The soluble receptor for advanced glycation end products is independently associated with systolic blood pressure values and hypertension in children

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 103862 - 103862

Published: Jan. 1, 2025

Language: Английский

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Multiple office blood pressure monitoring for the diagnosis of hypertension in children

European Journal of Pediatrics, Journal Year: 2025, Volume and Issue: 184(3)

Published: Feb. 27, 2025

The measurement (M) of blood pressure (BP) in children may be challenging, and the ideal approach, free critical issues (such as interference due to white coat effect or high variability), has yet identified. Herein, we compare BP measured with multiple office monitoring (mOBPM) standard approach suggested by guidelines. A cohort healthy underwent two mOBPMs 1 year apart. Mean systolic diastolic values obtained mOBPM were compared 1st, 2nd, 3rd, 4th measurements (repeated measures ANOVA). a coefficient variation (CV) > 15% excluded. number 90th centile was determined based on (a) each initial three readings, (b) mean 2nd 3rd Ms, (c) M, (d) at baseline, (e) Out 164 enrolled children, 13 (7.9%) excluded because CV 15%. analysis remaining 151 showed that first Ms provided significantly higher than mOBPM. M one aligned results Based observed 29, 20, 21, 16 respectively. identified 12 BP, while revealed elevated only 6 this finding confirmed 3 them later. readings systematically overestimate better aligns If reading is abnormal, complete will likely offer more reliable assessment. • Blood challanging real values. 10 measurements. In daily clinical practice, if (www.mobpm.com)

Language: Английский

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Maternal Cardiometabolic Risk Factors in Pregnancy and Offspring Blood Pressure at Age 2 to 18 Years

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(5), P. e259205 - e259205

Published: May 8, 2025

Importance Higher blood pressure in early life may signal cardiovascular disease over the course, but determinants of are poorly understood. Objective To examine association maternal cardiometabolic risk factors during pregnancy with offspring from age 2 to 18 years and explore whether is modified by sex race ethnicity. Design, Setting, Participants This cohort study analyzed data Environmental Influences on Child Health Outcomes program between January 1, 1994, March 31, 2023. Three common were examined: prepregnancy obesity, gestational diabetes, hypertensive disorders (HDP). Exposure Maternal retrieved harmonized medical records questionnaires. Main Measures Offspring systolic (SBP) diastolic (DBP) percentiles adjusted for age, sex, height calculated. Results Among 12 480 mother-offspring pairs (mean [SD] pregnancy, 29.9 [6.4] years; 856 303 identifying as Asian [7.0%]; 1908 Black [15.5%]; 2305 Hispanic [18.7%]; 6522 White [52.3%], 712 other [5.8%] ethnicity), at least 1 factor was present 5537 (44.4%), obesity being most prevalent (3072 [24.6%]), followed HDP (1693 [13.6%]) diabetes (805 [6.5%]). born mothers any had higher SBP (4.88 percentile points; 95% CI, 3.97-5.82 points) DBP (1.90 1.15-2.64 their first measurement, after adjusting potential confounders, compared counterparts without factors. Hypertensive alone or either significantly associated pressure. These associations generally more significant among female male racial ethnic groups. 6015 who measures, an increased rate change (SBP percentile, 0.5 [95% 0.2-0.8] per year; 0.7 CI 0.5-1.0] year). Conclusions Relevance findings suggest that protecting pregnant individuals promote healthier next generation.

Language: Английский

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Pediatric Blood Pressure and Cardiovascular Health in Adulthood

Current Hypertension Reports, Journal Year: 2024, Volume and Issue: unknown

Published: June 15, 2024

Abstract Purpose of Review This review summarizes current knowledge on blood pressure in children and adolescents (youth), with a focus primary hypertension—the most common form elevated this demographic. We examine its etiology, progression, long-term cardiovascular implications. The covers definitions recommendations classifications, recent developments measurement, epidemiological trends, findings from observational clinical studies, prevention treatment, while identifying gaps understanding suggesting future research directions. Recent Findings Youth hypertension is an escalating global issue, regional national variations prevalence. While the principles measurement have remained largely consistent, challenges age group include scarcity automated devices that passed independent validation for accuracy generally limited tolerance ambulatory monitoring. A multifaceted interplay factors contributes to youth hypertension, impacting health. including meta-analysis sophisticated life-course modelling, reveal adverse link between subclinical outcomes later life. New evidence now provides strongest yet linking events adulthood. Some trials expanded our safety efficacy antihypertensive medications youth, but remains area requires additional attention, particularly regarding varied screening approaches. Summary outlines potential role preventing managing reduce risk. perspective necessary formulating strategies, considering specific needs circumstances low- middle-income countries compared high-income countries.

