Oxidative DNA base damage and base excision repair abnormalities in siblings of individuals with bipolar disorder DOI Creative Commons
Hidayet Ece Arat-Çelik,

Selda Yılmaz,

İzel Cemre Akşahin

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 9, 2023

Abstract Previous evidence suggests elevated levels of oxidative DNA damage, particularly 8-hydroxy-2'-deoxyguanosine (8-OH-dG), and abnormalities in the repair 8-OH-dG by base excision (BER) BD. However, genetic disposition these remains unknown. In this study, we aimed to investigate damage BER mechanisms individuals with BD their siblings, as compared healthy controls (HCs). 46 BD, 41 siblings 51 HCs were included study. Liquid chromatography-tandem mass spectrometry was employed evaluate urine, which then normalized based on urine creatinine levels. The real-time-polymerase chain reaction used measure expression 8-oxoguanine glycosylase 1 (OGG1), apurinic/apyrimidinic endonuclease (APE1), poly ADP-ribose polymerase (PARP1) , beta (POLβ) . found be both when HCs. OGG1 APE1 expressions downregulated, while POLβ upregulated patient sibling groups Age, smoking status, number depressive episodes had an impact group body index, past psychiatric history siblings. Both unaffected presented similar regarding BER, suggesting a link between / familial susceptibility Our findings suggest that targeting pathway could offer promising therapeutic strategies for reducing risk age-related diseases comorbidities predisposition

Language: Английский

Oxidative Stress-Induced Damage to RNA and DNA and Mortality in Individuals with Psychiatric Illness DOI

Anders Jorgensen,

Ivan Brandslund, Christina Ellervik

et al.

JAMA Psychiatry, Journal Year: 2024, Volume and Issue: 81(5), P. 516 - 516

Published: March 6, 2024

All-cause mortality and the risk for age-related medical disease is increased in individuals with psychiatric illness, but underlying biological mechanisms are not known. Oxidative stress on nucleic acids (DNA RNA; NA-OXS) a molecular driver of aging potential pathophysiological mechanism range disorders.

Language: Английский

Citations

7
Oxidation of DNA and RNA in young patients with newly diagnosed bipolar disorder and relatives DOI Creative Commons
Klara Coello,

Ilari Jaakko Olavi Mäkinen,

Hanne Lie Kjærstad

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 8, 2024

Excessive oxidative stress-generated nucleoside damage seems to play a key role in bipolar disorder (BD) and may present trait phenomenon associated with familial risk is one of the putative mechanisms explaining accelerated atherosclerosis premature cardiovascular diseases (CVD) younger patients BD. However, has not been studied young BD their unaffected relatives (UR). Therefore, we compared DNA RNA newly diagnosed BD, UR, healthy control individuals (HC). Systemic levels were by analyzing urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine 8-oxo-7,8-dihydroguanosine participants aged 15-25 years, including 133 57 83 HC. Compared HC, was 21.8% higher (B = 1.218, 95% CI 1.111-1.335, p <0.001) 22.5% UR 1.225, 1.090-1.377, <0.002), while 14.8% 1.148, 1.082-1.219, 14.0% 1.140, 1.055-1.230, < 0.001) models adjusted for sex age after correction multiple comparison. Levels did differ between UR. Our findings support being highlight importance early diagnosis treatment prevent illness progression development CVD.

Language: Английский

Citations

6
Deciphering the genetic underpinnings of neuroticism: A Mendelian randomization study of druggable gene targets DOI
Yanggang Hong, Yi Wang,

Wanyi Shu

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 370, P. 147 - 158

Published: Nov. 2, 2024

Language: Английский

Citations

6
Inflammatory and oxidative stress biomarkers in children and adolescents with bipolar disorder – A systematic review and meta-analysis DOI
Klaus Munkholm,

Ilari Jaakko Olavi Mäkinen,

Katrine Maigaard

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 163, P. 105766 - 105766

Published: June 15, 2024

Language: Английский

Citations

5
A comparative meta-analysis of peripheral 8-hydroxy-2′-deoxyguanosine (8-OHdG) or 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG) levels across mood episodes in bipolar disorder DOI

Hidayet Ece ARAT Çeli̇k,

Gamze Tuna, Deniz Ceylan

et al.

