Contrast-enhanced mammography for surveillance in women with a personal history of breast cancer

Breast Cancer Research and Treatment, Journal Year: 2024, Volume and Issue: 208(2), P. 293 - 305

Published: July 4, 2024

Women with a personal history of breast cancer have an increased risk subsequent malignancy and may benefit from more sensitive surveillance than conventional mammography (MG). We previously reported outcomes for first episode using contrast-enhanced (CEM), demonstrating higher sensitivity comparable specificity to MG. now report CEM performance surveillance.

Language: Английский

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Pre‐Treatment Breast MRI: Clinical Indications, Outcomes, and Future Directions

Journal of Magnetic Resonance Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

ABSTRACT Breast MRI is the most sensitive modality for assessing extent of disease in patients with newly‐diagnosed breast cancer because it identifies clinically‐ and mammographically‐occult cancers. Though highly sensitive, has lower specificity that may result false positive findings potential overestimation if additional are not biopsied prior to surgery. It had been anticipated superior detection rate pre‐treatment would translate improved immediate (surgical re‐excision) long‐term patient outcomes such as recurrence survival rates, but studies have necessarily supported this assumption. In review, current recommendations utilization local staging will be presented, an emphasis on specific clinical scenarios selection its impact short‐ outcomes. We also present new evidence support de‐escalation treatment discuss emerging advanced techniques improve diagnostic performance.

Language: Английский

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Enhancing Early-Stage Breast Cancer Survivorship: Evidence-Based Strategies, Surveillance Testing, and Imaging Guidelines

American Society of Clinical Oncology Educational Book, Journal Year: 2024, Volume and Issue: 44(3)

Published: May 30, 2024

Addressing the challenges of survivorship necessitates a comprehensive, patient-centered approach, focusing on mitigating risk through lifestyle modification, identifying distant recurrence, and optimization breast imaging. This article will discuss current emerging clinical strategies for period, advocating multidisciplinary comprehensive approach. In this manner, early-stage cancer survivors are empowered to navigate their journey with enhanced knowledge, facilitating transition life beyond cancer.

Language: Английский

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Patterns of Recurrence and Survival Outcomes of HER2-Low Expression in Early-Stage Breast Cancer

Clinical Breast Cancer, Journal Year: 2024, Volume and Issue: 25(3), P. 242 - 250.e6

Published: Nov. 27, 2024

Language: Английский

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Efficacy of radiation therapy in Japanese patients with positive margins after breast-conserving surgery

Japanese Journal of Clinical Oncology, Journal Year: 2024, Volume and Issue: 54(5), P. 556 - 561

Published: Jan. 20, 2024

Abstract Background Additional surgical resection is recommended after breast-conserving surgery if the margin pathologically positive. However, in clinical practice, radiation therapy sometimes used instead for several reasons. Irradiation may be appropriate some patients, but real-world data still insufficient to establish it as standard treatment. We retrospectively investigated status of local control patients who received irradiation positive margins. Methods 85 with margins curative partial mastectomy were treated additional excision during period 2006–2013. The whole-breast (43.2–50 Gy) using photon beams and tumour-bed boost (8.1–16 electron beams. Intrabreast tumour recurrence was defined secondary cancer within ipsilateral conserved breast. Surgical cell exposure confirmed on margin. Results Seven (8.2%) developed intrabreast a mean observation 119 months. As components margin, 76 cases an intraductal component, which seven (9.2%) recurrence. Meanwhile, all nine invasive component free from Two seemed develop new lesions rather than recurrence, considering location. cumulative incidence over 10 years 6.1%. Limited true 4.9%. Conclusion Our supports alternative intervention offers basis further research.

Language: Английский

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Locoregional recurrence after neoadjuvant versus adjuvant chemotherapy based on tumor subtypes in patients with early-stage breast cancer: A multi-institutional retrospective cohort study

The Breast, Journal Year: 2024, Volume and Issue: 78, P. 103828 - 103828

Published: Oct. 30, 2024

Neoadjuvant chemotherapy (NACT) for early-stage breast cancer is associated with an increased risk of locoregional recurrence (LRR). We investigated whether the LRR after NACT varies across tumor subtypes.

