Does Gut Microbiome Composition Influence the Efficacy of Psychiatric Drugs? DOI Creative Commons

Nadia Suryawinata,

Sarkis K. Mazmanian

European Medical Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Altered gut microbiome profiles correlate with anxiety and depression in humans, work animal models has identified specific bacterial taxa and/or microbiome-derived metabolites that influence complex emotional behaviours. Intriguingly, many pharmaceuticals, including widely used oral treatments for depression, can be chemically modified by microbes the gastrointestinal tract, which may lead to drug inactivation. The authors highlight importance of integrating research across microbial culture systems, models, multi-omics analyses clinical cohorts gain mechanistic insights into whether composition determines efficacy, bioavailability, tolerability neuropsychiatric medications. This hypothesis, if validated, have profound implications personalised treatment plans microbiome-based biomarker development.

Language: Английский

Role of Inflammatory Mechanisms in Major Depressive Disorder: From Etiology to Potential Pharmacological Targets DOI Creative Commons
Bruna R. Kouba, Laura A. Borba, Pedro Borges de Souza

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 423 - 423

Published: Feb. 28, 2024

The involvement of central and peripheral inflammation in the pathogenesis prognosis major depressive disorder (MDD) has been demonstrated. increase pro-inflammatory cytokines (interleukin (IL)-1β, IL-6, IL-18, TNF-α) individuals with depression may elicit neuroinflammatory processes inflammation, mechanisms that, turn, can contribute to gut microbiota dysbiosis. Together, neuroinflammation dysbiosis induce alterations tryptophan metabolism, culminating decreased serotonin synthesis, impairments neuroplasticity-related mechanisms, glutamate-mediated excitotoxicity. This review aims highlight inflammatory (neuroinflammation, dysbiosis) involved pathophysiology MDD explore novel anti-inflammatory therapeutic approaches for this psychiatric disturbance. Several lines evidence have indicated that addition antidepressants, physical exercise, probiotics, nutraceuticals (agmatine, ascorbic acid, vitamin D) possess effects their antidepressant properties. Further studies are necessary benefits these alternative therapies MDD.

Language: Английский

Citations

65
Balancing the Mind: Toward a Complete Picture of the Interplay between Gut Microbiota, Inflammation and Major Depressive Disorder DOI Creative Commons

Nour Dabboussi,

Espérance Debs,

Marc Bouji

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 216, P. 111056 - 111056

Published: Aug. 24, 2024

The intricate interplay existing between gut microbiota and homeostasis extends to the realm of brain, where emerging research underscores significant impact on mood regulation overall neurological well-being vice-versa, with inflammation playing a pivotal role in mediating these complex interactions. This comprehensive review explores inflammation, alterations microbiota, their major depressive disorder (MDD). It provides cohesive framework for puzzle pieces this triad, emphasizing recent advancements understanding inflammatory states' contribution features. Two directions communication brain depression are discussed, serving as potential modulator. Therapeutic implications were discussed well, drawing insights from interventional studies effects probiotics bacterial composition symptoms. Ultimately, will attempt provide complete valuable future therapeutic interventions MDD.

Language: Английский

Citations

25
Gut Microbiota and Blood Metabolites Related to Fiber Intake and Type 2 Diabetes DOI Open Access
Zheng Wang, Brandilyn A. Peters, Bing Yu

et al.

Circulation Research, Journal Year: 2024, Volume and Issue: 134(7), P. 842 - 854

Published: March 28, 2024

BACKGROUND: Consistent evidence suggests diabetes-protective effects of dietary fiber intake. However, the underlying mechanisms, particularly role gut microbiota and host circulating metabolites, are not fully understood. We aimed to investigate metabolites associated with intake their relationships type 2 diabetes (T2D). METHODS: This study included up 11 394 participants from HCHS/SOL (Hispanic Community Health Study/Study Latinos). Diet was assessed two 24-hour recalls at baseline. examined associations microbiome measured by shotgun metagenomics (350 species/85 genera 1958 enzymes; n=2992 visit 2), serum metabolome untargeted metabolomics (624 metabolites; n=6198 baseline), between fiber-related bacteria (n=804 2). prospective microbial-associated (n=3579 baseline) incident T2D over 6 years. RESULTS: identified multiple bacterial genera, species, related enzymes Several (eg, Butyrivibrio , Faecalibacterium ) involved in degradation xylanase EC3.2.1.156) were positively intake, inversely prevalent T2D, favorably T2D-related metabolic traits. 159 47 which T2D. 18 these bacteria, including several microbial indolepropionate 3-phenylpropionate) risk Both favorable metabolites. The especially attenuated after further adjustment for CONCLUSIONS: Among United States Hispanics/Latinos, profiles These findings advance our understanding relationship diet

