-positive avoid potential harm erroneous classification.

Language: Английский

Citations

3
Assessing the Evidence for Circulating Tumor HPV DNA in Patients With Oropharyngeal Cancer DOI
Nancy Y. Lee, Luc G.T. Morris, Maximilian Diehn

et al.

JAMA Oncology, Journal Year: 2024, Volume and Issue: 10(8), P. 1021 - 1021

Published: June 27, 2024

This Viewpoint evaluates the use of tumor tissue–modified human papillomavirus (HPV) DNA in identifying minimal residual disease.

Language: Английский

Citations

3
Clinical validation of a tissue-agnostic genome-wide methylome enrichment MRD assay for head and neck malignancies DOI Creative Commons
Geoffrey Liu,

Shao Hui Huang,

Laurie Ailles

et al.

Annals of Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

2
Diagnostic Accuracy of Circulating Tumor HPV DNA Testing in Patients With a Lateral Neck Mass DOI
Rocco Ferrandino, Joshua Barlow, Brandon Gold

et al.

JAMA Otolaryngology–Head & Neck Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

The most frequent presenting symptom for patients with human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a lateral neck mass. Circulating tumor tissue-modified viral (TTMV)-HPV DNA unique biomarker produced by the fragmentation of HPV during degradation HPV-associated tumors, and its detection quantitation are currently being used as an adjunct to imaging in monitoring disease recurrence may have utility diagnosis.

Language: Английский

Citations

2