Role of the gut microbiome in psychological symptoms associated with inflammatory bowel diseases

Seminars in Immunopathology, Journal Year: 2025, Volume and Issue: 47(1)

Published: Jan. 27, 2025

Abstract The brain-gut axis constitutes the basis for bidirectional communication between central nervous system and gastrointestinal tract driven by neural, hormonal, metabolic, immunological, microbial signals. Alterations in gut microbiome composition as observed inflammatory bowel diseases can modulate brain function emerging empirical evidence has indicated that interactions among microbiome-axis seem to play a significant role pathogenesis of both psychiatric disorders their comorbidity. Yet, immunological molecular mechanisms underlying co-occurrence psychological symptoms are still poorly understood. aim this narrative review is highlight contemporary findings supporting pivotal pathophysiology highly prevalent neuropsychiatric such fatigue, depression, anxiety. Finally, we focus on modulation potential treatment option comorbid immune-mediated especially diseases. High-quality clinical trials required clarify how through dietary interventions or probiotic, prebiotic synbiotic be used clinically improve mental health thus quality life patients with

Language: Английский

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Dysbiosis is associated with the behavioral phenotype observed in the triple-hit Wisket rat model of schizophrenia

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111276 - 111276

Published: Jan. 1, 2025

Language: Английский

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Genome-wide Mendelian randomization mapping the influence of plasma proteome on major depressive disorder

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Genome-wide pleiotropy analysis reveals shared architecture between renal traits and gastrointestinal tract diseases

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Background: Comorbidities between gastrointestinal tract (GIT) and renal diseases have been widely reported, but the shared genetic architecture of gut traits remains unclear. Objective: To investigate etiology causal relationships or involved in gut-renal axis. Methods: We explored global local correlations, pleiotropic effects at variants gene levels, associations pair-wise GIT diseases, as well potential target drugs by using latest large-scale genome-wide association study (GWAS) summary data five (BUN, eGFR, CKD, IgAN, KSD) four (PUD, GORD, IBD, IBS). Results: Renal were genetically correlated globally locally across eight 20 trait pairs (BUN-GORD, BUN-IBD, BUN-IBS, CKD-IBD, IgAN-IBD, KSD-PUD, KSD-GORD, KSD-IBS). Pleiotropic analysis identified 222 loci prioritized 169 genes for pairs, including 21 novel that not significant original GWASs, colocalized loci, 29 drug-targeting genes. Among rs3129861 HLA-DRA was potentially BUN-GORD (PP4 = 0.814). KIF5B is a eGFR-IBD CKD-IBD rs12572072 0.929) rs61844306 0.898), both which are eQTLs expressed cultured fibroblasts cells. CKD IBD also PVALEF with PP4 0.800 rs138610699. In addition, rs6873866 casual variant ERAP2 IgAN with PP4=0.800, rs6873866-C allele negatively associated expression multiple tissues. Furthermore, tissue cell-type specific enrichment found over-expressed kidney cortex, immune-related tissues cell types. Mendelian randomization revealed nominal observed on IBS, PUD GORD eGFR. Conclusion: These findings suggested highlighted analyses drug repurposing comorbidities

Language: Английский

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Global diversity in bipolar disorder: the role of cultural and social differences with a view to genomics

Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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