Language: Английский

Citations

23
Circulating metabolites modulated by diet are associated with depression DOI Creative Commons
Ashley van der Spek,

Isobel D. Stewart,

Brigitte Kühnel

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(9), P. 3874 - 3887

Published: July 26, 2023

Abstract Metabolome reflects the interplay of genome and exposome at molecular level thus can provide deep insights into pathogenesis a complex disease like major depression. To identify metabolites associated with depression we performed metabolome-wide association analysis in 13,596 participants from five European population-based cohorts characterized for depression, circulating using ultra high-performance liquid chromatography/tandem accurate mass spectrometry (UHPLC/MS/MS) based Metabolon platform. We tested 806 covering wide range biochemical processes including those involved lipid, amino-acid, energy, carbohydrate, xenobiotic vitamin metabolism their In conservative model adjusting life style factors cardiovascular antidepressant medication use identified 8 metabolites, 6 novel, significantly individuals increased levels retinol (vitamin A), 1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1) (lecithin) mannitol/sorbitol lower hippurate, 4-hydroxycoumarin, 2-aminooctanoate (alpha-aminocaprylic acid), 10-undecenoate (11:1n1) (undecylenic 1-linoleoyl-GPA (18:2) (lysophosphatidic acid; LPA 18:2) are observed. These either directly food derived or products host gut microbial food-derived products. Our Mendelian randomization suggests that low hippurate may be causal pathway leading towards findings highlight putative actionable targets prevention easily modifiable through diet interventions.

Language: Английский

Citations

29
“Inflamed” depression: A review of the interactions between depression and inflammation and current anti-inflammatory strategies for depression DOI Creative Commons

Yishu Yin,

Ting Ju,

Deyong Zeng

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 207, P. 107322 - 107322

Published: July 20, 2024

Depression is a common mental disorder, the effective treatment of which remains challenging issue worldwide. The clinical pathogenesis depression has been deeply explored, leading to formulation various pathogenic hypotheses. Among these, monoamine neurotransmitter hypothesis holds prominent position, yet it significant limitations as more than one-third patients do not respond conventional treatments targeting transmission disturbances. Over past few decades, growing body research highlighted link between inflammation and potential key factor in pathophysiology depression. In this review, we first summarize relationship depression, with focus on pathophysiological changes mediated by mechanisms linking well multiple anti-inflammatory strategies are also discussed, their efficacy safety assessed. This review broadens perspective specific aspects using for treating laying groundwork advancing precision medicine individuals suffering from "inflamed"

Language: Английский

Citations

15
Gut microbiome-derived indole-3-carboxaldehyde regulates stress vulnerability in chronic restraint stress by activating aryl hydrocarbon receptors DOI Creative Commons

C. CHEN,

Qiang Xiao,

Zhongyuan Wen

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 213, P. 107654 - 107654

Published: Feb. 12, 2025

Language: Английский

Citations

1
Multi-omics approaches in psychoneuroimmunology and health research: Conceptual considerations and methodological recommendations DOI Open Access
Summer Mengelkoch, Sophia Miryam Schüssler‐Fiorenza Rose, Ziv Lautman

et al.

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 114, P. 475 - 487

Published: Aug. 4, 2023

Language: Английский

Citations

18
Mendelian Randomization Study With Clinical Follow‐Up Links Metabolites to Risk and Severity of Pulmonary Arterial Hypertension DOI Creative Commons
Elham Alhathli, Thomas Julian,

Zain Girach

et al.

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: 13(6)

Published: March 8, 2024

Pulmonary arterial hypertension (PAH) exhibits phenotypic heterogeneity and variable response to therapy. The metabolome has been implicated in the pathogenesis of PAH, but previous works have lacked power implicate specific metabolites. Mendelian randomization (MR) is a method for causal inference between exposures outcomes.

Language: Английский

Citations

7
Microbiota–gut–brain axis: the mediator of exercise and brain health DOI Creative Commons

Piao Kang,

Alan Wang

Deleted Journal, Journal Year: 2024, Volume and Issue: 4

Published: Jan. 1, 2024

Abstract The brain controls the nerve system, allowing complex emotional and cognitive activities. microbiota–gut–brain axis is a bidirectional neural, hormonal, immune signaling pathway that could link gastrointestinal tract to brain. Over past few decades, gut microbiota has been demonstrated be an essential component of plays crucial role in regulating most functions various body organs. effects on occur through production neurotransmitters, hormones, metabolites, regulation host-produced or synthesis metabolites by themselves. This affects host's behavior, mood, attention state, brain's food reward system. Meanwhile, there intimate association between exercise. Exercise can change numerically qualitatively, which may partially responsible for widespread benefits regular physical activity human health. Functional magnetic resonance imaging (fMRI) non-invasive method show areas enabling delineation specific regions involved neurocognitive disorders. Through combining exercise tasks fMRI techniques, researchers observe higher functions. However, exercise's health via have little studied. article reviews highlights connections these three interactions, will help us further understand positive provide new strategies approaches prevention treatment diseases.

Language: Английский

Citations

7
Dietary Acculturation Is Associated With Altered Gut Microbiome, Circulating Metabolites, and Cardiovascular Disease Risk in US Hispanics and Latinos: Results From HCHS/SOL DOI
Yi Wang, Guo‐Chong Chen, Zheng Wang

et al.

Circulation, Journal Year: 2024, Volume and Issue: 150(3), P. 215 - 229

Published: June 19, 2024

Dietary acculturation, or adoption of dominant culture diet by migrant groups, influences human health. We aimed to examine dietary acculturation and its relationships with cardiovascular disease (CVD), gut microbiota, blood metabolites among US Hispanic Latino adults.

Language: Английский

Citations

7