The transcription factor STAT3 and aging: an intermediate medium

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 7, 2025

Language: Английский

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Role of FHOD1 in tumor cells and tumor immune microenvironment

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 29, 2025

FHOD 1 (Formin homology 2 domain containing protein 1) is a member of Diaphanous-related formins (DRFs) which contains GTP-binding (GBD), formin (FH) and FH domains, coiled-coil, diaphanous-like autoregulatory domain. Studies have shown that FHOD1 can not only regulate intracellular signals in tumor cells but also various components the microenvironment (TME), such as T cells, B cancer-associated fibroblasts (CAFs), some cytokines. Aberrant expression dysfunction play key role immunosuppression. Specifically, impair function chemokine receptors are supposed to direct immune localize site accurately. As result this impairment, cannot migrate efficiently into TME, thereby impairing their ability attack cells. In addition, activated signaling pathways within abnormally, resulting inability recognize destroy effectively. Therefore, ultimately leads state immunosuppression providing favorable conditions for growth spread Altogether review provides an in-depth understanding

Language: Английский

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Deucravacitinib Treatment for Psoriasis Complicated by Myelodysplastic Syndrome Without Exacerbation of the Underlying Hematologic Disorder: A Case Report

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Language: Английский

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Molecular and cellular pathways of aging in hematopoiesis

FEBS Letters, Journal Year: 2024, Volume and Issue: 598(22), P. 2751 - 2754

Published: Nov. 1, 2024

Language: Английский

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