Plasma IL-6 levels and their association with brain health and dementia risk: A population-based cohort study DOI Creative Commons
Zhengyang Zhao, Jiashuo Zhang, Yulu Wu

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 120, P. 430 - 438

Published: June 17, 2024

Recent studies have associated immune abnormalities with dementia. IL-6 is a crucial cytokine in inflammatory responses, and recent evidence has linked elevated levels to changes brain structure cognitive decline. However, the connection between levels, cognition, volumes, dementia risk requires exploration large prospective cohorts.

Language: Английский

Transcriptional level of inflammation markers associates with short-term brain structural changes in first-episode schizophrenia DOI Creative Commons
Long‐Biao Cui,

Xian-Yang Wang,

Yu‐Fei Fu

et al.

BMC Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 10, 2023

Abstract Background Inflammation has been implicated in the pathology of schizophrenia and may cause neuronal cell death dendrite loss. Neuroimaging studies have highlighted longitudinal brain structural changes patients with schizophrenia, yet it is unclear whether this related to inflammation. We aim address question, by relating transcriptional profile inflammation markers early stage schizophrenia. Methods Thirty-eight first-episode 51 healthy controls were included. High-resolution T1-weighted magnetic resonance imaging (MRI) clinical assessments performed at baseline 2 ~ 6 months follow-up for all subjects. Changes structure analyzed using surface-based morphological analysis correlated expression immune cells-related gene sets interest reported previous reviews. Transcriptional data retrieved from Allen Human Brain Atlas. Furthermore, we examined peripheral association behavioral symptoms cognitive functioning patients. Results Patients exhibited accelerated cortical thickness decrease left frontal cortices, less or an increase superior parietal lobule right lateral occipital lobe, increased volume bilateral pallidum, compared controls. level monocyte across regions ( r = 0.54, p < 0.01), but not − 0.05, 0.76). In addition, change positively digital span-backward test scores Conclusions exhibit regional-specific prefrontal parietooccipital which their impairment. be important factor contributing thinning Our findings suggest that immunity-brain-behavior play a crucial role pathogenesis

Language: Английский

Citations

16
The association between schizophrenia and white blood cells count: a bidirectional two-sample Mendelian randomization study DOI Creative Commons

Zibo Gao,

Biao Li,

Xinru Guo

et al.

BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)

Published: April 19, 2023

Positive associations between the risk of schizophrenia and level white blood cells (WBC) count have been suggested by observational studies. However, causality this association is still unclear.We used a group bidirectional two-sample Mendelian randomization (MR) analyses to estimate causal relationship WBC traits (i.e., count, lymphocyte neutrophil basophil eosinophil monocyte count). The threshold FDR-adjusted P < 0.05 was considered as showing potential evidence effect. Instrument variables were included based on genome-wide significance (P 5 × 10- 8) linkage disequilibrium (LD) clumping (r2 0.01). In total, 81, 95, 85, 87, 76, 83 schizophrenia-related single nucleotide polymorphisms (SNPs) genetic instruments from Psychiatric Genomics Consortium for six traits, respectively. And in reverse MR analysis, 458, 206, 408, 468, 473, 390 variants extracted utilized instruments, which obtained recent large-scale Genome-Wide Association Study (GWAS).Genetically predicted positively associated with [odds ratio (OR) 1.017, 95% confidence interval (CI) 1.008-1.026; = 7.53 4], (OR 1.014, 95%CI 1.005-1.022; 0.002), 1.021, 1.011-1.031; 2.77 4), 1.018, 1.009-1.027; 4.60 1.012-1.030; 4.51 5), 1.013, 0.004). are not our results.Schizophrenia elevated levels higher

Language: Английский

Citations

15
Bidirectional two-sample Mendelian randomization study of differential white blood cell counts and schizophrenia DOI
Perry B.M. Leung, Zipeng Liu, Yuanxin Zhong

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 118, P. 22 - 30

Published: Feb. 13, 2024

Language: Английский

Citations

5
Association between psychiatric admissions in patients with schizophrenia and IL-6 plasma levels polygenic score DOI
Fernando Facal, Manuel Arrojo, Mario Páramo

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: 274(7), P. 1671 - 1679

Published: March 16, 2024

Language: Английский

Citations

5
Plasma IL-6 levels and their association with brain health and dementia risk: A population-based cohort study DOI Creative Commons
Zhengyang Zhao, Jiashuo Zhang, Yulu Wu

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 120, P. 430 - 438

Published: June 17, 2024

Recent studies have associated immune abnormalities with dementia. IL-6 is a crucial cytokine in inflammatory responses, and recent evidence has linked elevated levels to changes brain structure cognitive decline. However, the connection between levels, cognition, volumes, dementia risk requires exploration large prospective cohorts.

Language: Английский

Citations

5