Psychoneuroendocrinology, Journal Year: 2023, Volume and Issue: 151, P. 106078 - 106078

Published: March 6, 2023

Language: Английский

Citations

12
Introducing the Role of Genotoxicity in Neurodegenerative Diseases and Neuropsychiatric Disorders DOI Open Access
Glen E. Kisby,

David M. Wilson,

Peter S. Spencer

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7221 - 7221

Published: June 29, 2024

Decades of research have identified genetic and environmental factors involved in age-related neurodegenerative diseases and, to a lesser extent, neuropsychiatric disorders. Genomic instability, i.e., the loss genome integrity, is common feature among both (mayo-trophic lateral sclerosis, Parkinson's disease, Alzheimer's disease) psychiatric (schizophrenia, autism, bipolar depression) instability associated with accumulation persistent DNA damage activation response (DDR) pathways, as well pathologic neuronal cell or senescence. Typically, DDR signaling ensures that genomic proteomic homeostasis are maintained dividing cells, including neural progenitors, post-mitotic neurons. However, dysregulation these protective responses, part due aging insults, contributes progressive development and/or In this Special Issue, we introduce highlight overlap between disorders, emerging clinical, genomic, molecular evidence for contributions aberrant repair. Our goal illuminate importance subject uncover possible treatment prevention strategies relevant devastating brain diseases.

Language: Английский

Citations

4
Immune and oxidative stress biomarkers in pediatric psychosis and psychosis-risk: Meta-analyses and systematic review DOI Creative Commons
Jerome H. Taylor,

Julieta Bermudez-Gomez,

Marina Zhou

et al.

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 117, P. 1 - 11

Published: Dec. 21, 2023

While genetic and cohort studies suggest immune reduction/oxidation (redox) alterations occur in psychosis, less is known about potential children adolescents.

Language: Английский

Citations

10
Mitochondrial respiratory activity and DNA damage in peripheral blood mononuclear cells in borderline personality disorder DOI Creative Commons
Alexander Behnke, Manuela Rappel, Laura Ramo‐Fernández

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract Alterations in the central and peripheral energy metabolism are increasingly recognized as key pathophysiological processes various psychiatric disorders. This case-control study investigates mitochondrial production oxidative DNA damage Borderline Personality Disorder (BPD). We compared respiration, density, blood mononuclear cells between women with acute BPD, remitted healthy controls ( n = 32, 15, 29), matched for age BMI. Acute BPD was characterized by reduced less efficient ATP to both (e.g., coupling efficiency: r x −0.36 −0.35, p adj ’s < .037). Decreased activity closely associated greater S −0.57, .001), although did not differ diagnostic groups. Our findings suggest promising sensitive biomarkers disorder severity clinical remission BPD.

Language: Английский

Citations

0
Effects of oxidative stress and GDNF on patients with bipolar disorder: a prospective study DOI Creative Commons

Qun Yang,

Chuanwei Li, Fei Jiang

et al.

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 19, 2025

Bipolar disorder (BD) is a common mental characterized by significant cognitive dysfunction, the mechanisms of which remain unclear. Oxidative stress and glial cell line-derived neurotrophic factor (GDNF) influence pathophysiology BD. Their specific roles, particularly concerning function during manic episodes, are The serum levels superoxide dismutase (SOD) malondialdehyde (MDA), GDNF were biochemically assayed in patients with bipolar mania before after treatment to explore their associations function. A total 75 acute episodes BD 70 healthy controls initially enrolled. During 4-week intervention period atypical antipsychotics mood stabilizers, 5 discontinued follow-up, resulting completers included final analysis. severity symptoms assessed using Young Mania Rating Scale (YMRS). Cognitive was Digit Cancellation, Stroop Color Word, Trail Making Tests. Serum SOD, MDA, measured biochemical assays. demonstrated higher SOD MDA lower compared controls, following improvements treatment. Pre-treatment YMRS scores assessments positively correlated levels, negatively levels. Treatment significantly improved function, although remained than controls. functions phase substantially advance understanding role oxidative Possible biomarkers for diagnosis prognosis assessment revealed. Further investigations into complex pathophysiological needed. Not applicable

Language: Английский

Citations

0
Investigation of malondialdehyde as a trait marker associated with familial risk in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives – a longitudinal cohort study. DOI
Klara Coello, Sharleny Stanislaus, Julie Lyng Forman

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0