International Journal of Nanomedicine,
Journal Year:
2021,
Volume and Issue:
Volume 16, P. 7891 - 7941
Published: Dec. 1, 2021
Abstract:
Despite
recent
advances
in
the
diagnosis
and
treatment
of
breast
cancer
(BC),
it
remains
a
global
health
issue
affecting
millions
women
annually.
Poor
prognosis
BC
patients
is
often
linked
to
drug
resistance
as
well
lack
effective
therapeutic
options
for
metastatic
triple-negative
BC.
In
response
these
unmet
needs,
extensive
research
efforts
have
been
devoted
exploring
anti-BC
potentials
natural
products
owing
their
multi-target
mechanisms
action
good
safety
profiles.
Various
medicinal
plant
extracts/essential
oils
bioactive
compounds
demonstrated
anti-cancer
activities
preclinical
models.
promising
results,
however,
clinical
translation
has
hindered
by
poor
stability,
aqueous
solubility
bioavailability.
There
attempts
overcome
limitations,
particularly
via
use
nano-based
delivery
systems
(NDDSs).
This
review
highlights
tumour
targeting
NDDSs,
advantages
disadvantages
major
classes
NDDSs
current
status
treatment.
Besides,
also
discusses
proposed
nanoformulations
nine
plants'
compounds;
selected
screening
various
scientific
databases,
including
PubMed,
Scopus
Google
Scholar,
based
on
following
keywords:
"Natural
Product
AND
Nanoparticle
Breast
Cancer".
Overall,
exhibit
improved
efficacy
against
models,
with
some
demonstrating
biocompatibility
normal
cell
lines
mouse
Further
studies
are,
warranted
ascertain
humans.
Keywords:
cancer,
delivery,
molecular
mechanisms,
nanoparticles,
products,
phytomedicine
Frontiers in Pharmacology,
Journal Year:
2019,
Volume and Issue:
9
Published: March 19, 2019
-Synuclein
(-syn)
is
a
presynaptic
protein
that
regulates
the
release
of
neurotransmitters
from
synaptic
vesicles
in
brain.
-Syn
aggregates,
including
Lewy
bodies,
are
features
both
sporadic
and
familial
forms
Parkinson's
disease
(PD).
These
aggregates
undergo
several
key
stages
fibrillation,
oligomerization,
aggregation.
Therapeutic
benefits
drugs
decline
with
progression
offer
only
symptomatic
treatment.
This
requires
novel
therapeutic
strategies,
which
can
either
prevent
or
modify
process.
The
link
between
-syn
etiopathogenesis
PD
well
established
literature.
Studies
indicate
an
important
target
inhibition
aggregation,
fibrillation
modification
strategy.
However,
recent
studies
have
shown
plant
extracts
phytochemicals
neuroprotective
effects
on
oligomerization
by
targeting
different
its
formation.
Although
many
reviews
antioxidant-mediated,
effect
symptoms
been
highlighted,
antioxidant
mechanisms
show
limited
success
for
translation
to
clinical
studies.
identification
specific
α-syn
aggregation
will
provide
selective
molecules
develop
new
PD.
present
review
provides
overview
summarizes
observed
underlying
mechanisms.
Furthermore,
we
synopsis
current
experimental
models
techniques
used
evaluate
phytochemicals.
Plant
were
found
inhibit
fibril
formation
oligomers.
also
appear
direct
oligomer
into
unstructured
form
promote
nontoxic
pathways
suggested
be
valuable
drug
candidates
related
synucleinopathy.
Current
evidence
vitro
require
confirmation
vivo
Further
needed
ascertain
their
potential
safety
preclinical
pharmaceutical/nutritional
development
these
dietary
inclusion
International Journal of Cancer,
Journal Year:
2018,
Volume and Issue:
145(7), P. 1731 - 1744
Published: Nov. 2, 2018
Discovery
and
development
of
new
potentially
selective
anticancer
agents
are
necessary
to
prevent
a
global
cancer
health
crisis.
Currently,
alternative
medicinal
derived
from
plants
have
been
extensively
investigated
develop
drugs
with
fewer
adverse
effects.
Among
them,
steroidal
alkaloids
conventional
secondary
metabolites
that
comprise
an
important
class
natural
products
found
in
plants,
marine
organisms
invertebrates,
constitute
judicious
choice
as
potential
anti‐cancer
leads.