Language: Английский

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Breast cancer recurrence in relation to mode of detection: Implications on personalized surveillance

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Purpose The effectiveness of current follow-up guidelines after breast cancer treatment is uncertain. Tailored surveillance based on patient age and tumor characteristics may be more adequate. This study aimed to analyze the frequency risk factors for detecting ipsilateral locoregional recurrences (LR) second primary cancers (SP) outside scheduled in patients with recurrent cancer. Methods Patients surgically treated early-stage from Malmö Diet Cancer Study (MDCS), 1991–2014 (n = 1080), Västernorrland region, 2009–2018 1648), were included. Clinical pathological information was retrieved medical records. mode recurrence detection defined as within (planned) or (symptomatic) surveillance. Results median 6.5 years. Overall, 461 experienced a recurrence. most common initial event distant metastasis (47%), followed by (22%) (18%). Fifty-six percent LR 28% SP identified Logistic regression analysis revealed that younger (under 50 years) (OR 2.57, 95% CI 1.04–6.88), lymph node-positive 2.20, 1.03–4.87) HER2 positive subtype 5.24, 1.40–25.90) correlated higher odds planned Conclusion Most events detected surveillance, particularly recurrences. Risk-based which takes into account characteristics, might suitable specific subsets.

Language: Английский

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Risk Factors and Recurrence Patterns of Breast Cancer Recurrence after Postoperative Radiotherapy

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(01), P. 781 - 789

Published: Jan. 1, 2024

Language: Английский

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Nomograms to Predict Individual Potential Benefit from Targeted Therapy for patients with lymph node positive Luminal B (HER2-) breast cancer

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 17, 2024

PurposeTo construct nomograms combining clinicopathological characteristics, bone metastases (BM), viscera (VM) and cancer-related deaths (CRD) to predict the higher-risk patients with lymph node positive (N+) Luminal B (HER2-) breast cancer (BC).MethodKaplan-Meier survival analysis, Venn diagram, Bar charts were used describe data for subsequent metastasis CRD. Thirty-six characteristics extracted in univariate multivariate Cox regression analyses develop nomogram potential risk of BM, VM CRD among N+ BC. The calibration plots, concordance index receiver operating (ROC) analysis applied determine accuracy.ResultThe median age 8139 was 51 years, a follow-up 124 months (4–216 months). There no statistical difference between metachronous primary bilateral BC synchronous number-peak period BM third year, 4th year 6th^{year (range second–6th 4th–6th third–8th respectively). showed outstanding performance discriminative ability (C-index 0.69, 0.68 0.71, curves ROC demonstrated considerable clinical usefulness combined nomogram. Three examples results differences optimal who had similar pathological stage.ConclusionThe developed model consisting time-event-dependent could reliable predicting probability}

Language: Английский

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Comparison of long-term oncologic outcomes of central lumpectomy and conventional breast-conserving surgery for invasive breast cancer: propensity score matching analysis

Breast Cancer Research and Treatment, Journal Year: 2024, Volume and Issue: 205(3), P. 465 - 474

Published: March 25, 2024

Abstract Purpose Central lumpectomy (CL) is a breast-conserving surgical (BCS) technique that involves excision of the nipple-areolar complex with breast tumor in centrally located cancers. We aimed to investigate long-term clinical outcomes CL comparison conventional BCS (cBCS). Methods Patient records who underwent clear resection margins for invasive cancer between 2004 and 2018 were retrospectively reviewed. Of total 6,533 patients, 106 (1.6%) CL. Median follow-up duration was 73.4 months. 1:3 propensity score matching (PSM) inverse probability treatment weighting (IPTW) used minimize selection bias. Results The group showed significantly higher ipsilateral recurrence (IBTR) rate than cBCS (10-year IBTR rate: 5.8% vs. 3.1%, p = 0.004), even after adjusting other variables (hazard ratio (HR), 2.65; 95% confidence interval (CI), 1.07–6.60, 0.048). However, there no significant differences observed regional recurrence, distant metastasis, or overall survival rates two groups. Both PSM IPTW analyses (PSM HR, 3.27; CI, 0.94–11.36; 0.048 4.66; 95%CI, 1.85–11.77; < 0.001). Lastly, when analyzing 2,213 patients whose tumors within 3 cm nipple, before PSM. Conclusion associated compared cBCS, while comparable. For tumors, may be considered preferring preservation. risk should informed careful surveillance necessary during early post-operative periods.

Language: Английский

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