Language: Английский

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Is there an association between eye-level greenness and childhood hypertension using street view? Findings from the Seven Northeastern Cities study in China

Environmental Research, Journal Year: 2025, Volume and Issue: 268, P. 120768 - 120768

Published: Jan. 4, 2025

Language: Английский

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Cardio-Kidney Metabolic Health in Pediatrics and Primordial Prevention

Cardiology Clinics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Clinical and epidemiological significance of stress-induced impact of psychotraumatic factors of the war in Ukraine and the COVID-19 pandemic on the development of pathological changes in the cardiovascular system in children

CHILD`S HEALTH, Journal Year: 2025, Volume and Issue: 20(2), P. 154 - 162

Published: April 22, 2025

Cardiovascular diseases (CVD) remain one of the leading causes morbidity and mortality worldwide. At same time, they are increasingly emerging as a consequence adverse factors inherent in childhood. Epidemiological research data confirm that critical periods early development, particular influence socio-economic disadvantage psychological stress, decisive importance for formation CVD risk adulthood. In recent years, Ukraine has been experiencing prolonged crisis, military conflicts COVID-19 pandemic. These circumstances significantly affect status families health children. According to Bürgin et al. (2023), living conflict zone forced migration have far-reaching consequences psychosocial physical children, creating additional risks developing chronic pathologies, CVD. Despite significant body evidence linking childhood trauma adult disease, role remains poorly understood terms their contribution cardiovascular particularly pathophysiological mechanisms such neuroendocrine activation, epigenetic programming, metabolic abnormalities, vascular dysfunction.

Language: Английский

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Chronic Kidney Disease or Hypertension After Childhood Cancer

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(5), P. e258199 - e258199

Published: May 19, 2025

Importance Post–cancer therapy kidney outcomes, including chronic disease (CKD) and hypertension, are common in childhood cancer survivors (CCS). The incidence timing of CKD hypertension CCS compared with other at-risk or general populations unclear. Objective To determine the association treatment post–cancer hypertension. Design, Setting, Participants Population-based matched cohort study children treated for between April 1993 March 2020 Ontario, Canada, follow-up until 2021. (exposed) included (≤18 years) surviving cancer. Comparator cohorts were a hospitalization (children who hospitalized) pediatric population (GP) (all Ontario children). Exclusion criteria history previous cancer, organ transplant, CKD, dialysis, Matching each 2 comparator was performed separately 1:4 ratio by age, sex, rural vs urban status, income quintile, index year, presence hospitalization. Data analyzed from 2021 to August 2024. Exposure Treatment Main Outcomes Measures primary outcome composite defined administrative health care diagnosis procedure codes. Fine Gray subdistribution hazard modeling, accounting competing risks (death new relapse) adjusting cardiac disease, liver diabetes, used outcomes. Results There 10 182 (median [IQR] age at diagnosis, 7 [3-13] years; 5529 male [54.3%]; median time, 8 [2-15] 40 728 patients [2-12] [weighted percentage, 54.3%]; 11 [6-18] 8849 5 [2-11] 4825 [54.5%]; [2-14] 35 307 GP individuals 6 54.5%]; [5-16] years). Most frequent types leukemia (2948 [29.0%]), central nervous system neoplasms (2123 [20.9%]), lymphoma (1583 [15.5%]). During observation, cumulative 20.85% (95% CI, 18.75%-23.02%) 16.47% 15.21%-17.77%) 19.24% 15.99%-22.73%) 8.05% 6.76%-9.49%) cohort. increased risk (adjusted ratio, 2.00; 95% 1.86-2.14; P < .001) 4.71; 4.27-5.19; .001). Conclusions Relevance In this population-based study, which associated mortality, suggesting that early detection these conditions may decrease late complications mortality.

Language: Английский

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Approach to Diagnosis and Management of Pediatric Hypertension in an Outpatient Setting

Indian Journal of Nephrology, Journal Year: 2025, Volume and Issue: 0, P. 1 - 10

Published: May 21, 2025

Pediatric hypertension (HTN) is a public health concern with significant possible long-term adverse outcomes. This review comprehensive guide for pediatricians, nephrologists, and trainees, focusing on the latest approaches HTN diagnoses in children highlighting importance of accurate blood pressure measurement techniques. We also explore current classification systems offer evidence-based management strategies tailored to pediatric patients. Lifestyle modifications are recommended first-line interventions, including dietary changes, physical activity, weight management. Pharmacological treatments severe cases or when lifestyle insufficient. The guidelines provide an overview commonly prescribed antihypertensive medications, potential complications associated untreated HTN, target organ damage increased cardiovascular risk adulthood, early recognition intervention. aims help healthcare professionals thoroughly understand improve diagnosis, treatment,

Language: Английский

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Alpha 1-antitrypsin mitigates salt-sensitive hypertension in juvenile mice by reducing diacylglycerol concentrations and protein kinase C activity in kidney membranes

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 20, 2025

Introduction Recombinant alpha-1 antitrypsin (AAT) therapy has been shown to have beneficial effects mitigate the progression of various diseases. Here, we hypothesized that administration pharmaceutical-grade human AAT (hAAT) is effective in mitigating hypertension induced by salt-loading juvenile mice reducing concentration diacylglycerols (DAGs) and activity protein kinase C (PKC) kidney. Methods Four-week old 129Sv were salt-loaded induce then administered hAAT or vehicle. Results Administration was found significantly reduce high blood pressure both active inactive cycles hypertensive mice. A lipidomic analysis showed decreased concentrations multiple kidney cortex membrane fractions from treated with compared PKC less received Western blotting immunohistochemistry density sodium-potassium-chloride co-transporter (NKCC2) reduced Conclusion Taken together, this study demonstrates a new protective effect normalizing after development saltinduced mechanism involving decrease NKCC2 expression, presumably due levels DAGs plasma subsequent activity.

Language: Английский

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