Positive and negative affect, related mental health traits, and cognitive performance: shared genetic architecture and potential causality DOI Creative Commons
Chloe Slaney, Naoise Mac Giollabhui, Peter J. van der Most

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 2, 2024

Altered affect and cognitive dysfunction are transdiagnostic, burdensome, pervasive features of many psychiatric conditions which remain poorly understood have few efficacious treatments. Research on the genetic architecture these phenotypes causal relationships between them may provide insight into their aetiology comorbidity. Using data from Lifelines Cohort Study, we conducted genome-wide association studies (GWAS) positive negative four domains (working memory, reaction time, visual learning executive function). publicly available large GWAS related - albeit distinct-phenotypes (depression, anxiety, wellbeing, general ability [GCA]) correlation Mendelian randomization (MR) analyses to examine overlap relationships. We identified one hit (

Language: Английский

Beyond Discrete Classifications: A Computational Approach to the Continuum of Cognition and Behavior in Children DOI Creative Commons
Anthony Gagnon, Virginie Gillet,

Anne-Sandrine Desautels

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Psychiatry is undergoing a shift toward precision medicine, demanding personalized approaches that capture the complexity of cognition and behavior. Here, we introduce novel referential four robust, replicable, generalizable cognitive behavioral profiles. These were derived from most prominent pediatric cohort (n=10,843) validated in two independent cohorts (n=195 n=271). We demonstrate profiles’ longitudinal stability consistency with clinical diagnoses while exposing critical discrepancies across parent-reported, youth-reported, expert-derived diagnoses. Beyond validation, showcase real-world utility our approach by linking profiles to environmental factors, revealing associations between parental influences youths’ Our fuzzy profiling framework moves beyond discrete classification, offering powerful tool refine psychiatric evaluation intervention. provide an open-source framework, enabling researchers clinicians fast-track implementation foster data-driven, domain-based diagnosis. findings advocate for broadening scope assessment.

Language: Английский

Citations

0
Positive and negative affect, related mental health traits, and cognitive performance: shared genetic architecture and potential causality DOI Creative Commons
Chloe Slaney, Naoise Mac Giollabhui, Peter J. van der Most

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 2, 2024

Altered affect and cognitive dysfunction are transdiagnostic, burdensome, pervasive features of many psychiatric conditions which remain poorly understood have few efficacious treatments. Research on the genetic architecture these phenotypes causal relationships between them may provide insight into their aetiology comorbidity. Using data from Lifelines Cohort Study, we conducted genome-wide association studies (GWAS) positive negative four domains (working memory, reaction time, visual learning executive function). publicly available large GWAS related - albeit distinct-phenotypes (depression, anxiety, wellbeing, general ability [GCA]) correlation Mendelian randomization (MR) analyses to examine overlap relationships. We identified one hit (

Language: Английский

Citations

1