Traditional
medicine
modern
science
shown
representatives
this
compound
group
possess
antimicrobial,
analgesic,
anti‐inflammatory
Therefore,
systematic
recapitulated
information
about
the
bioactivity
these
compounds,
special
emphasis
on
molecular
or
cellular
mechanisms,
is
high
interest.
In
review,
we
methodically
discuss
vitro
vivo
activity
their
synthetic
semi‐synthetic
derivatives.
This
review
focuses
cumulative
comprehensive
which
will
help
researchers
understand
pathways
involving
steroid
generate
safe
lead
improved
therapeutic
applications
for
prevention
therapy.
studies
provide
evidence
promising
various
cell
lines,
but
advanced
pharmacokinetic
clinical
experiments
required
more
treatment.
Food & Function,
Journal Year:
2020,
Volume and Issue:
12(2), P. 519 - 542
Published: Dec. 10, 2020
Due
to
recent
lifestyle
shifts
and
health
discernments
among
consumers,
synthetic
drugs
are
facing
the
challenge
of
controlling
disease
development
progression.
Various
medicinal
plants
their
constituents
recognized
for
imminent
role
in
management
via
modulation
biological
activities.
At
present,
research
scholars
have
diverted
attention
on
natural
bioactive
entities
with
health-boosting
perception
combat
lifestyle-related
disarrays.
In
particular,
Zingiber
officinale
is
a
herb
that
has
been
commonly
used
food
pharmaceutical
products.
Its
detailed
chemical
composition
high
value-added
active
components
extensively
studied.
this
review,
we
summarized
pharmacological
potential
well-endowed
chemo
preventive
agent.
It
was
revealed
its
functionalities
attributed
several
inherent
constituents,
including
6-gingerol,
8-gingerol,
10-gingerol,
6-shogaol,
6-hydroshogaol,
oleoresin,
which
were
established
through
many
studies
(in
vitro,
vivo,
cell
lines).
also
focused
therapeutic
effects
ginger
effective
antioxidant
properties.
Their
consumption
may
reduce
or
delay
progression
related
diseases,
such
as
cancer,
diabetes,
obesity,
genetic
metabolic
The
updated
data
could
elucidate
relationship
extraction
processes
manifestations.
We
collated
current
knowledge
(including
latest
clinical
data)
about
compounds
bioactivities
ginger.
mechanisms,
can
lay
foundation
medical
applications
discussed.
International Journal of Nanomedicine,
Journal Year:
2021,
Volume and Issue:
Volume 16, P. 7891 - 7941
Published: Dec. 1, 2021
Abstract:
Despite
recent
advances
in
the
diagnosis
and
treatment
of
breast
cancer
(BC),
it
remains
a
global
health
issue
affecting
millions
women
annually.
Poor
prognosis
BC
patients
is
often
linked
to
drug
resistance
as
well
lack
effective
therapeutic
options
for
metastatic
triple-negative
BC.
In
response
these
unmet
needs,
extensive
research
efforts
have
been
devoted
exploring
anti-BC
potentials
natural
products
owing
their
multi-target
mechanisms
action
good
safety
profiles.
Various
medicinal
plant
extracts/essential
oils
bioactive
compounds
demonstrated
anti-cancer
activities
preclinical
models.
promising
results,
however,
clinical
translation
has
hindered
by
poor
stability,
aqueous
solubility
bioavailability.
There
attempts
overcome
limitations,
particularly
via
use
nano-based
delivery
systems
(NDDSs).
This
review
highlights
tumour
targeting
NDDSs,
advantages
disadvantages
major
classes
NDDSs
current
status
treatment.
Besides,
also
discusses
proposed
nanoformulations
nine
plants'
compounds;
selected
screening
various
scientific
databases,
including
PubMed,
Scopus
Google
Scholar,
based
on
following
keywords:
"Natural
Product
AND
Nanoparticle
Breast
Cancer".
Overall,
exhibit
improved
efficacy
against
models,
with
some
demonstrating
biocompatibility
normal
cell
lines
mouse
Further
studies
are,
warranted
ascertain
humans.
Keywords:
cancer,
delivery,
molecular
mechanisms,
nanoparticles,
products,
phytomedicine
